[1]张露,李霞.TGF-β在角膜损伤修复中的时间和空间分布[J].眼科新进展,2017,37(2):184-188.[doi:10.13389/j.cnki.rao.2017.0048]
 ZHANG Lu,LI Xia.Temporal and spatial distribution of TGF-β in corneal wound healing[J].Recent Advances in Ophthalmology,2017,37(2):184-188.[doi:10.13389/j.cnki.rao.2017.0048]
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TGF-β在角膜损伤修复中的时间和空间分布/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
37卷
期数:
2017年2期
页码:
184-188
栏目:
文献综述
出版日期:
2017-02-05

文章信息/Info

Title:
Temporal and spatial distribution of TGF-β in corneal wound healing
作者:
张露李霞
530021 广西壮族自治区南宁市,广西医科大学第一附属医院眼科
Author(s):
ZHANG LuLI Xia
Department of Ophthalmology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Autonomous Region,China
关键词:
角膜损伤修复转化生长因子-β时空分布
Keywords:
corneal wound healingtransforming growth factor-βtemporal and spatial distribution
分类号:
R772.2
DOI:
10.13389/j.cnki.rao.2017.0048
文献标志码:
A
摘要:
角膜损伤后的纤维化修复是角膜瘢痕形成的主要原因。转化生长因子-β(transforming growth factor-beta,TGF-β)在角膜的稳态平衡中起着至关重要的作用,是角膜损伤修复的重要参与者。同时,角膜上皮基底膜是角膜创伤修复过程中角膜上皮与基质相互作用的重要屏障。角膜损伤修复的不同阶段,各亚型TGF-β在角膜各种细胞及各个不同部位存在着分布差异,角膜上皮基底膜是否完整是影响该过程的重要因素。TGF-β不同亚型在时间和空间上的分布差异及变化与角膜的创伤修复过程中细胞的迁移、增殖、表型变化及细胞外基质沉着都紧密相关,是瘢痕愈合及无瘢痕愈合的细胞分子生物学基础。本文就TGF-β的生物学功能及其亚型在角膜损伤修复中的时间和空间分布情况作一综述。
Abstract:
Fibrosis is the major cause of corneal scarring.Transforming growth factor-beta (TGF-β) plays a key role in corneal homeostasis and repair.Corneal epithelial basement membrane is thought to be the important barrier of corneal epithelium-stroma interaction.In different stages of corneal wound healing,the isoforms of TGF-β have different temporal and spatial expression.The integrity of basement membrane is a critical factor of these procedures.The temporal and spatial distributions of TGF-β isoforms play the crucial roles in cell migration,proliferation,phenotype changes and deposition of extracellular matrix in corneal wound healing.It is the mechanism of corneal scarring and scar-free healing.This article reviews recent articles to elucidate the biological functions of TGF-β and the temporal and spatial distribution of its isoforms in corneal wound healing.

参考文献/References:

[1] 李金瑛,肖诗艺,傅培.TGF-β2反义寡核苷酸对兔角膜基质创伤修复的影响[J].国际眼科杂志,2006,6(2):1016-1018.
LI JY,XIAO SY,FU P.Influence of the fibroblast activity by TGF-β2 antisense oligonucleotide in corneal stroma injury of rabbit[J].Int J Ophthalmol,2006,6(2):1016-1018.
[2] 李婧,沈政伟.角膜TGF-β与屈光手术损伤愈合的关系[J].国际眼科杂志,2011,11(11):1935-1937.
LI J,SHEN ZW.Relationship of TGF-β and corneal wound healing for excimer laser refractive surgery[J].Int J Ophthalmol,2011,11(11):1935-1937.
[3] 韩治华,杨淑,郭卫民,刘喜燕.TGF-β介导的Smad信号通路增生型糖尿病视网膜病变中的作用和意义[J].眼科新进展,2016,36(10):957-960.
HAN ZH,YANG S,GUO WM,LIU XY.Role and significance of TGF-β mediated Smad signaling pathways in proliferative diabetic retinopathy[J].Rec Adv Ophthalmol,2016,36(10):957-960.
[4] 靳荷,李霞.TGF-β在角膜瘢痕形成及无瘢痕愈合中的作用[J].眼科新进展,2014,34(11):1087-1090.
JIN H,LI X.Role of TGF-β in corneal stromal scarring and scar-free wound healing[J].Rec Adv Ophthalmol,2014,34(11):1087-1090.
[5] ROBERTS AB.Molecular and cell biology of TGF-beta[J].Miner Electrolyte Metab,1998,24(2-3):111-119.
[6] CHIN D,BOYLE GM,PARSONS PG,COMAN WB.What is transforming growth factor-beta (TGF-β) [J]?Br J Plast Surg,2004,57(3):215-221.
[7] CORDEIRO MF.Beyond mitomycin:TGF-beta and wound healing[J].Prog Retin Eye Res,2002,21(1):75-89.
[8] WILSON SE,CHEN L,MOHAN RR,LIANG Q,LIU J.Expression of HGF,KGF,EGF and receptor messenger RNAs following corneal epithelial wounding[J].Exp Eye Res,1999,68(4):377-397.
[9] IMANISHI J,KAMIYAMA K,IGUCHI I,MASAKAZU K,CHIE S,SHIGERU K.Growth factors:importance in wound healing and maintenance of transparency of the cornea[J].Prog Retin Eye Res,2000,19 (1):113-129.
[10] BLOBE GC,SCHIEMANN WP,LODISH HF.Role of transforming growth factor beta in human disease[J].N Engl J Med,2000,342(18):1350-1358.
[11] SHARMA G,HE J,BAZAN HE.P38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing:evidence of cross-talk activation between MAP kinase cascades[J].J Biol Chem,2003,278(24):21989-21997.
[12] SAIKA S.TGF-beta pathobiology in the eye[J].Lab Invest,2006,86(2):106-115.
[13] SHARMA A,THAKKAR M,VIJ N,SINHA S,MOHAN RR.PDGF-driven proliferation,migration,and IL8 chemokine secretion in human corneal fibroblasts involve JAK2-STAT3 signaling pathway[J].Mol Vis,2008,14:1020-1027.
[14] LAIHO M,SAKSELA O,KESKIOJA J.Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor.Pericellular deposition and sensitivity to exogenous urokinase[J].J Biol Chem,1987,262(36):17467-17474.
[15] STREULI CH,SCHMIDHAUSER C,KOBRIN M,BISSELL MJ,DERYNCK R.Extracellular matrix regulates expression of the TGF-beta1 gene[J].J Cell Biol,1993,120(1):253-260.
[16] WILSON SE.Corneal myofibroblast biology and pathobiology:Generation,persistence,and transparency[J].Exp Eye Res,2012,99(1):78-88.
[17] CARRINGTON LM,ALBON J,ANDERSON I,KAMMA C,BOULTON M.Differential regulation of key stages in early corneal wound healing by TGF-beta isoforms and their inhibitors[J].Invest Ophthalmol Vis Sci,2006,47(5):1886-1894.
[18] TUOMINEN IS,TERVO TM,TEPPO AM,VALLE TU,GRONHAGEN-RISKA C,VESALUOMA MH.Human tear fluid PDGF-BB,TNF-alpha and TGF-beta1 vs corneal haze and regeneration of corneal epithelium and subbasal nerve plexus after PRK[J].Exp Eye Res,2001,72(6):631-641.
[19] SONG QH,KLEPEIS VE,NUGENT MA,TRINKAUS-RANDALL V.TGF-beta1 regulates TGF-beta1 and FGF-2 mRNA expression during fibroblast wound healing[J].Mol Pathol,2002,55(3):164-176.
[20] JAMIN-MANIFICAT H,ROVERE MR,GALIACY SD,MALECAZE F,HULMES DJ,MOALI C,et al.Development of ex vivo organ culture models to mimic human corneal scarring[J].Mol Vis,2012,18:2896-2908.
[21] STRISSEL KJ,RINEHART WB,FINI ME.A corneal epithelial inhibitor of stromal cell collagenase synthesis identified as TGF-beta 2[J].Invest Ophthalmol Vis Sci,1995,36(1):151-162.
[22] FINI ME,STRAMER BM.How the cornea heals:cornea-specific repair mechanisms affecting surgical outcomes[J].Cornea,2005,24(8 Suppl):S2-S11.
[23] JOKO T,SHIRAISHI A,AKUNE Y,TOKUMARU S,KOBAYASHI T,MIYATA K,et al.Involvement of P38MAPK in human corneal endothelial cell migration induced by TGF-beta2[J].Exp Eye Res,2013,108(1):23-32.
[24] ANSCHER MS.Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapy[J].Oncologist,2010,15(4):350-359.
[25] KARAMICHOS D,HUTCHEON AEK,ZIESKE JD.Transforming growth factor-β3 regulates assembly of a non-fibrotic matrix in a 3D corneal model[J].J Tissue Eng Regen Med,2011,5(8):e228-e238.
[26] KARAMICHOS D,HUTCHEON AEK,ZIESKE JD.Reversal of fibrosis by TGF-beta3 in a 3D in vitro model[J].Exp Eye Res,2014,124(1):31-36.
[27] HUH MI,CHANG Y,JUNG JC.Temporal and spatial distribution of TGF-beta isoforms and signaling intermediates in corneal regenerative wound repair[J].Histol Histopathol,2009,24(11):1405-1416.
[28] HUH MI,KIM YH,PARK JH,BAE EW,KIM MH,CHANG YM,et al.Distribution of TGF-beta isoforms and signaling intermediates in corneal fibrotic wound repair[J].J Cell Biochem,2009,108(2):476-488.
[29] 盖小雄,周启璠,陈国良.转化生长因子-β抑制剂研究进展[J].药学学报,2015,50(4):413-418.
GAI XX,ZHOU QF,CHEN GL.Advances of transforming growth factor-β inhibitors[J].Acta Pharmaceutica Sinica,2015,50 (4):413-418.
[30] TANDON A,TOVEY JCK,SHARMA A,GUPTA R,MOHAN RR.Role of transforming growth factor beta in corneal function,biology and pathology[J].Curr Mol Med,2010,10(6):565-578.
[31] PASQUALE LR,DORMANPEASE ME,LUTTY GA,QUIGLEY HA,JAMPEL HD.Immunolocalization of TGF-beta1,TGF-beta2,and TGF-beta3 in the anterior segment of the human eye[J].Invest Ophthalmol Visl Sci,1993,34(1):23-30.
[32] CHEN J,CHEN Y,HAN SN,ZOU YP,ZOU XL.Transforming growth factor-β1 level in tears and corneal haze formation following flap-on or flap-off Epi-LASIK[J].Nan Fang Yi Ke Da Xue Xue Bao,2013,33(5):631-634.
[33] TORRICELLI AA,VIVEK S,SANTHIAGO MR,WILSON SE.The corneal epithelial basement membrane:structure,function,and disease[J].Invest Ophthalmol Vis Sci,2013,54(9):6390-6400.
[34] BALDWIN HC,MARSHALL J.Growth factors in corneal wound healing following refractive surgery:A review[J].Acta Ophthalmol Scand,2002,80(3):238-247.
[35] WILSON SE.Corneal myofibroblast biology and pathobiology:Generation,persistence,and transparency[J].Exp Eye Res,2012,99(1):78-88.
[36] GABISON EE,HUTE E,BAUDOUIN C,MENASHI S.Direct epithelial-stromal interaction in corneal wound healing:Role of EMMPRIN/CD147 in MMPs induction and beyond[J].Prog Retin Eye Res,2009,28(1):19-33.
[37] LEE JB,CHOE CM,KIM HS,SEO KY,SEONG GJ,KIM EK.Comparison of TGF-beta1 in tears following laser subepithelial keratomileusis and photorefractive keratectomy[J].J Refract Surg,2002,18(2):130-134.
[38] STRAMER BM,ZIESKE JD,JUNG JC,AUSTIN JS,FINI ME.Molecular mechanisms controlling the fibrotic repair phenotype in cornea:implications for surgical outcomes[J].Invest Ophthalmol Vis Sci,2003,44(10):4237-4246.
[39] NAKAMURA K,KUROSAKA D,BISSENMIYAJIMA H,TSUBOTA K.Intact corneal epithelium is essential for the prevention of stromal haze after laser assisted in situ keratomileusis[J].Br J Ophthalmol,2001,85(2):209-213.
[40] CHAURASIA SS,KAUR H,MEDEIROS FWD,SMITH SD,WILSON SE.Dynamics of the expression of intermediate filaments vimentin and desmin during myofibroblast differentiation after corneal injury[J].Exp Eye Res,2009,89(2):133-139.
[41] SINGH V,SANTHIAGO MR,BARBOSA FL,AGRAWAL V,SINGH N,AMBATI BK,et al.Effect of TGF-β and PDGF-B blockade on corneal myofibroblast development in mice[J].Exp Eye Res,2011,93(6):810-817.
[42] TULI SS,LIU R,CHEN C,BLALOCK TD,GOLDSTEIN M,SCHULTZ GS.Immunohistochemical localization of EGF,TGF-α,TGF-β,and their receptors in rat corneas during healing of excimer laser ablation[J].Curr Eye Res,2006,31(9):709-197.
[43] O’KANE S,FERGUSON MW.Transforming growth factor beta s and wound healing[J].Int J Biochem Cell Biol,1997,29(1):63-78.
[44] KRUMMEL TM,MICHNA BA,THOMAS BL,SPORN MB,NELSON JM,SALZBERG AM,et al.Transforming growth factor beta (TGF-β) induces fibrosis in a fetal wound model[J].J Pediatr Surg,1988,23(7):647-652.

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备注/Memo

备注/Memo:
 国家自然科学基金资助(编号:81060076、81360144)
更新日期/Last Update: 2017-03-01