[1]郑雨薇,蒋正轩,李恒,等.2型糖尿病患者干眼相关指标分析[J].眼科新进展,2022,42(11):874-878.[doi:10.13389/j.cnki.rao.2022.0180]
　ZHENG Yuwei,JIANG Zhengxuan,LI Heng,et al.Analysis of dry eye related factors in type 2 diabetic patients[J].Recent Advances in Ophthalmology,2022,42(11):874-878.[doi:10.13389/j.cnki.rao.2022.0180]
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2型糖尿病患者干眼相关指标分析/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
42卷
期数:
2022年11期
页码:
874-878
栏目:
应用研究
出版日期:
2022-11-05

文章信息/Info

Title:
Analysis of dry eye related factors in type 2 diabetic patients
作者:
郑雨薇; 蒋正轩; 李恒; 万茜茜; 郭斌; 张鹏宇; 陶黎明
233001　安徽省合肥市，安徽医科大学第二附属医院眼科（郑雨薇，蒋正轩，万茜茜，张鹏宇，陶黎明）；300000　天津市，武警后勤学院 （李恒）；233001　安徽省合肥市，中国科学技术大学附属第一医院（郭斌）
Author(s):
ZHENG Yuwei1; JIANG Zhengxuan1; LI Heng2; WAN Qianqian1; GUO Bin3; ZHANG Pengyu1; TAO Liming1
1.Department of Ophthalmology,the Second Affiliated Hospital of Anhui Medical University,Hefei 233001,Anhui Province,China
2.Logistics University of People’s Armed Police Force,Tianjin 300000,China
3.The First Affiliated Hospital of University of Science and Technology of China,Hefei 233001,Anhui Province,China
关键词:
糖尿病; 干眼; 睑板腺; 黄斑水肿; 糖尿病视网膜病变
Keywords:
diabetes mellitus;  dry eye;  meibomian gland;  macular edema;  diabetic retinopathy
分类号:
R771.3
DOI:
10.13389/j.cnki.rao.2022.0180
文献标志码:
A
摘要:
目的　观察2型糖尿病患者的眼表情况，探讨可能引起糖尿病患者干眼的影响因素。方法　纳入2型糖尿病患者110例110眼、正常受试者46例46眼。所有受试者均进行OSDI主观评分、Keratogragh 5M检查。所有糖尿病患者记录病程、糖化血红蛋白（HbA1c），并行眼底镜及OCT检查评估眼底病变情况，根据有无糖尿病视网膜病变、有无黄斑水肿、HbA1c水平、糖尿病病程长短分组，分析不同分组条件下非侵入性泪膜破裂时间(NI-BUTav)、睑板腺缺失评分、眼红指数、泪河高度及OSDI评分的改变情况。结果　与正常受试者相比，糖尿病患者NI-BUTav降低，OSDI评分、睑板腺缺失评分升高，差异均有统计学意义（均为P<0.05）。HbA1c≥7%的糖尿病患者OSDI评分高于 HbA1c<7%的糖尿病患者，差异有统计学意义（P=0.04）。有黄斑水肿的糖尿病患者的OSDI 评分、眼红指数均大于无黄斑水肿的患者，差异均有统计学意义（均为P<0.05）。糖尿病病程≥10年的患者泪河高度较病程<10年者显著降低，差异有统计学意义（P=0.00）。结论　2型糖尿病患者泪膜质量下降，干眼的主观不适症状更为明显。血糖控制较差或合并黄斑水肿的2型糖尿病患者主观不适较为严重，糖尿病病程较长者基础泪液分泌水平下降。
Abstract:
Objective　To explore the possible influencing factors of diabetic dry eye by evaluating the ocular surface of type 2 diabetic patients. Methods　A total of 110 type 2 diabetic patients (110 eyes) and 46 healthy individuals (46 eyes) were recruited. All patients underwent Ocular Surface Disease Index (OSDI) scoring and Keratogragh 5M examination. The duration of diabetes mellitus (DM) and glycosylated hemoglobin (HbA1c) level of all diabetic patients were recorded. Ophthalmoscopy and optical coherence tomography were performed to evaluate the fundus lesions. The patients were divided into different groups according to diabetic retinopathy, macular edema, HbA1c level, and DM duration, and their average non-invasive break-up time (NI-BUTav), meibomian gland deficiency score, ocular redness, tear meniscus height, and OSDI score were analyzed. Results　Compared with the normal controls, the NI-BUTav decreased, while the OSDI score and meibomian gland deficiency score increased in diabetic patients (all P<0.05). The OSDI score in the HbA1c≥7% group was significantly higher than that in the HbA1c<7% group (P=0.04). The OSDI score and ocular redness of patients with macular edema were higher than those without macular edema (both P<0.05). The tear meniscus height in the DM duration≥10 years group declined remarkably compared with the DM duration<10 years group (P=0.00). Conclusion　Compared with healthy people, type 2 diabetic patients’ tear film deteriorates, and their discomforts caused by dry eye are more obvious. Especially the type 2 diabetic patients with poor blood glucose control or macular edema have more serious dry eye discomforts. The basal tear secretion decreases in patients with a longer DM duration.

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备注/Memo

备注/Memo:
国家自然科学基金（编号：82070986）
更新日期/Last Update: 2022-11-05