[1]周单,董如亚,郑青青,等.生长激素缺乏症患儿和正常儿童屈光状态的比较研究[J].眼科新进展,2022,42(3):218-221.[doi:10.13389/j.cnki.rao.2022.0044]
　ZHOU Dan,DONG Ruya,ZHENG Qingqing,et al.Comparison of refractive state between child patients with growth hormone deficiency and the controls[J].Recent Advances in Ophthalmology,2022,42(3):218-221.[doi:10.13389/j.cnki.rao.2022.0044]
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生长激素缺乏症患儿和正常儿童屈光状态的比较研究/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
42卷
期数:
2022年3期
页码:
218-221
栏目:
应用研究
出版日期:
2022-03-05

文章信息/Info

Title:
Comparison of refractive state between child patients with growth hormone deficiency and the controls
作者:
周单; 董如亚; 郑青青; 沈婷; 洪朝阳
233030　安徽省蚌埠市，蚌埠医学院（周单，董如亚）；310014　浙江省杭州市，浙江省人民医院（郑青青，洪朝阳）；310014　浙江省杭州市，浙江大学医学院附属第二医院（沈婷）
Author(s):
ZHOU Dan1; DONG Ruya1; ZHENG Qingqing2; SHEN Ting3; HONG Chaoyang2
1.Bengbu Medical College,Bengbu 233030,Anhui Province,China
2.Department of Ophthalmology,Zhejiang Provincial People’s Hospital,Hangzhou 310014,Zhejiang Province,China
3.The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,Zhejiang Province,China
关键词:
生长激素缺乏症; 角膜曲率; 等效球镜度; 年龄
Keywords:
growth hormone deficiency;  corneal curvature;  spherical equivalent;  age
分类号:
R778.1
DOI:
10.13389/j.cnki.rao.2022.0044
文献标志码:
A
摘要:
目的　分析生长激素缺乏症（GHD）患儿和正常儿童屈光发育情况并探究生长激素缺乏对眼部屈光发育的影响，为该疾病导致眼部屈光发育异常的诊疗提供重要参考。方法　病例对照研究。选取2020年6月至2021年11月在浙江省人民医院儿科内分泌门诊确诊为GHD的6~13岁72例患儿纳入研究，作为GHD组。按年龄再分成4组，分别为6~7岁组、8~9岁组、10~11岁组和12~13岁组。将与GHD组的性别、年龄特征相匹配的70位（140眼）正常儿童作为对照组，按同样的年龄分段对对照组儿童进行分组。通过光学生物测量仪（IOLMaster）及睫状肌麻痹验光获得眼轴长度、等效球镜度（SE）与角膜曲率。定量资料组间差异使用t检验，定性资料组间差异采用χ2检验,相关性分析使用多元线性回归分析。结果　GHD组患儿平均远视患病率为13.9%，对照组为11.4%，GHD组患儿的SE为（-0.59±1.39）D，对照组为（-0.86±1.44）D，GHD患儿的SE与眼轴长度、角膜曲率均呈负相关关系（r=-7.43、-4.55，均为P<0.001）。结论　生长激素缺乏可影响儿童眼部屈光系统的发育，GHD患儿远视患病率高于正常儿童，眼轴长度较正常儿童的短，角膜曲率较正常儿童偏高。
Abstract:
Objective　To analyze the refractive development of child patients with growth hormone deficiency (GHD) and the controls, and explore the influence of GHD on ocular refractive development, so as to provide an important reference for the diagnosis and treatment of GHD-induced refractive errors.Methods　In this case-control study, 72 child patients,aged 6-13 years who were diagnosed as GHD in the Pediatric Endocrinology Clinic of Zhejiang Provincial People’s Hospital from June 2020 to November 2021 were selected into the GHD group. They were divided into 4 groups according to their ages, namely 6-7, 8-9, 10-11, and 12-13 groups. Another 70 controls matched with the GHD group in gender and age were selected into the control group, and they were divided into 4 groups according to the same age groups. The axial length (AL), spherical equivalent (SE) and corneal curvature were obtained by IOLMaster and cycloplegic refraction. The difference in quantitative data between groups was tested by t test, and the difference in qualitative data between groups was tested by χ2 test. The correlation was analyzed by multiple linear regression.Results　The average prevalence of hyperopia reached 13.9% in the GHD group and 11.4% in the control group. The average SE was (-0.59±1.39) D in the GHD group and (-0.86±1.44) D in the control group. The SE of GHD children was negatively correlated with AL and corneal curvature (r=-7.43,-4.55; both P<0.001).Conclusion　GHD affects the development of the refractive system in children. The prevalence of hyperopia and corneal curvature in GHD children are both higher than those in the controls, while the AL is shorter than that in the controls.

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备注/Memo

备注/Memo:
浙江省医药卫生科技计划项目（编号：2021KY469）
更新日期/Last Update: 2022-03-05