[1]任若昕,管怀进,季敏.晶状体上皮细胞葡萄糖代谢的研究进展[J].眼科新进展,2023,43(5):412-416.[doi:10.13389/j.cnki.rao.2023.0083]
　REN Ruoxin,GUAN Huaijin,JI Min.Research progress in glucose metabolism of lens epithelial cell[J].Recent Advances in Ophthalmology,2023,43(5):412-416.[doi:10.13389/j.cnki.rao.2023.0083]
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晶状体上皮细胞葡萄糖代谢的研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
43卷
期数:
2023年5期
页码:
412-416
栏目:
文献综述
出版日期:
2023-05-05

文章信息/Info

Title:
Research progress in glucose metabolism of lens epithelial cell
作者:
任若昕; 管怀进; 季敏
226001　江苏省南通市，南通大学附属医院眼科研究所（任若昕，管怀进，季敏）；116000　辽宁省大连市，大连医科大学（任若昕）
Author(s):
REN Ruoxin1; 2; GUAN Huaijin1; JI Min1
1.Eye Institute，Affiliated Hospital of Nantong University，Nantong 226001，Jiangsu Province，China
2.Dalian Medical University，Dalian 116000，Liaoning Province，China
关键词:
糖尿病性白内障; 葡萄糖代谢; 晶状体上皮细胞
Keywords:
diabetic cataract;  glucose metabolism;  lens epithelial cells
分类号:
R776
DOI:
10.13389/j.cnki.rao.2023.0083
文献标志码:
A
摘要:
糖尿病性白内障（DC）是影响糖尿病患者视力的重要原因，其发病机制尚未完全明确。研究表明，葡萄糖代谢紊乱可能是DC形成的重要机制。晶状体上皮细胞(LECs)是晶状体代谢最为活跃的成分，正常的葡萄糖代谢对维持晶状体透明至关重要。在高糖环境下，LECs发生葡萄糖代谢紊乱可能是DC发生发展的重要机制。本文就正常和高糖条件下LECs葡萄糖代谢的特点及其对LECs的影响进行综述，以期为DC的防治提供新的思路。
Abstract:
Diabetic cataract (DC) is an important cause of visual impairment in diabetic patients. However, its pathogenesis has not been completely understood. Studies have shown that glucose metabolic disorders may be an essential mechanism for DC. Lens epithelial cells (LECs) are the most active component of lens metabolism. Normal glucose metabolism is essential for maintaining lens transparency. The glucose metabolism of LECs may be disturbed by high glucose, which may play a significant role in the development of DC. This paper summarizes the characteristics of glucose metabolism in LECs under normal and high glucose conditions and their impact on LECs to provide new ideas for the prevention and treatment of DC.

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备注/Memo

备注/Memo:
国家自然科学基金资助（编号：82171038）；江苏省卫生健康委科研资助（编号：M2021084）；南通市科技项目资助（编号：MS22022020）
更新日期/Last Update: 2023-05-05