[1]李亚东,郑广瑛,骆瑶,等.形觉剥夺性弱视儿童脑灰质的变化：基于体素的形态测量研究[J].眼科新进展,2023,43(7):565-570.[doi:10.13389/j.cnki.rao.2023.0114]
　LI Yadong,ZHENG Guangying,LUO Yao,et al.Changes in gray matter volume in children with form-deprivation amblyopia by voxel-based morphometry[J].Recent Advances in Ophthalmology,2023,43(7):565-570.[doi:10.13389/j.cnki.rao.2023.0114]
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形觉剥夺性弱视儿童脑灰质的变化：基于体素的形态测量研究/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
43卷
期数:
2023年7期
页码:
565-570
栏目:
应用研究
出版日期:
2023-07-05

文章信息/Info

Title:
Changes in gray matter volume in children with form-deprivation amblyopia by voxel-based morphometry
作者:
李亚东; 郑广瑛; 骆瑶; 迟英杰; 文宝红; 张晓盼
450052　河南省郑州市，郑州大学第一附属医院眼科（李亚东，郑广瑛，骆瑶，迟英杰）；450052　河南省郑州市，郑州大学第一附属医院磁共振科（文宝红，张晓盼）
Author(s):
LI Yadong1; ZHENG Guangying1; LUO Yao1; CHI Yingjie1; WEN Baohong2; ZHANG Xiaopan2
1.Department of Ophthalmology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China
2.Department of Magnetic Resonance Imaging,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China
关键词:
形觉剥夺性弱视; 基于体素的形态测量学; 磁共振成像
Keywords:
form-deprivation amblyopia;  voxel-based morphometry;  magnetic resonance imaging
分类号:
R779.7
DOI:
10.13389/j.cnki.rao.2023.0114
文献标志码:
A
摘要:
目的　探讨形觉剥夺性弱视儿童全脑灰质体积（GMV）的变化。
方法　收集 2020年 8月至 2022 年1月于本院眼科中心就诊的形觉剥夺性弱视儿童25例35眼，其中单眼形觉剥夺性弱视组15例15眼、双眼形觉剥夺性弱视组10例20眼。同期门诊招募年龄、性别匹配的正常对照组受检者11名22眼。单眼形觉剥夺性弱视组、双眼形觉剥夺性弱视组和正常对照组受检者进行3.0T磁共振成像（MRI）扫描以获得结构像MRI图。应用基于体素的形态测量学（VBM）方法及脑成像数据处理和分析软件进行结构像MRI数据处理和统计分析，采用单因素方差分析对三组受检者之间的GMV进行比较。
结果　三组受检者之间总颅内容积的差异无统计学意义(P=0.379)。三组受检者之间GMV的差异有统计学意义(P=0.009)；其中单眼形觉剥夺性弱视组、双眼形觉剥夺性弱视组与正常对照组受检者之间GMV的差异均有统计学意义(P=0.004、0.019)，而单眼形觉剥夺性弱视组、双眼形觉剥夺性弱视组患者之间GMV的差异无统计学意义(P=0.673)。 与正常对照组相比，单眼形觉剥夺性弱视组患者在左侧颞中回、左侧楔叶和左侧额中回的GMV均减少（均为P<0.05），在左侧额上回、左侧额下回岛盖部、左侧顶上小叶、右侧颞下回和右侧小脑前叶的GMV均增加（均为P<0.05）。与正常对照组相比，双眼形觉剥夺性弱视组患者在右侧额叶、双侧小脑后叶、双侧小脑前叶和双侧海马旁回的GMV减少（均为P<0.05），在左侧颞上回和右侧顶上小叶的GMV增加（均为P<0.05）。与双眼形觉剥夺性弱视组相比，单眼形觉剥夺性弱视组患者在右侧楔前叶、右侧颞中回、右侧辅助运动区、左侧额中回、左侧前扣带回、左侧中央前回、双侧中扣带回、双侧岛叶和双侧中央后回的GMV增加（均为P<0.05），未见GMV显著减少的脑区（P>0.05）。
结论　形觉剥夺性弱视儿童脑灰质的改变不仅局限于初、高级视皮层，也涉及其他皮层及联络通路，且单、双眼弱视变化具有差异性。
Abstract:
Objective　To investigate the changes in gray matter volume (GMV) in children with form-deprivation amblyopia (FDA).
Methods　From August 2020 to January 2022,25 children (35 eyes) with FDA admitted to the Eye Center of our hospital were selected and divided into the monocular FDA group (15 children,15 eyes) and the binocular FDA group (10 children,20 eyes).During the same period,11 age- and gender-matched children (22 eyes) were enrolled in the normal control (NC) group.All children were examined with 3.0T magnetic resonance imaging (MRI) scanning to obtain structural images.Voxel-based morphometry (VBM) and brain imaging data processing & analysis software were used for structural image data processing and analysis.The GMV was compared among the three groups by one-way analysis of variance.
Results　No significant difference was found in total intracranial volume among the three groups (P=0.379),but there was a significant difference in GMV among the groups (P=0.009).GMV in the monocular and binocular FDA groups was significantly different from that in the NC group (P=0.004,P=0.019),but showed no significant difference between the monocular and binocular FDA groups (P=0.673).Compared with the NC group,the GMV in the monocular FDA group decreased in the left middle temporal gyrus,left cuneus,and left middle frontal gyrus,and increased in the left superior frontal gyrus,left opercular part of the inferior frontal gyrus,left superior parietal lobule,right inferior temporal gyrus,and right anterior cerebellar lobe (all P<0.05).Compared with the NC group,the GMV in the binocular FDA group decreased in the right frontal lobe,bilateral posterior cerebellar lobe,bilateral anterior cerebellar lobe,and bilateral parahippocampal gyrus,and increased in the left superior temporal gyrus and right superior parietal lobule (all P<0.05).Compared with the binocular FDA group,the GMV in the monocular FDA group increased in the right precuneus,right middle temporal gyrus,right supplementary motor area,left middle frontal gyrus,left anterior cingulate gyrus,left precentral gyrus,bilateral middle cingulate gyrus,bilateral insula,and bilateral postcentral gyrus (all P<0.05),but no significant reductions were observed in the brain regions (P>0.05).
Conclusion　The GMV changes in children with FDA are not only limited to the primary and higher visual cortices,but also related to other cortices and connecting pathways,and the changes are different between monocular and binocular amblyopia.

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更新日期/Last Update: 2023-07-05