[1]毕泗松,崔彦,毕宏生.视网膜血管内皮细胞在自身免疫性后葡萄膜炎中的作用[J].眼科新进展,2014,34(11):1091-1093.[doi:10.13389/j.cnki.rao.2014.0303]
 BI Si-Song,CUI Yan,BI Hong-Sheng.Role of retinal vascular endothelial cell in autoimmune posterior uveitis[J].Recent Advances in Ophthalmology,2014,34(11):1091-1093.[doi:10.13389/j.cnki.rao.2014.0303]
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视网膜血管内皮细胞在自身免疫性后葡萄膜炎中的作用
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
34卷
期数:
2014年11期
页码:
1091-1093
栏目:
文献综述
出版日期:
2014-11-05

文章信息/Info

Title:
Role of retinal vascular endothelial cell in autoimmune posterior uveitis
作者:
毕泗松崔彦毕宏生
250002 山东省济南市,山东中医药大学
Author(s):
BI Si-SongCUI YanBI Hong-Sheng
关键词:
视网膜血管内皮细胞自身免疫性后葡萄膜炎黏附分子趋化因子炎症反应
Keywords:
retinal vascular endothelial cell autoimmune posterior uveitis adhesion molecule chemokines inflammatory response
DOI:
10.13389/j.cnki.rao.2014.0303
文献标志码:
A
摘要:
视网膜血管内皮细胞(retinalvascularendothelialcell,RVEC)组成的微血管起到了对视网膜提供营养,排出代谢产物和保护视力的重要作用。另外,RVEC能保证血管内的物质循环,维持视网膜微血管的正常形态并且能阻止潜在的病原体侵入。RVEC还参与组成血-视网膜屏障,并排出微血管循环中的分子毒素、微生物和促炎因子。然而,正是因为具有这些特点,它也可能参与视网膜疾病的发生,例如新生血管、血管出血和炎症细胞。RVEC也可以参与后葡萄膜炎中缺血性病变的形成。本文就RVEC在自身免疫性后葡萄膜炎中的作用作一综述。
Abstract:
The microvessels composed by retinal vascular endothelial cells ( RVEC ) supply and drain the neural retina.and are consistent with nutritional requirements and protection of a tissue critical to vision. On the one hand , RVEC must ensure nutrients to the metabolically active retina. and allow access to circulating cells that maintain the vasculature or survey the retina for the presence of potential pathogens. On the other hand , RVEC contributes to the blood-retinal barrier that protects the retina by excluding circulating molecular toxins , microorganisms , and pro-inflammatory leukocytes. However , features required to fulfill these functions may also predispose to disease processes, such as retinal vascular leakage and neovascularization. Thus .RVEC is a key participant in retinal ischemic vasculopathies in posterior uveitis. This article reviews the role of RVEC in autoimmune posterior uveitis.

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备注/Memo

备注/Memo:
国家自然科学基金资助(编号:81100658、81373826、81072961);山东省自然科学基金资助(编号:2R2010HM048)
更新日期/Last Update: 2014-11-11