[1]冷云霞,张柳,张蒙,等.早产儿视网膜病变黄斑中心视网膜微血管形态特征：基于光学相干断层扫描血管成像（OCTA）的观察[J].眼科新进展,2018,38(4):357-360.[doi:10.13389/j.cnki.rao.2018.0083]
　LENG Yun-Xia,ZHANG Liu,ZHANG Meng,et al.Observation of central macular retinal microvascular network morphology of retinopathy of prematurity by optical coherence tomography angiography[J].Recent Advances in Ophthalmology,2018,38(4):357-360.[doi:10.13389/j.cnki.rao.2018.0083]
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早产儿视网膜病变黄斑中心视网膜微血管形态特征：基于光学相干断层扫描血管成像（OCTA）的观察/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
38卷
期数:
2018年4期
页码:
357-360
栏目:
应用研究
出版日期:
2018-04-05

文章信息/Info

Title:
Observation of central macular retinal microvascular network morphology of retinopathy of prematurity by optical coherence tomography angiography
作者:
冷云霞; 张柳; 张蒙; 吴敏; 蔡诚; 任国梁; 高宗银
510084　广东省广州市，广州市第一人民医院眼科，华南理工大学附属第二医院眼科
Author(s):
LENG Yun-Xia; ZHANG Liu; ZHANG Meng; WU Min; CAI Cheng; REN Guo-Liang; GAO Zong-Yin
Department of Ophthalmology，Guangzhou First People’s Hospital，the Second Affiliated Hospital of South China University of Technology，Guangzhou 510084，Guangdong Province，China
关键词:
早产儿视网膜病变; 光学相干断层扫描血管成像; 黄斑中心凹无血管区; 表层视网膜血管网; 黄斑中心凹视网膜厚度
Keywords:
retinopathy of prematurity; optical coherence tomography angiography; foveal avascular zone; superficial retinal capillary plexus; central foveal thickness
分类号:
R774.5
DOI:
10.13389/j.cnki.rao.2018.0083
文献标志码:
A
摘要:
目的　采用光学相干断层扫描血管成像（optical coherence tomography angiography，OCTA）观察并分析早产儿视网膜病变（retinopathy of prematurity，ROP）患儿黄斑中心视网膜微血管网的特征。方法　采用横断面研究，选取有ROP激光治疗病史的7~15岁ROP患儿14例25眼设为ROP组及年龄相对应的足月出生儿童20例40眼设为对照组。使用RTVue XR Avanti-OCTA等仪器对两组儿童的最佳矫正视力（best corrected visual acuity，BCVA）、黄斑中心凹视网膜厚度（central foveal thickness，CFT）、黄斑中心凹无血管区（foveal avascular zone，FAZ）面积、表层视网膜血管网（superficial retinal capillary plexus，SCP）密度等指标进行检查。采用两独立样本t检验进行统计分析。结果　ROP组和对照组患儿的FAZ面积分别为（0.04±0.05）mm2和（0.29±0.08）mm2，组间差异有统计学意义（P<0.001）。ROP组和对照组的SCP密度分别为42.70%±5.90%和35.90%±6.30%，组间差异有统计学意义（P<0.010）。ROP组和对照组的CFT分别为（328.50±34.90）μm和（236.80±23.40）μm，组间差异有统计学意义（P<0.001）。ROP组和对照组患儿BCVA分别为0.83±0.14和0.85±0.26，组间差异无统计学意义（P>0.05）。结论　ROP组患儿具有更小或没有形成明显的FAZ，同时伴有CFT增厚和SCP密度增加；FAZ面积及CFT对ROP患儿BCVA无明显影响。
Abstract:
Objective　To analyze the characteristics of central macular retinal microvascular network morphology of retinopathy of prematurity(ROP) with optical coherence tomography angiography(OCTA).Methods　The 7-15 years old ROP children with laser treatment history(ROP group，25 eyes of 14 patients ) and full-term children(control group，40 eyes of 20 patients ) were collected by cross-sectional study.The subjects in the two groups were examined by RTVue XR Avanti-OCTA，and several parameters including the detection of the best corrected visual acuity(BCVA)，central foveal thickness (CFT)，foveal avascular zone (FAZ)，macular superficial retinal capillary plexus (SCP) density were recorded and analyzed statistically with t test in the two groups.Results　The area of FAZ in ROP group was (0.04±0.05)mm2，which was significantly less than that in control group ［(0.29±0.08)mm2］ (P<0.001).The SCP density of ROP group was 42.70%±5.90%，which was significantly higher than that in the control group (35.90%±6.30%) (P<0.001).The CFT in ROP group was (328.50±34.90)μm，which was significantly higher than that in the control group ［(236.80±23.40)μm］(P<0.001).The BCVA was 0.83±0.14 in ROP group and 0.85±0.26 in the control group，respectively，without significant difference (P>0.05).Conclusion　ROP children have smaller or undefined FAZ，the thickened CFT and the increased SCP density，and the BCVA is not affected by the FAZ area and CFT in this study.

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备注/Memo

备注/Memo:
广州市科技局基金项目（编号：11C33150706）；广东省自然科学基金（编号：S20130400125 62）
更新日期/Last Update: 2018-04-02