[1]陈娟,周琼.朊蛋白在阿尔茨海默病视网膜退行性病变中的作用研究进展[J].眼科新进展,2015,35(1):081-83.[doi:10.13389/j.cnki.rao.2015.0023]
 CHEN Juan,ZHOU Qiong.Recent advances in role of Prion protein in Alzheimer ’ s retinal degeneration disease[J].Recent Advances in Ophthalmology,2015,35(1):081-83.[doi:10.13389/j.cnki.rao.2015.0023]
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朊蛋白在阿尔茨海默病视网膜退行性病变中的作用研究进展
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年1期
页码:
081-83
栏目:
文献综述
出版日期:
2015-01-05

文章信息/Info

Title:
Recent advances in role of Prion protein in Alzheimer ’ s retinal degeneration disease
作者:
陈娟周琼
330006 江西省南昌市,南昌大学医学院研究生院
Author(s):
CHEN Juan ZHOU Qiong
Graduate School of Medical School of Nanchang University . Nanchang 330006 , Jiangxi Province. China
关键词:
朊蛋白阿尔茨海默病视网膜退行性病变
Keywords:
Prion protein Alzheimer dieases retinal degeneration disease
DOI:
10.13389/j.cnki.rao.2015.0023
文献标志码:
A
摘要:
阿尔茨海默病(Alzheimerdieases,AD)是一种以认识和记忆损害为主要表现的中枢神经退行性病变,视觉损害是其最早出现的症状,包括对比敏感度、深度和运动感知的异常,其视网膜的病理改变为:视网膜神经节细胞的丢失和视神经的变性,主要特征为异常蛋白的堆积(β淀粉样蛋白、朊蛋白、tau蛋白)。朊蛋白的致病形式与神经元凋亡密切相关,而细胞型朊蛋白可以拮抗凋亡因子,对神经退行性病变有保护作用。本文对其相关研究进行综述。
Abstract:
Alzheimer’ s disease ( AD) is a kind of cognitive and memory impairment as the main manifestation of the central nervous system degeneration disease. Visual impairment is the earliest symptoms include abnormal contrast sensitivity, motion and depth perception ; The pathological changes of retina include ganglion cell loss and degeneration of optic nerve , mainly characterized by abnormal accumulation of protein ( B-amyloid protein , Prion protein , tau protein) . Pathogenic form of the Prion protein is closely related to neuronal apoptosis , however cellular Prion protein as an anti-apoptotic factor has the protective effect for neurodegenerative diseases. This article reviews related research.

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备注/Memo

备注/Memo:
国家自然科学基金资助(编号:81460092)
更新日期/Last Update: 2015-01-04