[1]戎晗,顾珊珊,张国伟,等.非编码区单核苷酸多态性与眼部疾病关系的研究进展[J].眼科新进展,2016,36(4):380-385.[doi:10.13389/j.cnki.rao.2016.0104]
　RONG Han,GU Shan-Shan,ZHANG Guo-Wei,et al.Recent advances in relationship between SNPs in noncoding regions and ocular diseases[J].Recent Advances in Ophthalmology,2016,36(4):380-385.[doi:10.13389/j.cnki.rao.2016.0104]
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非编码区单核苷酸多态性与眼部疾病关系的研究进展
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年4期
页码:
380-385
栏目:
文献综述
出版日期:
2016-04-05

文章信息/Info

Title:
Recent advances in relationship between SNPs in noncoding regions and ocular diseases
作者:
戎晗; 顾珊珊; 张国伟; 康丽华; 管怀进
226001　江苏省南通市，南通大学附属医院眼科
Author(s):
RONG Han;  GU Shan-Shan;  ZHANG Guo-Wei;  KANG Li-Hua ;  GUAN Huai-Jin
Department of Ophthalmology , Affiliated Hospital of Nantong University, Nantong 226001 , Jiangsu Province . China
关键词:
单核苷酸多态性; 非编码区; 小分子RNA; 眼部疾病
Keywords:
single nucleotide polymorphism ;  non-coding region ;  microRNA ;  ocular diseases
DOI:
10.13389/j.cnki.rao.2016.0104
文献标志码:
A
摘要:
单核苷酸多态性与眼部疾病的发生、发展和预后有关联。ＭｉｃｒｏＲＮＡ是一类长为１８～２５ｎｔ的小分子非编码ＲＮＡ，它们通过与靶ｍＲＮＡ的３’ＵＴＲ区结合来调控基因表达。过去大量遗传关联研究发现，一些基因编码区的单核苷酸多态性与眼部疾病的易感性相关，但是很少涉及到一些基因非编码区如３’端非翻译区ｍｉＲＮＡ靶结合位点的遗传关联研究。本文就此研究进展作一简要综述。
Abstract:
Single nucleotide polymorphism ( SNP) is related to the occurrence . development and prognosis of some ocular diseases. MicroRNA is a class of about noncoding micro molecule RNA with 18 - 25 nucleotides long. They can regulate gene expression by binding t0 3 ’ UTR region of target mRNA. Previously many genetic studies have found that a number of SNP in gene coding regions were associated with the susceptibility of ocular diseases, but rarely involved some SNP in the non-coding regions, such as the nuRNA binding sites in the 3 ’ UTR region. This article reviews these progresses.

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备注/Memo

备注/Memo:
国家自然科学基金资助（编号：８１４７０６１６、８１５００７０６）
更新日期/Last Update: 2016-04-01