[1]仲妍,车慧欣.光学相干断层扫描血管成像（OCTA）在原发性青光眼患者中的检测价值[J].眼科新进展,2018,38(4):352-356.[doi:10.13389/j.cnki.rao.2018.0082]
　ZHONG Yan,CHE Hui-Xin.Detective values of optical coherence tomography angiographyfor primary glaucoma[J].Recent Advances in Ophthalmology,2018,38(4):352-356.[doi:10.13389/j.cnki.rao.2018.0082]
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光学相干断层扫描血管成像（OCTA）在原发性青光眼患者中的检测价值/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
38卷
期数:
2018年4期
页码:
352-356
栏目:
应用研究
出版日期:
2018-04-05

文章信息/Info

Title:
Detective values of optical coherence tomography angiographyfor primary glaucoma
作者:
仲妍; 车慧欣
121000　辽宁省锦州市，锦州医科大学
Author(s):
ZHONG Yan; CHE Hui-Xin
Jinzhou Medical University，Jinzhou 121000，Liaoning Province，China
关键词:
光学相干断层扫描血管成像; 原发性青光眼; 血管密度; 视网膜神经节细胞
Keywords:
optical coherence tomography angiography; primary glaucoma; vessel density; retinal ganglion cells
分类号:
R775
DOI:
10.13389/j.cnki.rao.2018.0082
文献标志码:
A
摘要:
目的　探讨光学相干断层扫描血管成像（optical coherence tomography，OCTA）在原发性青光眼中的检测价值。方法　选取原发性青光眼患者70例（116眼）为试验组，正常人20例（36眼）为对照组。比较OCTA测得的黄斑区血管密度、黄斑视网膜神经节细胞（retinal ganglion cell，RGC）层厚度、黄斑全层厚度及视盘区视网膜色素上皮（retinal pigment epithelium，RPE）开口距离在2组受试眼中的变化，并对各参数与视野平均缺损（mean deviation，MD）值进行相关性分析。结果　对照组与试验组的上方黄斑全层厚度、下方黄斑全层厚度、黄斑RGC厚度和黄斑区血管密度比较，组间差异均有统计学意义（均为P＜0.05）。视盘区RPE开口距离在对照组、试验组间差异无统计学意义（F=2.646，P=0.051 3）。黄斑区血管密度、黄斑RGC厚度、黄斑全层厚度与视野MD值均呈线性正相关（均为r＞0.5、P＜0.01）。黄斑区血管密度、黄斑RGC厚度、黄斑全层厚度对青光眼诊断ROC曲线的曲线下面积值均大于0.7。结论　OCTA测得的黄斑区血管密度、黄斑RGC厚度、黄斑全层厚度与视野MD值均呈线性正相关，均具有较高的青光眼诊断效能。
Abstract:
Objective　To investigate the diagnostic significance of optical coherence tomography angiography (OCTA) in the detection of primary glaucoma.Methods　Totally 70 patients (116 eyes) of primary glaucoma were selected as the experimental group and 20 normal subjects (36 eyes) as the control group.The changes in macular vessel density，macular retinal ganglion cell(RGC) thickness，macular thickness，and optic disc retinal pigment epithelium(RPE) opening distance were measured by OCTA，and the correlation between the parameters and the mean deviation (MD) of visual field.Results　When compared with the control group，the upper macular thickness，inferior macular thickness，macular RGC thickness and macular vessel density were reduced in the experimental group(all P<0.05).There was no significant difference in optic disc RPE opening distance between the control group and the experimental group(F=2.646，P=0.051 3).Linear positive correlations were found between macular thickness，macular RGC thickness，macular vessel density and MD(all r>0.5，P＜0.01).The area under the curve of the diagnostic ROC curve of the macular vessel density，macular RGC thickness and macular thickness for glaucoma were all greater than 0.7.Conclusion　There are linear positive correlations between macular thickness，macular RGC thickness，macular vessel density and MD.The parameters have a high diagnostic ability for the primary glaucoma.OCTA is a valuable technique for detecting glaucoma.

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备注/Memo

备注/Memo:
辽宁省自然科学基金资助（编号：2014022022）；2015年辽宁省大学生创新训练计划项目（编号：201510160000042）
更新日期/Last Update: 2018-04-02