[1]李亭亭,刘芳,王方.年龄相关性黄斑变性与阿尔茨海默病的相关性[J].眼科新进展,2017,37(12):1189-1192.[doi:10.13389/j.cnki.rao.2017.0300]
　LI Ting-Ting,LIU Fang,WANG Fang.Research progress on the relationship between age-related macular degeneration and Alzheimer’s disease[J].Recent Advances in Ophthalmology,2017,37(12):1189-1192.[doi:10.13389/j.cnki.rao.2017.0300]
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年龄相关性黄斑变性与阿尔茨海默病的相关性/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
37卷
期数:
2017年12期
页码:
1189-1192
栏目:
文献综述
出版日期:
2017-12-05

文章信息/Info

Title:
Research progress on the relationship between age-related macular degeneration and Alzheimer’s disease
作者:
李亭亭; 刘芳; 王方
200072　上海市，南京医科大学上海十院临床医学院眼科（李亭亭，刘芳）；200072　上海市，同济大学附属第十人民医院眼科（刘芳，王方）
Author(s):
LI Ting-Ting; LIU Fang; WANG Fang
Department of Ophthalmology，Clinical Medical College of Shanghai Tenth People’s Hospital of Nanjing Medical University（LI Ting-Ting，LIU Fang），Shanghai 200072，China；Department of Ophthalmology，Shanghai Tenth People’s Hospital Affiliated to Tongji University（LIU Fang,WANG Fang），Shanghai 200072，China
关键词:
年龄相关性黄斑变性; 阿尔茨海默病; β-淀粉样蛋白; 玻璃膜疣; 光学相干断层扫描
Keywords:
age-related macular degeneration; Alzheimer’s disease; β-amyloid; drusen; optical coherence tomography
分类号:
R774.5
DOI:
10.13389/j.cnki.rao.2017.0300
文献标志码:
A
摘要:
年龄相关性黄斑变性（age-related macular degeneration，AMD） 又称老年性黄斑变性，是全球老年人视力丧失最主要的原因，目前发病机制尚不完全清楚。阿尔茨海默病（Alzheimer’s disease，AD），是一种年龄相关的慢性神经退行性疾病，以进行性认知功能障碍为主要临床表现，在老年人中的发病率逐年升高。研究发现AMD患者会出现轻度认知功能障碍，玻璃膜疣的成分含有β-淀粉样蛋白；而AD患者不仅存在认知功能障碍，且眼部结构及功能也会出现异常，包括视力视野损伤、视网膜结构改变，神经纤维层厚度变薄等，推测二者之间可能存在密切联系。本综述通过对AMD和AD在检查方法、发病机制及流行病学上的相关性进行论述，探讨两种疾病的相关性，目的是为疾病诊断提供依据。
Abstract:
Age-related macular degeneration （AMD），also known as age-related macular degeneration，is the leading cause of vision loss in the elderly worldwide，but its pathogenesis is not yet fully understood.Alzheimer’s disease （AD），an age-related chronic neurodegenerative disease with progressive cognitive impairment as the main clinical manifestation，has been increasing year by year in the elderly.Studies have found that mild cognitive impairment occurs in patients with AMD，and the composition of drusen contains β-amyloid；however，patients with AD have not only cognitive dysfunction，but also ocular structure and function abnormalities，including visual field damage，changes in retinal structure，thinning of nerve fiber layer thickness，so it has been speculated that there may be close relationship between AMD and AD.Therefore，in this review，the association of examination，pathogenesis and incidence of AD and AMD will be discussed for providing a basis for disease diagnosis.

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备注/Memo

备注/Memo:
上海市卫生和计划生育委员会科研课题基金项目（编号：201540046）
更新日期/Last Update: 2017-12-08