[1]王瑛,王剑,樊宁,等.垂体腺瘤视野表现的特征[J].眼科新进展,2016,36(10):963-966.[doi:10.13389/j.cnki.rao.2016.0258]
　WANG Ying,WANG Jian,FAN Ning,et al.Feature analysis of visual field defects in pituitary adenoma[J].Recent Advances in Ophthalmology,2016,36(10):963-966.[doi:10.13389/j.cnki.rao.2016.0258]
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垂体腺瘤视野表现的特征
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年10期
页码:
963-966
栏目:
应用研究
出版日期:
2016-10-05

文章信息/Info

Title:
Feature analysis of visual field defects in pituitary adenoma
作者:
王瑛; 王剑; 樊宁; 刘旭阳
518000　广东省深圳市，深圳大学光电工程学院，光电子器件与系统（教育部/广东省）重点实验室（王瑛）；100000　北京市，北京天坛医院眼科（王剑）；518000　广东省深圳市，暨南大学附属深圳市眼科医院、深圳眼科学重点实验室、深圳大学眼视光学院（樊宁，刘旭阳）
Author(s):
WANG Ying; WANG Jian ; FAN Ning ;  LIU Xu-Yang
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelearonic Engineering, Shenzhen University(WANG Ying), Shenzhen 518000, Guangdong Province. China; Department of Ophthalmology, Tiantan Hospital( WANG Jian ),Beijing 100000,China; Shenzhen Eye Hospital, Jinan University, Shenzhen Key Laboratory of Ophthalmology, Optometry College of Shenzhen University(FAN Ning, LIU Xu-Yang ), Shenzhen 518000, Guangdong Province. China
关键词:
垂体腺瘤; 视野; 光学相干断层扫描; 视交叉
Keywords:
pituitary adenoma;  visual field;  optical coherence tomography;  optic chiasma
分类号:
Ｒ７７１.３
DOI:
10.13389/j.cnki.rao.2016.0258
文献标志码:
A
摘要:
目的　探讨垂体腺瘤视野表现特征。方法　收集于神经外科经病理确诊为垂体腺瘤的３７１例患者的视野及光学相干断层扫描（ｏｐｔｉｃａｌｃｏｈｅｒｅｎｃｅｔｏｍｏｇｒａｐｈｙ，ＯＣＴ）资料。将垂体腺瘤患者根据视野缺损改变分为颞侧象限性视野缺损组、颞侧垂直性偏盲组和管状视野组。分析视野缺损形态特征，通过线性相关分析及方差分析对视野缺损形态、视野平均光敏感度（ｍｅａｎｓｅｎｓｉｔｉｖｉｔｙ，ＭＳ）等指标与ＯＣＴ测量视网膜神经纤维层（ｒｅｔｉｎａｌｎｅｒｖｅｆｉｂｅｒｌａｙｅｒ，ＲＮＦＬ）厚度、肿瘤体积之间的关系进行分析。结果　颞侧象限性视野缺损组、颞侧垂直性偏盲组和管状视野组三组间ＲＮＦＬ厚度、ＭＳ值差异均具有统计学意义（均为Ｐ＝０．００），垂体腺瘤体积差异无统计学意义（χ２ ＝０．５８，Ｐ＝０．７５）。颞侧垂直性偏盲组与管状视野组中，ＭＳ和对应眼鼻侧ＲＮＦＬ厚度有直线关系（Ｒ２ ＝０．１８６，ｔ＝４．７６，Ｐ＝０．００；Ｒ２＝０．１４６，ｔ＝２．６５，Ｐ＝０．０１），ＲＮＦＬ厚度、ＭＳ与肿瘤体积均无直线关系（均为Ｐ＞０．０５）。结论　视野缺损类型与垂体腺瘤侵犯视交叉的位置有关。相应受累眼视野缺损程度与视网膜ＲＮＦＬ厚度、ＭＳ值有一致性。受累眼的ＭＳ值变化与ＲＮＦＬ厚度有一致性。视野缺损改变、ＲＮＦＬ厚度、ＭＳ与肿瘤体积单一因素无关。
Abstract:
Objective To analyze visual field defects in pituitary adenoma. Methods A total of 371 patients with pituitary adenoma were enrolled in the neurosurgery department , the features of visual field ( VF) and OCT were collected. According to the VF defects patterns ,patients were divided int0 3 groups ,temporal quadrant visual field defect group, temporal vertical visual field defect group and tubular visual field group. Linear correlation analysis and variance analysis were applied to figure out the relationship within the field defect morphology, average mean sensitivity ( MS) . retinal nerve fiber layer ( RNFL) thickness and pituitary adenoma volume. Results RNFL thickness and the mean MS among the temporal quadrant visual field defect group ,temporal vertical visual field defect group and tubular visual field group had statistically significant difference ( all P = 0. 00) . the difference of pituitary adenoma volume in the three groups was not statistically significant (X2 = 0. 58 ,P = 0. 75 ) . In the temporal vertical visual field defect group and the tubular visual field group , average MS and the corresponding eye ’ s nasal RNFL thickness had linear relationship ( R2 = 0. 186 , t = 4. 76 . P = 0. 00 and R2 = 0. 146 .t = 2. 65 ,P = 0. 01 , respectively) , RNFL thickness and mean MS had no linear relationship with adenoma volume ( all P > 0. 05 ) . Conclusion Variety of VF defect are related to the location of pituitary adenoma. The VF defect degree has agreement with the mean MS,RNFL. Mean MS of the damage eye has agreement with corresponding RNFL thickness. VF defect pattern.RNFL thickness and mean MS has no correlation with the isolate factor of average pituitary adenoma volume.

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更新日期/Last Update: 2016-10-25