[1]王文颜,张学东.NLRP3炎症小体在糖尿病视网膜病变中的作用[J].眼科新进展,2018,38(6):587-591.[doi:10.13389/j.cnki.rao.2018.0139]
　WANG Wen-Yan,ZHANG Xue-Dong.The role and research progress of NLRP3 inflammasome in diabetic retinopathy[J].Recent Advances in Ophthalmology,2018,38(6):587-591.[doi:10.13389/j.cnki.rao.2018.0139]
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NLRP3炎症小体在糖尿病视网膜病变中的作用/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
38卷
期数:
2018年6期
页码:
587-591
栏目:
文献综述
出版日期:
2018-06-05

文章信息/Info

Title:
The role and research progress of NLRP3 inflammasome in diabetic retinopathy
作者:
王文颜; 张学东
400010　重庆市，重庆医科大学附属第一医院眼科 重庆市眼科研究所 眼科学重庆市市级重点实验室
Author(s):
WANG Wen-Yan; ZHANG Xue-Dong
Ophthalmology，the First Affiliated Hospital of Chongqing Medical University，Chongqing Key Laboratory of Ophthalmology，Chongqing Eye Institute，Chongqing 400010,China
关键词:
糖尿病视网膜病变; NLRP3炎症小体; 治疗靶点
Keywords:
diabetic retinopathy;  NLRP3 inflammasome; targets for therapy
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2018.0139
文献标志码:
A
摘要:
糖尿病视网膜病变（diabetic retinopathy，DR）是糖尿病导致的严重微血管并发症之一。目前，对于DR确切的发病机制仍无定论。近期研究表明，炎症与自身免疫反应在DR的发生发展中起着重要作用。核苷酸结合寡聚化结构域样受体蛋白3（nucleotide-binding domain and leucine-rich repeat receptor containing a pyrin domain 3，NLRP3）炎症小体能触发各种炎症反应，并在多种慢性炎症性疾病中发挥重要作用。现已有不少研究证实NLRP3炎症小体通过参与多条通路在DR中发挥促炎作用，提示通过抑制NLPR3炎症小体或者其参与的通路或许可成为DR治疗新靶点。本文就NLRP3炎症小体在DR发病中的作用作一综述。
Abstract:
Diabetic retinopathy （DR） is one of the severe microvascular complications caused by diabetes，and the precise pathogenesis of DR is still unsettled now.Recent studies have shown that inflammation and autoimmune responses play important roles in the development of DR.Nucleotide-binding domain and leucine-rich repeat receptor containing a pyrin domain 3 （NLRP3） inflammasome can trigger a variety of inflammatory responses and involves in various chronic inflammatory diseases.At present，a large number of studies have confirmed that NLRP3 inflammasome promotes inflammatory responses in DR through multiple pathways，which have suggested that inhibition of NLPR3 inflammasome or its involved pathways may have therapeutic effects on DR，and the role of NLRP3 inflammasome in DR will be reviewed in this article.

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备注/Memo

备注/Memo:
国家自然科学基金资助（编号：81371843）
更新日期/Last Update: 2018-07-10