[1]张利民,包秀丽.Sprouty调控转化生长因子-β信号通路介导的上皮间充质转化抑制后囊膜混浊的研究进展[J].眼科新进展,2019,39(7):690-694.[doi:10.13389/j.cnki.rao.2019.0159]
　ZHANG Li-Min,BAO Xiu-Li.Research progress of Sprouty regulates transform growth factor-β signaling pathway mediated epithelial mesenchymal transition and inhibits posterior capsular opacification[J].Recent Advances in Ophthalmology,2019,39(7):690-694.[doi:10.13389/j.cnki.rao.2019.0159]
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Sprouty调控转化生长因子-β信号通路介导的上皮间充质转化抑制后囊膜混浊的研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
39卷
期数:
2019年7期
页码:
690-694
栏目:
文献综述
出版日期:
2019-07-05

文章信息/Info

Title:
Research progress of Sprouty regulates transform growth factor-β signaling pathway mediated epithelial mesenchymal transition and inhibits posterior capsular opacification
作者:
张利民; 包秀丽
010100　内蒙古自治区呼和浩特市，内蒙古医科大学附属医院(张利民)；内蒙古医科大学附属医院眼科（包秀丽）
Author(s):
ZHANG Li-Min; BAO Xiu-Li
Affiliated Hospital of Inner Mongolia Medical University（ZHANG Li-Min），Hohhot 010100，Inner Mongolia Autonomous Region，China；Department of Ophthalmology,the Affiliated Hospital of Inner Mongolia Medical University(BAO Xiu-Li)，Hohhot 010100，Inner Mongolia Autonomous Region，China
关键词:
Sprouty; 后囊膜混浊; 上皮间充质转化; 转化生长因子-β; 晶状体上皮细胞; MAPK信号转导通路; 白内障
Keywords:
Sprouty; posterior capsular opacification; epithelial mesenchymal transition; TGF- β; lens epithelial cells; MAPK signaling pathways; cataract
分类号:
R776.1
DOI:
10.13389/j.cnki.rao.2019.0159
文献标志码:
A
摘要:
后囊膜混浊 (posterior capsular opacification，PCO) 是白内障手术的主要远期并发症，是由于手术切除纤维块后残留在囊袋中的晶状体上皮细胞（lens epithelial cell，LEC）的异常生长引起的。在成人术后2~5 a的发生率为20%~40%，儿童几乎为100%。大量研究表明LEC的上皮间充质转化(epithelial mesenchymal transition,EMT)及增殖过程是PCO发展的主要病理改变，转化生长因子-β（transform growth factor-β,TGF-β）信号通路参与了LEC的EMT过程，其包括经典的Smad信号通路及非Smad信号通路。丝裂原活化蛋白激酶（mitogen-activated protein kinase，MAPK）信号通路为主要的非Smad信号通路。Sprouty是RTK介导的Ras/ERK/MAPK 信号通路特异的抑制蛋白，并作为TGF-β诱导的EMT的负性调节因子抑制ERK信号通路，从而抑制EMT过程。本文将总结在PCO中LEC的EMT过程，以及Sprouty通过抑制TGF相关信号通路阻断PCO过程进行综述。
Abstract:
Posterior capsular opacification (PCO) is a major long-term complication of cataract surgery,and is caused by aberrant growth of lens epithelial cells（LECs） that are left behind in the capsular bag after surgical removal of the fiber mass.The incidence of postoperative 2-5 years is approximately 20%-40% in adults and almost 100% in children.A large number of studies have shown that epithelial mesenchymal transition (EMT) and proliferation of LECs are the main pathological changes in the development of PCO.TGF-β signaling pathway is involved in the EMT process of LECs.TGF- β signaling pathway includes canonical Smad signaling pathway and non Smad signaling pathway.The mitogen-activated protein kinase (MAPK) signaling pathway is the main non Smad signaling pathway.Sprouty is a specific inhibitor of the RTK-mediated Ras/ERK/MAPK signaling pathway and acts as a negative regulator of TGF-β induced EMT by inhibiting the ERK signaling pathway to inhibit the EMT process.A better understanding of the key cellular processes and molecular mechanisms of PCO may help to reduce the incidence of PCO,and the study of Sprouty may provide a useful therapeutic target for the prevention of EMT and cataract in the future.This review summarizes the EMT process of lens epithelial cells in PCO and Sprouty blocks the PCO process by inhibiting TGF-related signaling pathways.

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备注/Memo

备注/Memo:
国家自然科学基金资助（编号：81360145）
更新日期/Last Update: 2019-07-01