[1]靳荷,李霞.TGF-β在角膜瘢痕形成及无瘢痕愈合中的作用[J].眼科新进展,2014,34(11):1087-1090.[doi:10.13389/j.cnki.rao.2014.0302]
 JIN He,LI Xia.Role of TGF-β in corneal stromal scarring and scar-free wound healing[J].Recent Advances in Ophthalmology,2014,34(11):1087-1090.[doi:10.13389/j.cnki.rao.2014.0302]
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TGF-β在角膜瘢痕形成及无瘢痕愈合中的作用
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
34卷
期数:
2014年11期
页码:
1087-1090
栏目:
文献综述
出版日期:
2014-11-05

文章信息/Info

Title:
Role of TGF-β in corneal stromal scarring and scar-free wound healing
作者:
靳荷李霞
530021 广西壮族自治区南宁市,广西医科大学第一附属医院眼科
Author(s):
JIN He LI Xia
关键词:
转化生长因子-β角膜瘢痕角膜基质细胞创伤修复
Keywords:
TGF-β corneal scarring keratocytes wound healing
DOI:
10.13389/j.cnki.rao.2014.0302
文献标志码:
A
摘要:
转化生长因子β(transforminggrowthfactor-β,TGF-β)是一种多功能的细胞因子。体外和多种动物模型中研究已证实在角膜TGF-β是主要参与角膜损伤后启动瘢痕化的重要生长因子。近年来针对TGF-β抗瘢痕化研究已取得一些进展。本文综述了TGF-β分子结构、生物学功能,角膜损伤修复中瘢痕形成过程中基质细胞在TGF-β调控下的变化及TGF-β治疗角膜瘢痕的进展。
Abstract:
Transforming growth factor-β ( TGF-β ) is a multifunctional cytokine. It is well known that TGF-β is the most important cytokine in the procedure of corneal scarring after corneal injury. Recent years, some approaches of anti-scarring based on TGF-β have been reported. Understanding TGF-β is helpful for looking for those ways to eliminate corneal scarring. This article systematically reviews the literatures underlining the molecular structure and biological functions of TGF-β , the biological behavior of the keratocytes regulated by TGF-β during the corneal scarring and the approaches of scar-free wound healing of cornea based on TGF-β.

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备注/Memo

备注/Memo:
国家自然科学基金资助(编号:81060076、81360144);教育部留学回国人员科研启动基金项目(编号:200-1561)
更新日期/Last Update: 2014-11-11