[1]朱跃弟,姚琨,姚蕊莲.中老年人血清25-羟基维生素D水平与老年性白内障发生的相关性分析[J].眼科新进展,2019,39(7):686-689.[doi:10.13389/j.cnki.rao.2019.0158]
　ZHU Yue-Di,YAO Kun,YAO Rui-Lian.Relationship between serum 25-hydroxyvitamin D level and senile cataract (SC) in middle-aged and aged population[J].Recent Advances in Ophthalmology,2019,39(7):686-689.[doi:10.13389/j.cnki.rao.2019.0158]
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中老年人血清25-羟基维生素D水平与老年性白内障发生的相关性分析/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
39卷
期数:
2019年7期
页码:
686-689
栏目:
应用研究
出版日期:
2019-07-05

文章信息/Info

Title:
Relationship between serum 25-hydroxyvitamin D level and senile cataract (SC) in middle-aged and aged population
作者:
朱跃弟; 姚琨; 姚蕊莲
044000　山西省运城市，运城护理职业学院临床学科部五官教研室（朱跃弟，姚琨）；044000　山西省运城市，运城市眼科医院眼科（姚蕊莲）
Author(s):
ZHU Yue-Di; YAO Kun; YAO Rui-Lian
Department of ENT Teaching and Research Section of Clinical Medicine,Yuncheng Vocational Nursing College (ZHU Yue-Di,YAO Kun),Yuncheng 044000,Shanxi Province,China;Department of Ophthalmology,Yuncheng Eye Hospital (YAO Rui-Lian),Yuncheng 044000,Shanxi Province,China
关键词:
25-羟基维生素D; 老年性白内障; 相关性分析; 影响因素
Keywords:
25-hydroxyvitamin D; senile cataract; correlation analysis; influence factors
分类号:
R776.1
DOI:
10.13389/j.cnki.rao.2019.0158
文献标志码:
A
摘要:
目的　探讨中老年人血清25-羟基维生素D［25-(OH)-D］水平与老年性白内障（senile cataract，SC）发生的相关性。方法　采用横断面调查，选取2017年5月至2018年5月在运城市眼科医院门诊体检的400例45岁以上中老年人为研究对象。采用自制调查表收集其SC患病情况等临床资料，以Cobas 6000 e601型电化学发光仪（瑞士罗氏公司）测定25-(OH)-D水平。通过Spearman或Pearson相关性分析血清25-(OH)-D水平与临床资料或临床指标的相关性，Logistic回归分析SC发生的相关影响因素。结果　相关性分析显示：血清25-(OH)-D水平与男性、户外光暴露时间均呈正相关性（均为P<0.05），与年龄、吸烟和饮酒均呈负相关性（均为P<0.05）。Logistic回归分析表明，与SC发生相关的影响因素包括性别、年龄、高血压、糖尿病、低密度脂蛋白水平、长时间太阳光暴露和血清25-(OH)-D水平（均为P<0.05）；而血清25-(OH)-D水平与SC发生呈负相关（OR=0.77，95%CI：0.61-0.89，P<0.05）。结论　长时间太阳光暴露和25-(OH)-D缺乏可能与SC的发生有关，适当的阳光照射或补充维生素D有助于预防和改善SC的发生和进展。
Abstract:
Objective　To study the relationship between serum 25-hydroxyvitamin D ［25-(OH)-D］ level and senile cataract (SC) in middle-aged and aged population.Methods　The cross-sectional study was undertaken on 400 middle-aged and aged outpatients (age >45 years) participated in the physical examination in Yuncheng Eye Hospital during May,2017 to May,2018.The clinical information,such as the status of SC,was collected by self-designed questionnaires.Serum 25-(OH)-D level was detected by Roche Cobas e601 automatic electrochemical luminescence immunoassay analyzer.Spearman or Pearson correlation analysis was used to analyze the relationship between serum 25-(OH)-D and clinical date or clinical indexes.The influence factors associated with SC were analyzed by Logistic regression analysis.Results　Correlation analysis showed that the serum 25-(OH)-D level was positively correlated with male,and long sun exposure time (both P<0.05),and negatively correlated with age,smoke status and alcohol consumption (all P<0.05).Logistic regression analysis showed the influence factors associated with SC including gender,age,hypertension,diabetes,low density lipoprotein level,long sun exposure time and serum 25-(OH)-D level (all P<0.05),and the inverse correlation between serum 25-(OH)-D level and SC (OR=0.77,95%CI:0.61-0.89,P<0.05).Conclusion　The long sun exposure time and 25-(OH)-D deficiency may be relevant to the occurrence of SC.Appropriate sun exposure or vitamin D supplements may help to prevent the development and progression of SC.

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更新日期/Last Update: 2019-07-01