[1]赵露,洪慧,谢国丽,等.玻璃体内注射雷珠单抗对湿性年龄相关性黄斑变性患者脉络膜厚度及睫状后动脉血流的影响[J].眼科新进展,2016,36(8):745-747.[doi:10.13389/j.cnki.rao.2016.0198]
　ZHANG Lu,HONG Hui,XIE Guo-Li,et al.Effects of intravitreal ranibizumab injection on subfoveal choroidal thickness and posterior ciliary artery hemodynamics in patients with wet age-related macular degeneration[J].Recent Advances in Ophthalmology,2016,36(8):745-747.[doi:10.13389/j.cnki.rao.2016.0198]
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玻璃体内注射雷珠单抗对湿性年龄相关性黄斑变性患者脉络膜厚度及睫状后动脉血流的影响
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年8期
页码:
745-747
栏目:
应用研究
出版日期:
2016-08-05

文章信息/Info

Title:
Effects of intravitreal ranibizumab injection on subfoveal choroidal thickness and posterior ciliary artery hemodynamics in patients with wet age-related macular degeneration
作者:
赵露; 洪慧; 谢国丽; 王艳玲
100050　北京市，首都医科大学附属北京友谊医院眼科
Author(s):
ZHANG Lu ;  HONG Hui; XIE Guo-Li ;  WANG Yan-Ling
Department of Ophthatmology , Beijing Friendship Hospital , Capital Medical University, Beijing 100050 , China
关键词:
脉络膜厚度; 睫状后动脉; 血流动力学; 雷珠单抗; 年龄相关性黄斑变性
Keywords:
choroidal thickness ;  posterior ciliary artery ;  hemodynamics ;  ranibizumab ;  age-related macular degeneration
分类号:
Ｒ７７３
DOI:
10.13389/j.cnki.rao.2016.0198
文献标志码:
A
摘要:
目的　观察湿性年龄相关性黄斑变性患者经单独玻璃体内注射雷珠单抗治疗后脉络膜厚度及睫状后动脉血流的变化。方法　纳入２０例（２０眼）患者。所有患者治疗前及治疗后１周、４周记录睫状后动脉血流动力学参数，包括收缩期峰值流速、舒张末期血流速度、阻力指数及搏动指数；采用ＳｐｅｃｔｒａｌｉｓＯＣＴ的ＥＤＩ技术，测量中心凹下脉络膜厚度和视网膜中心厚度。比较患者治疗前后不同时间点各指标的差异性。结果　治疗前、治疗后１周及治疗后４周视网膜中心厚度分别为（３９６．４７±９５．２０）μｍ、（３６４．３３±８７．２１）μｍ、（３２７．９３±６２．８６）μｍ，治疗前后比较差异均有统计学意义。治疗前、治疗后１周及治疗后４周最佳矫正视力分别为（０．８０±０．４６）ＬｏｇＭＡＲ、（０．５６±０．２７）ＬｏｇＭＡＲ、（０．４７±０．２１）ＬｏｇＭＡＲ，治疗前后比较差异均具有统计学意义。治疗前、治疗后１周及治疗后４周中心凹下脉络膜厚度分别为（２５６．６４±５７．１１）μｍ、（２５１．３７±５６．７６）μｍ、（２４８．２７±５６．２２）μｍ，治疗前后比较差异均具有统计学意义。治疗后１周、４周与治疗前比较睫状后动脉的收缩期峰值流速、舒张末期血流速度、阻力指数及搏动指数差异均无统计学意义。结论　湿性年龄相关性黄斑变性患者单独玻璃体内注射雷珠单抗会引起中心凹下脉络膜厚度降低，但不影响睫状后动脉的血流。
Abstract:
Objective To observe the changes of choroidal thickness and posterior ciliary artery ( PCA) hemodynamics in patients who had undergone a single intravitreal ranibizumab injection for wet age-related macular degeneration ( wAMD) . Methods Twenty wAMD patients (20 eyes) who had undergone intravitreal 0. 5 mg ranibizumab injection were enrolled in this study. PCA of patients were evaluated by color Doppler sonography. Peak systolic velocity ( PSV) ,end-diastolic velocity ( EDV) .resistance index ( RI) and pulsatility index ( PI) values were calculated before injection and I week,4 weeks after injection. Enhanced depth imaging on Spectralis optical coherence tomography was used to measure the subfoveal choroidal thickness ( SFCT) and central retinal thickness ( CRT ) . The differences of SFCT and posterior ciliary artery hemodynamic parameters were analyzed before injection and I week,4 weeks after injection. Results CRT before injection and I week.4 weeks after injection were ( 396. 47 + 95. 20 ) lLm , ( 364. 33 + 87. 21 ) ym , ( 327. 93 + 62. 86 ) ym , respectively , and the differences were significant. The visual acuity before injection and I week.4 weeks after injection were ( 0. 80 +0. 46) logMAR , ( 0. 56 + 0. 27 ) logMAR , ( 0. 47 + 0. 21 ) logMAR , respectively , and the differences were significant. SFCT before injection and I week,4 weeks after injection were ( 256. 64 + 57. 11) ym , ( 25 1. 37 + 56. 76) ym, ( 248. 27 + 56. 22 ) ym , respectively, and the differences were sigruficant. Compared with pre-injection , the values of PSV , EDV , RI and PI at I week,4 weeks after injection showed no statistically sigruficant difference in PCA. Conclusion Intravitreal ranibizumab injection for wAMD cause the decreases of SFCT ,but don ’ t affect the PCA hemodynamics.

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更新日期/Last Update: 2016-08-22