[1]刘晓涵,马宁,陈彦婷,等.圆锥角膜病因学研究进展——遗传、环境刺激、表观遗传的相互作用[J].眼科新进展,2020,40(12):1188-1192.[doi:10.13389/j.cnki.rao.2020.0264]
　LIU Xiaohan,MA Ning,CHEN Yanting,et al.Advances in the etiology of keratoconus——interations among genetic, environmental stimuli and epigenetics[J].Recent Advances in Ophthalmology,2020,40(12):1188-1192.[doi:10.13389/j.cnki.rao.2020.0264]
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圆锥角膜病因学研究进展——遗传、环境刺激、表观遗传的相互作用/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
40卷
期数:
2020年12期
页码:
1188-1192
栏目:
文献综述
出版日期:
2020-12-05

文章信息/Info

Title:
Advances in the etiology of keratoconus——interations among genetic, environmental stimuli and epigenetics
文章编号:
1188
作者:
刘晓涵; 马宁; 陈彦婷; 张钰; 陈跃国
100191　北京市，北京大学第三医院眼科
Author(s):
LIU Xiaohan; MA Ning; CHEN Yanting; ZHANG Yu; CHEN Yueguo
Department of Ophthalmology,Peking University Third Hospital,Beijing 100191,China
关键词:
圆锥角膜; 病因学; 遗传因素; 表观遗传; 体外模型
Keywords:
keratoconus;  etiology;  genetic factors;  epigenetics;  in vitro model
分类号:
R772.2
DOI:
10.13389/j.cnki.rao.2020.0264
文献标志码:
A
摘要:
圆锥角膜是一种扩张性角膜疾病，以角膜中央变薄、向前凸出呈锥状为特征，可严重影响视力。圆锥角膜病因复杂，迄今为止尚未完全明确，可能是遗传、表观遗传和环境刺激之间相互作用的结果。本文旨在对近年来圆锥角膜病因学的研究进展进行综述，并对未来该领域的研究方向进行展望：阐明表观遗传学的调控路径可能是明确病因的关键；3D培养的体外模型可望为探索圆锥角膜病因和推进治疗提供依据。
Abstract:
Keratoconus is a corneal ectasia disorder characterized by central corneal thinning and conical protrusion, which can cause severe visual impairment. The etiology of keratoconus is complex and still not well known. The interations among genetic, epigenetic and environmental stimuli may be involved in its pathogenesis. We intend to review the recent research progress on the etiology of keratoconus, and to prospect the future research directions in this field: to clarify the epigenetic regulatory path could be the key to define its etiology, and human cell-based 3D in vitro tissue engineered model is expected to provide basis for exploring the etiology and promoting the treatment of keratoconus.

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备注/Memo

备注/Memo:
北京大学第三医院临床重点项目创新项目A类（编号：Y65495-05）
更新日期/Last Update: 2020-12-05