[1]王紫郦,魏婷婷,谢田华,等.线粒体功能紊乱在糖尿病视网膜病变中作用的研究进展[J].眼科新进展,2022,42(12):999-1003.[doi:10.13389/j.cnki.rao.2022.0204]
　WANG Zili,WEI Tingting,XIE Tianhua,et al.Research progress on the role of mitochondrial dysfunction in diabetic retinopathy[J].Recent Advances in Ophthalmology,2022,42(12):999-1003.[doi:10.13389/j.cnki.rao.2022.0204]
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线粒体功能紊乱在糖尿病视网膜病变中作用的研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
42卷
期数:
2022年12期
页码:
999-1003
栏目:
文献综述
出版日期:
2022-12-05

文章信息/Info

Title:
Research progress on the role of mitochondrial dysfunction in diabetic retinopathy
作者:
王紫郦; 魏婷婷; 谢田华; 蔡季平; 姚勇
214023　江苏省无锡市，南京医科大学附属无锡人民医院眼科（王紫郦，谢田华，蔡季平，姚勇）；214023　江苏省无锡市，南京医科大学附属无锡人民医院临床研究中心（魏婷婷）
Author(s):
WANG Zili1; WEI Tingting2; XIE Tianhua1; CAI Jiping1; YAO Yong1
1.Department of Ophthalmology,the Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi 214023,Jiangsu Province,China
2.Center of Clinical Research,the Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi 214023,Jiangsu Province,China
关键词:
糖尿病视网膜病变; 线粒体; 线粒体功能紊乱。
Keywords:
diabetic retinopathy;  mitochondria;  mitochondrial dysfunction
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2022.0204
文献标志码:
A
摘要:
糖尿病视网膜病变 (DR) 作为最常见的视网膜血管病变，是40岁以上人群主要致盲性眼病之一。抗血管内皮生长因子 (VEGF) 疗法在 DR 患者中有显著的临床效果，但需要长期不间断治疗，且大多数患者未能实现具有临床意义的视力改善。因此，寻找新的治疗靶点和方法迫在眉睫。线粒体是真核细胞中负责产生化学能量并协调细胞信号的细胞器，对维持细胞结构和功能起着关键作用。越来越多的研究表明，线粒体参与了 DR 病理生理过程。本文就线粒体功能紊乱在 DR 发病过程中的作用展开综述，为 DR 的发病机制和治疗方案提供新的思路。
Abstract:
Diabetic retinopathy (DR), the most common retinal vasculopathy, is one of the primary causes of blindness in people over 40. The anti-vascular endothelial growth factor therapy has shown significant clinical effects in DR patients, but it needs long-term uninterrupted treatment with no clinically significant vision improvement in most patients. Therefore, there is an urgent need to find new therapeutic targets and strategies. Mitochondria are cellular organelles responsible for the generation of chemical energy and coordination of related cell signals in eukaryotic cells. They play a crucial role in maintaining cell structure and function. A growing body of studies demonstrates that mitochondria are involved in the pathogenesis of DR. This review focuses on the role of mitochondrial dysfunction in the pathogenesis of DR and provides novel ideas for the pathogenesis and treatment of DR.

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备注/Memo

备注/Memo:
江苏省自然科学基金（编号：BK20200163）；2020年度“太湖人才计划”顶尖医学专家团队(编号：2020-THRCTD-1)；江苏省科教强卫重点学科项目(编号：ZDXKC2016008)
更新日期/Last Update: 2022-12-05