[1]侯乃方,徐鑫令,王欣玲.环状非编码RNA在眼部疾病中表达研究进展[J].眼科新进展,2021,41(11):1077-1079.[doi:10.13389/j.cnki.rao.2021.0226]
 HOU Naifang,XU Xinling,WANG Xinling.Research progress on the expression of circular non-coding RNA in ocular diseases[J].Recent Advances in Ophthalmology,2021,41(11):1077-1079.[doi:10.13389/j.cnki.rao.2021.0226]
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环状非编码RNA在眼部疾病中表达研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
41卷
期数:
2021年11期
页码:
1077-1079
栏目:
文献综述
出版日期:
2021-11-05

文章信息/Info

Title:
Research progress on the expression of circular non-coding RNA in ocular diseases
作者:
侯乃方徐鑫令王欣玲
110000 辽宁省沈阳市,中国医科大学附属第四医院眼科,中国医科大学眼科医院,辽宁省晶状体重点实验室
Author(s):
HOU NaifangXU XinlingWANG Xinling
Department of Ophthalmology,the Forth Affiliated Hospital of China Medical University,Eye Hospital of China Medical University,Key Laboratory of Lens Research of Liaoning Province,Shenyang 110000,Liaoning Province,China
关键词:
环状非编码RNA眼部疾病基因调控竞争性内源RNA
Keywords:
circular non-coding RNA eye diseases gene regulation competitive endogenous RNA
分类号:
R77
DOI:
10.13389/j.cnki.rao.2021.0226
文献标志码:
A
摘要:
环状非编码RNA(circRNA)是指一类不具有5’末端帽子和3’末端poly(A)尾巴的一类非编码RNA,其通过共价键形成环形结构,它们可以通过几种不同的机制调节蛋白质的编码。越来越多的研究发现,circRNA在细胞增殖、分化、凋亡、血管生成、免疫调节等多种细胞功能中发挥一定的作用,从而导致多种疾病(如恶性肿瘤、炎症性疾病、神经系统疾病等)的发生。本文综述了circRNA在眼科疾病中的潜在作用和可能机制,以期能够为相关眼科疾病的早期诊断和不同阶段的治疗提供新的思路。
Abstract:
Circular non-coding RNA (circRNA) refers to a type of non-coding RNA that does not have a 5’-end cap and a 3’-end poly(A) tail.It forms a circular structure through covalent bonds.They can pass through several different mechanisms to regulate protein coding.More and more studies have found that circRNA plays a certain role in cell proliferation,differentiation,apoptosis,angiogenesis,immune regulation and other cell functions,resulting in a variety of diseases,including malignant tumors,inflammatory diseases,and nerve system diseases,etc.This article reviews the current status of research on the potential role and possible mechanism of circRNA in eye diseases,in order to provide new ideas for the early diagnosis and treatment of related eye diseases.

参考文献/References:

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备注/Memo

备注/Memo:
国家自然科学基金资助(编号:81570838)
更新日期/Last Update: 2021-11-05