[1]郑丹,庞东渤.应用光学相干断层扫描血管成像（OCTA）评估糖尿病患者早期黄斑区视网膜微循环[J].眼科新进展,2018,38(6):548-552.[doi:10.13389/j.cnki.rao.2018.0128]
　ZHENG Dan,PANG Dong-Bo.Evaluation of early macular retinal microcirculation in diabetic patients using optical coherence tomography angiography[J].Recent Advances in Ophthalmology,2018,38(6):548-552.[doi:10.13389/j.cnki.rao.2018.0128]
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应用光学相干断层扫描血管成像（OCTA）评估糖尿病患者早期黄斑区视网膜微循环/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
38卷
期数:
2018年6期
页码:
548-552
栏目:
应用研究
出版日期:
2018-06-05

文章信息/Info

Title:
Evaluation of early macular retinal microcirculation in diabetic patients using optical coherence tomography angiography
作者:
郑丹; 庞东渤
121000　辽宁省锦州市，锦州医科大学附属第一医院眼科
Author(s):
ZHENG Dan; PANG Dong-Bo
Ophthalmology，the First Affiliated Hospital of Jinzhou Medical University，Jinzhou 121000，Liaoning Province，China
关键词:
光学相干断层扫描血管成像; 黄斑中心凹无血管区; 黄斑区血流密度; 糖尿病视网膜病变
Keywords:
optical coherence tomography angiography;  foveal avascular zone;  macular vascular density;  diabetic retinopathy
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2018.0128
文献标志码:
A
摘要:
目的　应用光学相干断层扫描血管成像（optical coherence tomography angiography，OCTA）观察糖尿病患者早期黄斑中心凹无血管区（foveal avascular zone，FAZ）面积和黄斑区血流密度（macular vascular density，MVD）的改变及其临床意义。方法　回顾性病例研究。收集33例46眼糖尿病患者纳入研究，依据糖尿病视网膜病变国际临床分期标准将患眼分为两组，其中无糖尿病视网膜病变（no-diabetic retinopathy，NDR）组13例20眼和非增生期糖尿病视网膜病变（nonproliferative diabetic retinopathy，NPDR）组20例26眼。另选取年龄相匹配的26人（40眼）健康者作为对照组。所有受试者均接受OCTA对黄斑区视网膜行3 mm×3 mm 范围的模式扫描，获得4个层面黄斑血流密度图，同时测量FAZ面积和MVD。结果　NDR组和NPDR组FAZ面积分别为（0.392±0.028）mm2、（0.410±0.019）mm2，与对照组（0.314±0.025）mm2相比差异均有统计学意义（均为P=0.000）；NDR组和NPDR组之间的FAZ面积比较，差异有统计学意义（P=0.010）。NDR组和NPDR组的表层视网膜、深层视网膜、外层视网膜及脉络膜毛细血管层的MVD分别是0.500±0.012、0.553±0.007、0.393±0.005、0.651±0.006和0.484±0.012、0.522±0.007、0.397±0.007、0.642±0.007，与对照组（0.518±0.014、0.572±0.008、0.385±0.005、0.666±0.007）比较，差异均有统计学意义（均为P=0.000）；NDR组和NPDR组表层视网膜、深层视网膜及脉络膜毛细血管层MVD比较，差异均有统计学意义（均为P=0.000），但两组外层视网膜MVD比较，差异无统计学意义（P=0.065）。结论　应用OCTA检查提示糖尿病患者早期黄斑区视网膜的微循环障碍，且随着病情的进展而变化。
Abstract:
Objective　To observe the early changes in the area of the foveal avascular zone （FAZ） and macular vascular density （MVD） in diabetic patients using optical coherence tomography angiography （OCTA） and its clinical significance.Methods　This was a retrospective study.Totally 33 patients with diabetes mellitus were enrolled，including 13 patients with no-diabetic retinopathy （NDR group） and 20 patients with nonproliferative diabetic retinopathy （NPDR group） according to the international clinical grading criteria of diabetic retinopathy.Additional 26 healthy subjects with matched age were enrolled in the control group.All the subjects underwent the 3 mm×3 mm scanning of macular retina by OCTA for obtaining 4 levels of macular vascular density map.And the area of the FAZ and the MVD were measured.Results　The area of FAZ was（0.392±0.028）mm2 in the NDR group and （0.410±0.019）mm2 in the NPDR group，respectively，and the difference was statistically significant compared with the control group （0.314 ± 0.025）mm2 （all P=0.000），and there was statistically significant difference between the NDR group and NPDR group （P=0.010）.The MVD in the superficial retinal layer，deep retinal layer，outer retinal layer and choroidal capillary layer was 0.500±0.012，0.553±0.007，0.393±0.005，0.651±0.006 in the NDR group，and 0.484±0.012，0.522±0.007，0.397±0.007，0.642±0.007 in the NPDR group，respectively，and the difference was statistically significant compared with the control group （0.518±0.014，0.572±0.008，0.385±0.005，0.666±0.007） （all P=0.000）； there were statistically significant differences in MVD between the NDR group and NPDR group in the superficial retinal layer，deep retinal layer and choroidal capillary layer （all P= 0.000），but not in the outer retinal layer （P=0.065）.Conclusion　OCTA suggested that the early retinal microcirculation impairment in the macula in patients with diabetes，which changes with the progression of the disease.

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备注/Memo

备注/Memo:
辽宁省科技厅基金项目 （编号：2015020361）
更新日期/Last Update: 2018-07-10