[1]张瑞雪,蒋文君,姜倩,等.透镜诱导条件下混合性近视和真性近视豚鼠屈光度和眼轴长度变化[J].眼科新进展,2021,41(6):511-513.[doi:10.13389/j.cnki.rao.2021.0106]
　ZHANG Ruixue,JIANG Wenjun,JIANG Qian,et al.Changes in diopter and axial length of guinea pigs with mixed myopia and true myopia under lens-induced conditions[J].Recent Advances in Ophthalmology,2021,41(6):511-513.[doi:10.13389/j.cnki.rao.2021.0106]
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透镜诱导条件下混合性近视和真性近视豚鼠屈光度和眼轴长度变化/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
41卷
期数:
2021年6期
页码:
511-513
栏目:
实验研究
出版日期:
2021-06-05

文章信息/Info

Title:
Changes in diopter and axial length of guinea pigs with mixed myopia and true myopia under lens-induced conditions
作者:
张瑞雪; 蒋文君; 姜倩; 刘德政; 吴建峰; 温莹; 毕宏生
250014　山东省济南市，山东中医药大学（张瑞雪，姜倩，刘德政，吴建峰）；250002　山东省济南市，山东中医药大学眼科研究所,山东省中西医结合眼病防治重点实验室（蒋文君，毕宏生）；250002　山东省济南市，山东中医药大学附属眼科医院（温莹，毕宏生）
Author(s):
ZHANG Ruixue1; JIANG Wenjun2; JIANG Qian1; LIU Dezheng1; WU Jianfeng1; WEN Ying3; BI Hongsheng2; 3
1.Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong Province,China
2.Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases,Eye Institute of Shandong University of Traditional Chinese Medicine,Jinan 250002，Shandong Province,China
3.Eye Hospital Affiliated to Shandong University of Traditional Chinese Medicine，Jinan 250002，Shandong Province,China
关键词:
屈光度; 眼轴长度; 混合性近视; 真性近视; 豚鼠
Keywords:
diopter;  axial length;  mixed myopia;  true myopia;  guinea pig
分类号:
R778.1
DOI:
10.13389/j.cnki.rao.2021.0106
文献标志码:
A
摘要:
目的　探讨-6.0 D透镜诱导条件下混合性近视和真性近视豚鼠屈光度和眼轴长度变化。方法　选取2周龄睫状肌麻痹前和麻痹后屈光度均在1.00～3.00 D之间的健康英国三色短毛豚鼠20只。将20只豚鼠适应性饲养3 d后，右眼配戴-6.0 D透镜，进行近视模型构建。依据透镜诱导2周后豚鼠睫状肌麻痹前后屈光度差值≥0.5 D且同时存在真性近视作为混合性近视的判断标准，将豚鼠分为混合性近视组和真性近视组,继续诱导至第8周，最终两组均为10只豚鼠。测量透镜诱导不同时间两组豚鼠屈光度和眼轴长度，并进行统计学分析。结果　透镜诱导2周、4周时混合性近视组与真性近视组豚鼠屈光度比较，差异均无统计学意义（均为P>0.05）。透镜诱导6周、8周时混合性近视组与真性近视组相比，睫状肌麻痹前、睫状肌麻痹后豚鼠屈光度均明显降低（均为P<0.05）。且透镜诱导8周时两组之间睫状肌麻痹前和睫状肌麻痹后豚鼠屈光度差值明显大于0周时（P<0.05）。透镜诱导2周、4周、6周时混合性近视组与真性近视组豚鼠眼轴长度比较，差异均无统计学意义（均为P>0.05）。透镜诱导8周时混合性近视组豚鼠眼轴长度明显长于真性近视组（P<0.05）。且透镜诱导8周时混合性近视组与真性近视组豚鼠眼轴长度差值明显大于0周时（P<0.05）。结论　混合性近视比真性近视豚鼠屈光度增加和眼轴增长更快，混合性近视中的假性近视成分应作为高度近视发展的预警指标。
Abstract:
Objective　To investigate the changes in diopter and axial length of mixed myopia and true myopia in guinea pigs induced by -6.0 D lens.Methods　Twenty healthy British tricolor short-haired guinea pigs with diopter between 1.00 D and 3.00 D before and after mydriasis at 2 weeks of age were selected. Twenty guinea pigs were adaptively fed for 3 days, and the right eyes worn -6.0 D lens to induce myopia. After 2 weeks of lens induction, mixed myopia was defined as the after-mydriasis diopter minus the before-mydriasis diopter ≥ 0.5 D, and there was true myopia at the same time, which was defined as mixed myopia. According to the criteria mentioned above, these guinea pigs were divided into mixed myopia group and true myopia group with 10 per group, and the induction was continued to the 8th week. The diopter and axial length of the two groups were measured and analyzed at different induction time.Results　There were no significant differences in diopter between mixed myopia group and true myopia group at 2 weeks and 4 weeks (both P>0.05). Compared with the true myopia group, the after-mydriasis diopter and pre-mydriasis diopter were significantly reduced in the mixed myopia group at 6 weeks and 8 weeks (all P<0.05). At 8 weeks, the difference of diopter between the two groups after-mydriasis diopter and pre-mydriasis diopter was significantly greater than that at 0 week (P<0.05). The axial length of the guinea pigs in the mixed myopia group was significantly longer than that in the true myopia group at 8 weeks (P<0.05), whereas no significant difference at 2 weeks, 4 weeks and 6 weeks (all P>0.05). At 8 weeks, the difference of axial length between mixed myopia group and true myopia group was significantly greater than that of 0 week (P<0.05).Conclusion　The diopter and axial length increase faster in mixed myopia guinea pigs than that in true myopia. The pseudomyopia in mixed myopia should be used as an early diagnosis parameter for high myopia.

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备注/Memo

备注/Memo:
国家重点研发计划项目（编号：2019YFC1710200、2019YFC1710204）；山东省重点研发计划（编号：2017CXGC1211、2018JHZ005、2019GSF108252）；山东省高等学校科技计划项目（编号：KJ2018BAL031）
更新日期/Last Update: 2021-06-05