[1]陈熹,陈水莲,余克明,等.外泌体及其与眼科疾病的免疫学关系[J].眼科新进展,2019,39(11):1087-1090.[doi:10.13389/j.cnki.rao.2019.0250]
　CHEN Xi,CHEN Shui-Lian,YU Ke-Ming,et al.Immunological relationship between exosomes and ophthalmic diseases[J].Recent Advances in Ophthalmology,2019,39(11):1087-1090.[doi:10.13389/j.cnki.rao.2019.0250]
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外泌体及其与眼科疾病的免疫学关系/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
39卷
期数:
2019年11期
页码:
1087-1090
栏目:
文献综述
出版日期:
2019-11-05

文章信息/Info

Title:
Immunological relationship between exosomes and ophthalmic diseases
作者:
陈熹; 陈水莲; 余克明; 庄菁
510060　广东省广州市，中山大学中山眼科中心
Author(s):
CHEN Xi; CHEN Shui-Lian; YU Ke-Ming; ZHUANG Jing
State Key Laboratory of Ophthalmology，Zhongshan Ophthalmic Center，Sun Yat-sen University，Guangzhou 510060，Guangdong Province，China
关键词:
外泌体; 眼科疾病; 免疫调节; 治疗
Keywords:
exosomes; ophthalmic diseases; immune regulation; therapy
分类号:
R77
DOI:
10.13389/j.cnki.rao.2019.0250
文献标志码:
A
摘要:
外泌体是细胞内多囊泡体与细胞膜融合后主动分泌到胞外的纳米级小囊泡。外泌体能够通过其携带的蛋白质或RNA影响免疫调控网络，进而影响眼内细胞的生理或病理过程。干细胞或眼内细胞分泌的外泌体在一些眼科疾病的发病及损伤修复机制中起重要的免疫调控作用。本文就外泌体的来源与特性、外泌体在眼科疾病中发挥的免疫学作用展开讨论，从而为进一步揭示外泌体免疫调节作用机制及治疗策略提供参考资料。
Abstract:
Exosomes are nanosized small membrane microvesicles,which secreted automatically from multivesicular bodies into extracellular matrix after multivesicular bodies fusing with plasma membrane.Exosomes,through its carrying protein or RNA from derived cells,can affect immune regulation networks,and then influence the physiological and pathological processes of cells in the eye.Exosomes secreted by stem cells and cells in the eye play a significant immune regulatory role in pathogenesis and damage repair mechanism of some ophthalmic diseases.Many studies on the origin,features and immunological function of exosomes are reviewed.The review would be helpful to further researches on exosome-mediated mechanisms of immune regulation and therapy of the onset and development of ophthalmic diseases.

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更新日期/Last Update: 2019-11-18