[1]张妍,邵正波.视网膜损伤：外泌体转录组学的研究进展[J].眼科新进展,2023,43(2):165-168.[doi:10.13389/j.cnki.rao.2023.0033]
　ZHANG Yan,SHAO Zhengbo.Research advances in the exosome transcriptomics in retinal injury[J].Recent Advances in Ophthalmology,2023,43(2):165-168.[doi:10.13389/j.cnki.rao.2023.0033]
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视网膜损伤：外泌体转录组学的研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
43卷
期数:
2023年2期
页码:
165-168
栏目:
文献综述
出版日期:
2023-02-05

文章信息/Info

Title:
Research advances in the exosome transcriptomics in retinal injury
作者:
张妍; 邵正波
150086　黑龙江省哈尔滨市，哈尔滨医科大学附属第二医院眼科，哈尔滨医科大学附属第二医院未来医学实验室
Author(s):
ZHANG Yan; SHAO Zhengbo
Department of Ophthalmology,Future Medical Laboratory,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,Heilongjiang Province,China
关键词:
转录组学; 外泌体; 视网膜损伤; 视网膜细胞; 视网膜血管
Keywords:
transcriptomics;  exosome;  retinal injury;  retinal cells;  retinal vessels
分类号:
R774
DOI:
10.13389/j.cnki.rao.2023.0033
文献标志码:
A
摘要:
衰老、缺氧、高糖刺激等多种因素导致的视网膜损伤过程中，外泌体发挥着重要作用。外泌体是一种纳米级的细胞外囊泡，包含微小RNA、环状RNA等多种转录产物，广泛参与视网膜色素上皮细胞损伤、新生血管形成、视网膜神经节细胞和光感受器细胞凋亡等过程。通过转录组学分析外泌体对视网膜损伤及修复的调控机制，识别糖尿病视网膜病变、青光眼等眼科疾病相关分子生物标志物，寻找新的治疗靶点，已成为视网膜研究的热点。因此，本文对外泌体转录组学在视网膜损伤中的研究进展进行综述。
Abstract:
Exosomes play an essential role in retinal injury caused by aging, hypoxia, high glucose stimulation and other factors. Exosomes are nanoscale extracellular vesicles containing micro ribonucleic acid, circular ribonucleic acid and other transcription products, which are widely involved in the pathological processes of retinal pigment epithelial cell injury, neovascularization, retinal ganglion cell and photoreceptor cell apoptosis. Transcriptome analysis of the regulatory mechanism of exosomes involved in retinal injury and repair, identification of molecular biomarkers related to eye diseases such as diabetic retinopathy and glaucoma, and search for new therapeutic targets have become the hotspots of retinal research. Therefore, this review focuses on the research progress of exosome transcriptomics in retinal injury.

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备注/Memo

备注/Memo:
国家自然科学基金项目（编号：81970799，81870654）；黑龙江省博士后科研启动基金（编号：LBH-Q18082）
更新日期/Last Update: 2023-02-05