[1]时倩倩,刘华,付蓉花. 全视网膜光凝术对增生性糖尿病视网膜病变患者黄斑区视网膜功能的影响[J].眼科新进展,2015,35(4):362-365.[doi:10.13389/j.cnki.rao.2015.0097]
　SHI Qian-Qian,LIU Hua,FU Rong-Hua. Effects of panretinal photocoagulation on macular retina of patients with proliferative diabetic retinopathy[J].Recent Advances in Ophthalmology,2015,35(4):362-365.[doi:10.13389/j.cnki.rao.2015.0097]
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 全视网膜光凝术对增生性糖尿病视网膜病变患者黄斑区视网膜功能的影响
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年4期
页码:
362-365
栏目:
应用研究
出版日期:
2015-04-05

文章信息/Info

Title:
 Effects of panretinal photocoagulation on macular retina of patients with proliferative diabetic retinopathy
作者:
 时倩倩; 刘华; 付蓉花
 450000　河南省郑州市，郑州人民医院眼科
Author(s):
 SHI Qian-Qian ;  LIU Hua; FU Rong-Hua
 Department of Ophthalmology, People ’ s Hospital of Zhengzhou , Zhengzhou 450000 . Henan Province , China
关键词:
 ; 增生性糖尿病视网膜病变; 全视网膜光凝术; 多焦视网膜电图; 光学相干断层扫描
Keywords:
 ; proliferative diabetic retinopathy;  panretinal photocoagulation;  multifocal electroretinography;  optical coherence tomography
DOI:
10.13389/j.cnki.rao.2015.0097
文献标志码:
A
摘要:
 目的　观察全视网膜光凝术对增生性糖尿病视网膜病变（ｐｒｏｌｉｆｅｒａｔｉｖｅｄｉａｂｅｔｉｃｒｅｔｉｎｏｐａｔｈｙ，ＰＤＲ）患者黄斑区视网膜功能的影响。方法　选取２０１１年１月至２０１３年１２月我院收治的６０例（７２眼）ＰＤＲ患者作为观察组，同时选取６０例（６０眼）正常志愿者作为对照组。观察组患者均应用全视网膜光凝术进行治疗。两组均行裂隙灯、验光、眼压、眼底等常规眼部检查，利用光学相干断层扫描（ｏｐｔｉｃａｌｃｏｈｅｒｅｎｃｅｔｏｍｏｇｒａｐｈｙ，ＯＣＴ）检查黄斑区视网膜厚度，同时利用多焦视网膜电图（ｍｕｌｔｉｆｏｃａｌｅｌｅｃｔｒｏｒｅｔｉ-ｎｏｇｒａｍ，ｍｆ-ＥＲＧ）检查Ｐ１波、Ｎ１波５环的振幅密度及潜伏期等。结果　观察组患眼术前、术后黄斑中心凹视网膜厚度分别为（３４９．３±１１８．９）μｍ和（２６２．２±２８．２）μｍ，差异有统计学意义（Ｐ＜０．０５）；对照组黄斑中心凹视网膜厚度为（１３６．４±１７．８）μｍ，均显著低于观察组患眼手术前后黄斑中心凹视网膜厚度，差异均有统计学意义（均为Ｐ＜０.０５）。观察组患眼的１环、２环的术后Ｐ１波振幅密度较术前显著提高，差异均有统计学意义（均为Ｐ＜０．０５），而３环、４环、５环较术前显著降低，差异均有统计学意义（均为Ｐ＜０．０５）。观察组术后Ｐ１波潜伏期较术前均有一定程度的下降，差异均有统计学意义（均为Ｐ＜０．０５）。与对照组比较，观察组术后１环、２环的Ｐ１波潜伏期差异均有统计学意义（均为Ｐ＜０．０５）；３环、４环、５环差异均无统计学意义（均为Ｐ＞０．０５）。观察组术后１环、２环的Ｎ１波振幅较术前显著提高，差异均有统计学意义（均为Ｐ＜０．０５）；术后３环、４环、５环较术前显著降低，差异均有统计学意义（均为Ｐ＜０．０５）。观察组患眼术后３环的Ｎ１波潜伏期与术前比较，差异无统计学意义（Ｐ＞０.０５），术后１环、２环、４环、５环的Ｎ１波潜伏期均显著低于术前，差异均有统计学意义（均为Ｐ＜０．０５）。观察组术前和术后的Ｎ１波潜伏期均显著低于对照组，差异均有统计学意义（均为Ｐ＜０．０５）。结论　全视网膜光凝术治疗ＰＤＲ患者可显著改善视网膜的感光和传导功能，降低黄斑中心凹视网膜厚度，从而达到部分改善视力的目的。
Abstract:
 Objective To observe and analyze the effects of panretinal photocoagulation on macular retina of the patients with proliferative diabetic retinopathy (PDR). Methods Sixty cases of patients (72 eyes) with PDR were selected as the observation group, while 60 normal subjects (60 eyes) were selected as the control group. All of the patients in the observation group were treated with panretinal photocoagulation. The optical coherence tomography was applied to observe the retinal macular thickness before and after operation. and the amplitude densities and latencies of P1 wave. N1 wave at 5 rings were tested by using multifocal electroretinogram. Results The postoperative and postoperative foveal retinal thickness in the observation group were ( 349. 3 + 118. 9) p m and ( 262. 2 +28. 2) pm, respectively , there was statistical difference (P < 0. 05 ). The foveal retinal thickness in the control group was ( 136. 4 + 17. 8 ) ym , which were all lower than the postoperative and postoperative foveal retinal thickness in the observation group ( all P < 0. 05 ) . The postoperative amplitude densities of Pl wave at ring I , ring 2 0f the affected eyes in the observation group were higher than pre-operation( all P < 0. 05 ) . but which at ring 3 , ring 4 , ring 5 were lower than pre-operation ( all P < 0. 05) . The postoperative latencies of Pl wave in the observation group were lower than pre-operation ( all P < 0. 05 ) . Compared with the control group , there were statistical difference in the postoperative latency of Pl wave at ring I , ring 2 in the observation group ( all P < 0. 05 ) . but no statistical difference at ring 3 , ring 4 , ring 5 ( all P > 0. 05 ) . The postoperative amplitude densities of Nl wave at ring I , ring 2 0f the affected eyes in the observation group were higher than pre-operation( all P < 0. 05 ) . but which at ring 3 , ring 4 , ring 5 were lower than pre-operation ( all P < 0. 05 ) . Compared with pre-operation. there was no statistical difference in the postoperative latency of Nl wave at ring 3 0f the affected eyes in the observation group (P >0. 05 ) . but which at ring I , ring 2, ring 4 and ring 5 were lower than pre-operation ( all P < 0. 05 ) . The preoperative and postoperative latencies of Nl wave in the observation group were all lower than those in the control group ( all P < 0. 05 ) . Conclusions Panretinal photocoagulation can significantly improve the sensitivity and conduction function of retinal surgery in the treatment of PDR patients . decrease the foveal retinal thickness. so as to achieve the purpose of improving vision.

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更新日期/Last Update: 2015-03-31