[1]刘阳,兰长骏,廖萱.近视的表观遗传学研究[J].眼科新进展,2018,38(10):909-912.[doi:10.13389/j.cnki.rao.2018.0215]
　LIU Yang,LAN Chang-Jun,LIAO Xuan.Review progress on epigenetics of myopia[J].Recent Advances in Ophthalmology,2018,38(10):909-912.[doi:10.13389/j.cnki.rao.2018.0215]
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近视的表观遗传学研究/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
38卷
期数:
2018年10期
页码:
909-912
栏目:
近视专题
出版日期:
2018-10-05

文章信息/Info

Title:
Review progress on epigenetics of myopia
作者:
刘阳; 兰长骏; 廖萱
637000　四川省南充市，川北医学院附属医院眼科，川北医学院眼视光学系
Author(s):
LIU Yang; LAN Chang-Jun; LIAO Xuan
Department of Ophthalmology，Affiliated Hospital of North Sichuan Medical College；Department of Ophthalmology & Optometry，North Sichuan Medical College，Nanchong 637000，Sichuan Province，China
关键词:
表观遗传学; 近视; DNA甲基化; miRNA; 组蛋白修饰
Keywords:
epigenetics; myopia; DNA methylation; miRNA; histone modification
分类号:
R778.1
DOI:
10.13389/j.cnki.rao.2018.0215
文献标志码:
A
摘要:
近视是全球范围内最常见的一类屈光不正，在过去几十年间，近视发病率逐年上升而发病年龄趋于提前，已成为重大的公共卫生问题。近视被认为是由遗传因素和环境因素以及基因-环境交互作用影响的多因素复杂疾病，尽管大量的实验研究对近视的发生发展机制进行了探索，但其确切病因及病理机制仍未阐明。表观遗传学作为目前生物医学研究的热点，加深了人们对近视发生发展机制的认识。本文就近年来近视表观遗传方面的研究进行综述。
Abstract:
Myopia is the most common type of refractive error in the world.In the past few decades，the incidence of myopia has increased year by year and the age of onset has been younger than before，which has become a major public health problem.Myopia is considered as a complex disease caused by genetic and environmental factors and gene-environment interaction.The exact etiology and pathogenesis of myopia has not been elucidated，although a lot of experimental researches have explored it.Epigenetics，as a hotspot in biomedical research，has deepened our understanding，and this present article will give a review on the recent progress of the epigenetics of myopia.

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备注/Memo

备注/Memo:
四川省卫计委科研项目（编号：17PJ529）；南充市市校科技战略合作项目（编号：NSMC20170450）；川北医学院博士科研基金项目（编号：CBY14-QD-05）；四川省教育厅自然科学重点项目（编号：14ZA0183）
更新日期/Last Update: 2018-09-28