[1]罗铭,李红阳,马胜生,等. 青少年高度近视眼的脉络膜厚度改变[J].眼科新进展,2015,35(5):449-452.[doi:10.13389/j.cnki.rao.2015.0122]
　LUO Ming,LI Hong-Yang,MA Sheng-Sheng,et al. Changes of choroidal thickness in adolescent high myopia[J].Recent Advances in Ophthalmology,2015,35(5):449-452.[doi:10.13389/j.cnki.rao.2015.0122]
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 青少年高度近视眼的脉络膜厚度改变
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年5期
页码:
449-452
栏目:
应用研究
出版日期:
2015-05-05

文章信息/Info

Title:
 Changes of choroidal thickness in adolescent high myopia
作者:
 罗铭; 李红阳; 马胜生; 梁纳
 510220　广东省广州市，暨南大学医学院第四附属医院（广州市红十字会医院）眼科
Author(s):
 LUO Ming ;  LI Hong-Yang ;  MA Sheng-Sheng ;  LIANG Na
 Department of Ophthalmology,School of Medicine,the Fourth Affiliated Hospital of Jinan University, Cuangzhou Red Cross Hospital,Guangzhou 510220,Guangdong Province, China
关键词:
 ; 脉络膜厚度; 加强深度扫描; 光学相干断层扫描; 高度近视; 青少年
Keywords:
 ; choroidal thickness ;  enhanced depth imaging;  optical coherence tomography ;  high myopia ;  adolescent
DOI:
10.13389/j.cnki.rao.2015.0122
文献标志码:
A
摘要:
 目的　比较青少年高度近视眼与正常眼的脉络膜厚度的差异，分析脉络膜厚度变化与青少年高度近视的关系。方法　选取２０１４年２月至２０１４年８月在我院眼视光中心就诊和体检的青少年６２例１１１眼，年龄为１３～１７（１４．３４±２．７４）岁。分为高度近视组３２例５７眼，正常对照组３０例５４眼，高度近视组屈光度（－６．８５±１．１４）Ｄ，眼轴（２６．３１±１．１３）ｍｍ。正常对照组屈光度（－０．３７±０．８５）Ｄ，眼轴（２３．９１±０．６４）ｍｍ。两组间的屈光度、眼轴差异均有统计学意义（Ｐ＜０．００１）。采用频域光学相干断层扫描的加强深度扫描技术对黄斑部进行０°扫描，测量黄斑中心凹下及由中心凹向鼻侧和颞侧３０００μｍ的脉络膜厚度值，共测量１３个子午线，每个子午线间隔５００μｍ，比较两组间脉络膜厚度、屈光度和眼轴，分析脉络膜厚度变化与青少年高度近视的关系。结果　青少年高度近视组受检眼黄斑中心凹下脉络膜厚度值和黄斑部脉络膜平均厚度值分别为（２２０．４±４９.６）μｍ和（２０９．９±６２．８）μｍ，正常对照组分别为（３４７．４±６３．６）μｍ和（２９５．１±７１．２）μｍ，两组间差异均有统计学意义（ｔ＝－１７.２２０，Ｐ＝０．０００；ｔ＝－１６．１８０，Ｐ＝０．０００）。青少年高度近视组颞侧脉络膜最厚，中心凹下厚度次之，鼻侧最薄；而正常对照组以黄斑中心凹区域脉络膜最厚，其次为颞侧，鼻侧最薄。高度近视组受检眼各检测点脉络膜均薄于正常对照组。两组脉络膜厚度的差异黄斑中心凹区域较黄斑周边区域明显（Ｐ＜０．００１）。结论　青少年高度近视患者脉络膜厚度较青少年正常眼明显变薄，以黄斑中心凹区域的差异显著。提示脉络膜的厚度改变可能在青少年高度近视眼的发生过程中发挥作用。
Abstract:
 Objective To analyze the correlation between choroidal thickness and adolescent high myopia by examining the choroidal thickness in high myopic and normal adolescent. Methods Total of 62 subjects aged 13 years t0 17 years ( 14. 34 + 2. 74) years were examined in Guangzhou Red Cross Hospital from February to August of 2014. There were 57 eyes of 32 subjects in the high myopia group , whose spherical equivalent refraction was ( - 6. 85 + 1. 14 ) D. and axis length was ( 26. 31 + 1. 13) mm. Another 54 eyes of 30 subjects in the normal control group ,whose spherical equivalent refraction was ( - 0. 37 + 0. 85 ) D . and axis length was ( 23. 91 + 0. 64 ) mm. Cirrus spectral-domain optical coherence tomography ( SD-OCT) with enhanced depth imaging ( EDI) capability was used to measure choroidal thickness at subfovea, and at the nasal and temporal sides of the fovea along 13 meridians with a 500 Vm interval ( ranging a total distance of 6000 Vm ) . The spherical equivalent refraction . axial length , and choroidal thickness were compared between the high myopia group and normal group , and the relationship between choroidal thickness and high myopia was analyzed. Results The choroidal thickness at subfovea. and average macular choroidal thickness in the high myopia group were ( 220. 4 + 49. 6) Vm and ( 209. 9 + 62. 8 ) ym , respectively , which in the normal group were ( 347. 4 +63. 6) ym and ( 295. I +71. 2) ym , respectively , there were significant differences between two groups ( t = - 17. 220 ,P = 0. 000 ; t = - 16. 180 ,P = 0. 000) . For the high myopia group, choroid was thickest in the temporal regions, followed by subfovea. and thinnest in the nasal side , while in the normal control group , choroid was thickest in subfovea, followed by temporal regions , and thinnest in the nasal side. The choroidal thickness in vanous areas were thinner in the high myopia group compared to corresponding locations in the normal control group. The differences in choroidal thickness between high myopia and normal control group were sigruficantly greater in central foveal regions compared to peripheral regions ( P < 0. 001 ) . Conclusion High myopic adolescent have significantly thinner choroids compared to normal adolescent of similar ages , particularly in central foveal region. These findings indicate that abnormalities of the choroids may play a role in the pathogenesis of high myopia in adolescent.

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备注/Memo

备注/Memo:
 广东省医学科学技术研究基金（编号：ＷＳＴＪＪ２０１４-０１２０４４０１０４１９６３０７２１３７１４）
更新日期/Last Update: 2015-04-27