[1]张媛媛,李筱荣,邵彦.糖尿病视网膜病变“代谢记忆”与线粒体功能相关性研究进展[J].眼科新进展,2023,43(12):1005-1008.[doi:10.13389/j.cnki.rao.2023.0200]
　ZHANG Yuanyuan,LI Xiaorong,SHAO Yan.Research progress on the correlation between metabolic memory and mitochondrial function in diabetic retinopathy[J].Recent Advances in Ophthalmology,2023,43(12):1005-1008.[doi:10.13389/j.cnki.rao.2023.0200]
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糖尿病视网膜病变“代谢记忆”与线粒体功能相关性研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
43卷
期数:
2023年12期
页码:
1005-1008
栏目:
文献综述
出版日期:
2023-12-05

文章信息/Info

Title:
Research progress on the correlation between metabolic memory and mitochondrial function in diabetic retinopathy
作者:
张媛媛; 李筱荣; 邵彦
300384　天津市，天津医科大学眼科医院、眼视光学院、眼科研究所，国家眼耳鼻喉疾病临床医学研究中心天津市分中心，天津市视网膜功能与疾病重点实验室
Author(s):
ZHANG Yuanyuan; LI Xiaorong; SHAO Yan
Tianjin Key Laboratory of Retinal Functions and Diseases,Tianjin Branch of National Clinical Research Center for Ocular Disease,Eye Institute and School of Optometry,Tianjin Medical University Eye Hospital,Tianjin 300384,China
关键词:
线粒体; 代谢记忆; 糖尿病视网膜病变; 氧化应激; 糖尿病
Keywords:
mitochondria;  metabolic memory;  diabetic retinopathy;  oxidative stress;  diabetes
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2023.0200
文献标志码:
A
摘要:
糖尿病视网膜病变（DR）是由糖尿病导致的严重致盲性眼病。多项研究表明糖尿病患者体内存在“代谢记忆”现象，但其相关机制目前尚不清楚。在DR的发病和进展过程中，高血糖环境下氧化应激使DR患者视网膜细胞中线粒体DNA（mtDNA）拷贝数异常发生突变，其修复系统同时遭到破坏并形成恶性循环，造成体内活性氧（ROS）过量生成、氧化还原稳态破坏和细胞凋亡等现象发生。由于mtDNA可以进行独立复制并遗传给下一代，同时表观遗传学修饰也会影响与DR发病机制相关基因的调节。在DR发生发展过程中，明确线粒体损伤和“代谢记忆”现象的发生机制对DR的预防和治疗具有重要意义，线粒体转移技术的出现将有望打破“代谢记忆”现象，为此类疾病的治疗开辟新的途径。本文就其相关研究及发展做一综述。
Abstract:
Diabetic retinopathy (DR) is a severe blinding eye disease caused by diabetes. A number of studies have shown that there is a phenomenon of “metabolic memory” in diabetic patients, but its mechanism is still unclear. In the occurrence and progression of DR, oxidative stress in a high-glucose environment causes abnormal mutations of mitochondrial DNA (mtDNA) copy number in retinal cells, and its repair system is destroyed at the same time and forms a vicious circle, resulting in excessive production of reactive oxygen, destruction of redox homeostasis and apoptosis. The mtDNA can be independently replicated and passed on to the next generation, and epigenetic modification can also affect the regulation of genes related to the pathogenesis of DR. In the occurrence and development of DR, it is of great significance to clarify the mechanism of mitochondrial damage and “metabolic memory” for the prevention and treatment of DR. The emergence of mitochondrial transfer technology is expected to break the “metabolic memory” phenomenon and open up new avenues for treating such diseases. This article gives a review of the related research and development.

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备注/Memo

备注/Memo:
国家自然科学基金资助（编号：81900891）
更新日期/Last Update: 2023-12-05