[1]李东丽,宫媛媛.间充质干细胞源性外泌体对前部缺血性视神经病变患者的治疗潜力[J].眼科新进展,2020,40(5):492-496.[doi:10.13389/j.cnki.rao.2020.0113]
 LI Dongli,GONG Yuanyuan.Therapeutic potential of mesenchymal stem cells-exosomes for anterior ischemic optic neuropathy[J].Recent Advances in Ophthalmology,2020,40(5):492-496.[doi:10.13389/j.cnki.rao.2020.0113]
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间充质干细胞源性外泌体对前部缺血性视神经病变患者的治疗潜力/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
40卷
期数:
2020年5期
页码:
492-496
栏目:
文献综述
出版日期:
2020-05-05

文章信息/Info

Title:
Therapeutic potential of mesenchymal stem cells-exosomes for anterior ischemic optic neuropathy
作者:
李东丽宫媛媛
200080 上海市,上海交通大学附属第一人民医院眼科
Author(s):
LI DongliGONG Yuanyuan
Department of Ophthalmology,Shanghai General Hospital,Shanghai Jiaotong University,School of Medicine,Shanghai 200080,China
关键词:
外泌体前部缺血性视神经病变间充质干细胞
Keywords:
xosomes anterior ischemic optic neuropathy mesenchymal stem cell
分类号:
R774.6
DOI:
10.13389/j.cnki.rao.2020.0113
文献标志码:
A
摘要:
前部缺血性视神经病变(anterior ischemic optic neuropathy,AION)是继青光眼后成人永久性视神经相关视力丧失的第二大常见原因,目前尚无确切有效的治疗方案。既往研究发现间充质干细胞源性外泌体(mesenchymal stem cells-exosomes,MSC-exosomes)与MSCs非常相似地改善缺血后神经组织的损伤,并诱导与增强血管神经发生相关的长期神经保护作用。外泌体是细胞-细胞间交流的一种重要通讯途径,因此可作为小分子物质传递载体信号,并通过不同机制作用于靶细胞,从而成为眼前部缺血性视神经病变潜在的有效治疗工具。本文对MSC-exosomes 的生物发生及其功能,以及MSC-exosomes在前部缺血性视神经性病变中的治疗机制进行综述。
Abstract:
Anterior ischemic optic neuropathy (AION) is the second most common cause of permanent vision loss after glaucoma. There is no actual and effective treatment plan. Mesenchymal stem cells-exosomes (MSC-exosomes) have been shown to significantly attenuate post-ischemic neuronal damage and induce long-term neuroprotection associated with enhanced angiogenesis of MSCs. Exosomes are an important communication pathway for cell-cell communication, and can be used as a small molecule to transmit carrier signals and act on the target cells by different mechanisms. Therefore, MSC-exosomes are expected to be an effective therapeutic tool for the treatment of AION. This article reviews the biogenesis and physiological functions of MSC-exosomes, and their therapeutic mechanism for AION.

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备注/Memo

备注/Memo:
国家重点研发计划资助(编号:2016YFC0904800);上海市第一人民医院临床研究创新团队建设项目资助(编号:CTCCR-2018BP04);上海市科学技术委员会科研计划项目(编号:19401932700)
更新日期/Last Update: 2020-05-05