[1]郑玲,冯光强.小梁细胞表达的miRNA研究新进展[J].眼科新进展,2014,34(11):1094-1096.[doi:10.13389/j.cnki.rao.2014.0304]
　ZHENG Ling,FENG Guang-Qiang.Research advances in miRNA in human trabecular meshwork cells[J].Recent Advances in Ophthalmology,2014,34(11):1094-1096.[doi:10.13389/j.cnki.rao.2014.0304]
点击复制

小梁细胞表达的miRNA研究新进展
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
34卷
期数:
2014年11期
页码:
1094-1096
栏目:
文献综述
出版日期:
2014-11-05

文章信息/Info

Title:
Research advances in miRNA in human trabecular meshwork cells
作者:
郑玲; 冯光强
510000　广东省广州市，广州医科大学，广州市妇女儿童医疗中心眼科
Author(s):
ZHENG Ling; FENG Guang-Qiang
关键词:
miRNA; 人小梁细胞; 靶基因; 青光眼
Keywords:
miRNA ;  human trabecular meshwork cells ;  target gene ;  glaucoma
DOI:
10.13389/j.cnki.rao.2014.0304
文献标志码:
A
摘要:
ｍｉＲＮＡ是一种长约２２个核苷酸的非编码蛋白质的单链小ＲＮＡ，其对基因的调控主要是在转录后和翻译水平来调节基因表达。目前发现与眼部相关的ｍｉＲＮＡ已达上百种，有不少研究旨在探索ｍｉＲＮＡ在人小梁细胞上的表达及其与靶基因之间的调控机制，为进一步阐述青光眼的发病机制及其诊断、治疗提供更好的理论依据。近年来，有关ｍｉＲＮＡ与眼部组织发育、眼部疾病关系的探讨已成为眼科领域研究热点之一。本文就小梁细胞表达的ｍｉＲＮＡ研究最新进展作一综述。
Abstract:
MiRNA, a non-coding proteins of single small RNA of 22-nucleotideslong,controls the expression of gene mainly in the transcription and translation level. Recently,hundreds of miRNA kinds have been found concerrung about ocular tissues. and many foreign researches are aimed to explore miRNA in the expression of human trabecular meshwork cells. the regulatory mechanism between nuRNA and its target genes, which provide a better theoretical basis for the abnormal trabecular meshwork that leads to glaucoma in pathogenesis , diagnosis and treatment. This article reviews the research advances in miRNA in human trabecular meshwork cells.

相似文献/References:

[1]吕洋,侯慧媛,王雨生. miRNA在脉络膜新生血管发生发展中的作用研究进展[J].眼科新进展,2015,35(3):283.[doi:10.13389/j.cnki.rao.2015.0076]
　LV Yang,HOU Hui-Yuan,WANG Yu-Sheng. Research advances in role of miRNA in development of choroidal neovascularization[J].Recent Advances in Ophthalmology,2015,35(11):283.[doi:10.13389/j.cnki.rao.2015.0076]
[2]孙园园,郭大东,毕宏生.MicroRNA在葡萄膜炎发病过程中的调控作用研究进展[J].眼科新进展,2016,36(11):1082.[doi:10.13389/j.cnki.rao.2016.0289]
　SUN Yuan-Yuan,GUO Da-Dong,BI Hong-Sheng.Recent advances in regulatory effects of microRNA in pathogenesis of uveitis[J].Recent Advances in Ophthalmology,2016,36(11):1082.[doi:10.13389/j.cnki.rao.2016.0289]
[3]余曦,田敏,何薇,等.叔丁基对苯二酚对糖尿病大鼠视网膜的保护作用及其机制研究[J].眼科新进展,2018,38(8):719.[doi:10.13389/j.cnki.rao.2018.0169]
　YU Xi,TIAN Min,HE Wei,et al.Protective effects of tert-butylhydroquinone on the retina of diabetic rats and its mechanisms[J].Recent Advances in Ophthalmology,2018,38(11):719.[doi:10.13389/j.cnki.rao.2018.0169]
[4]刘阳,兰长骏,廖萱.近视的表观遗传学研究[J].眼科新进展,2018,38(10):909.[doi:10.13389/j.cnki.rao.2018.0215]
　LIU Yang,LAN Chang-Jun,LIAO Xuan.Review progress on epigenetics of myopia[J].Recent Advances in Ophthalmology,2018,38(11):909.[doi:10.13389/j.cnki.rao.2018.0215]
[5]朱美江,任成达,蔡雯婷,等.外周血液中miRNA表达与老年性黄斑变性相关性研究[J].眼科新进展,2019,39(7):677.[doi:10.13389/j.cnki.rao.2019.0156]
　ZHU Mei-Jiang,REN Cheng-Da,CAI Wen-Ting,et al.Correlation between the expression of circulating miRNAs and age-related macular degeneration[J].Recent Advances in Ophthalmology,2019,39(11):677.[doi:10.13389/j.cnki.rao.2019.0156]
[6]张文怡,吴安然,张国伟,等.miRNA调节自噬在眼科疾病中的应用[J].眼科新进展,2022,42(8):649.[doi:10.13389/j.cnki.rao.2022.0133]
　ZHANG Wenyi,WU Anran,ZHANG Guowei,et al.Role of microRNA-regulated autophagy in ophthalmic diseases[J].Recent Advances in Ophthalmology,2022,42(11):649.[doi:10.13389/j.cnki.rao.2022.0133]

更新日期/Last Update: 2014-11-11