[1]胡慧聪,张家豪,张妍,等.BMP4/Smad信号通路的分子机制及其在眼部疾病中的作用[J].眼科新进展,2021,41(4):391-396.[doi:10.13389/j.cnki.rao.2021.0082]
　HU Huicong,ZHANG Jiahao,ZHANG Yan,et al.Molecular mechanism of BMP4/Smad signaling pathway and its roles in ocular diseases[J].Recent Advances in Ophthalmology,2021,41(4):391-396.[doi:10.13389/j.cnki.rao.2021.0082]
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BMP4/Smad信号通路的分子机制及其在眼部疾病中的作用/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
41卷
期数:
2021年4期
页码:
391-396
栏目:
文献综述
出版日期:
2021-04-05

文章信息/Info

Title:
Molecular mechanism of BMP4/Smad signaling pathway and its roles in ocular diseases
作者:
胡慧聪; 张家豪; 张妍; 何宇茜
130041　吉林省长春市,吉林大学第二医院眼科中心（胡慧聪，张家豪，张妍，何宇茜）；130021　吉林省长春市,吉林大学白求恩医学部（胡慧聪，张家豪）
Author(s):
HU Huicong1; 2; ZHANG Jiahao1; 2; ZHANG Yan1;  HE Yuxi1
1.Department of Ophthalmology,2nd Hospital of Jilin University,Changchun 130041,Jilin Province,China
2.Orman Bethune Health Science Center of Jilin University,Changchun 130021,Jilin Province,China
关键词:
骨形成蛋白4; Smad; 眼部发育; 眼部组织; 眼部疾病
Keywords:
bone morphogenetic protein 4;  Smad;  eye development;  ocular tissues;  ocular diseases
分类号:
R77
DOI:
10.13389/j.cnki.rao.2021.0082
文献标志码:
A
摘要:
骨形成蛋白4（BMP4）通过Smad信号通路向下游传递信号，同时与Wnt/β-catenin、FGF等信号通路相互作用，调节一系列的病理生理活动。BMP4/Smad信号通路对眼具有重要作用。BMP4/Smad信号通路与眼前节、晶状体、视网膜的发育密切相关。同时，BMP4在成熟眼组织中高度表达，意味着BMP4/Smad信号通路与某些眼部疾病的发病机制有关。BMP4/Smad信号通路在维持角膜上皮稳态、视网膜神经的保护及修复方面起一定作用，同时还与青光眼、年龄相关性黄斑变性、增生型玻璃体视网膜病变等疾病的发生密切相关。本文主要讲述了BMP4/Smad信号通路的分子机制，并详细介绍了BMP4/Smad信号通路在眼发育和一些眼部疾病中的作用。
Abstract:
Bone morphogenetic protein 4 (BMP4) transmits signals to downstream signaling via Smad signaling pathway and can interact with Wnt/β-catenin, FGF and other signaling pathways to regulate a series of physiological and pathological activities. BMP4/Smad signaling pathway plays an important role in eye. It’s closely related to the development of anterior segment, lens, and retina. Meanwhile, BMP4 is highly expressed in adult ocular tissues, suggesting that BMP4/Smad signaling pathway is involved in the pathogenesis of some ocular diseases. BMP4/Smad signaling pathway plays a certain role in maintaining corneal epithelial homeostasis, protecting and repairing retinal nerves, and is also closely related to glaucoma, age-related macular degeneration, proliferative vitreoretinopathy and other diseases. In this review, we describe the molecular mechanism of BMP4/Smad signaling pathway and introduce the effects of BMP4/Smad signaling pathway on eye development and ocular diseases.

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备注/Memo

备注/Memo:
吉林省科技厅国际科技合作项目（编号：20200801016GH）；吉林省科技厅自然科学基金（编号:20180101146JC）；吉林省医疗卫生人才专项项目（编号：2019SCTZ052、2019SCTZ057、2020SCTZ089）
更新日期/Last Update: 2021-04-05