[1]徐漫,孙荔,刘永珍,等. Belin角膜扩张分析鉴别早期圆锥角膜的敏感性与特异性[J].眼科新进展,2015,35(5):456-459.[doi:10.13389/j.cnki.rao.2015.0124]
　XU Man,SUN Li,LIU Yong-Zhen,et al. Sensitivity and specificity of Belin/Ambrosio Enhanced Ectasia Display in discriminating subclinical keratoconus[J].Recent Advances in Ophthalmology,2015,35(5):456-459.[doi:10.13389/j.cnki.rao.2015.0124]
点击复制

 Belin角膜扩张分析鉴别早期圆锥角膜的敏感性与特异性
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年5期
页码:
456-459
栏目:
应用研究
出版日期:
2015-05-05

文章信息/Info

Title:
 Sensitivity and specificity of Belin/Ambrosio Enhanced Ectasia Display in discriminating subclinical keratoconus
作者:
 徐漫; 孙荔; 刘永珍; 卢迪; 徐艳春; 陈蕾
 110001　辽宁省沈阳市，中国医科大学附属第一医院眼科
Author(s):
 XU Man; SUN Li;  LIU Yong-Zhen ;  LU Di ; XU Yan-Chun; CHEN Lei
 Department of Ophthalmology,the First Affiliated Hospital of China Medical University, Shenyang 110001,Liaoning Province,China
关键词:
 ; 圆锥角膜; Belin角膜扩张分析; Pentacam三维眼前节分析系统
Keywords:
 ; keratoconus ;  Belin/Ambrosio Enhanced Ectasia Display ;  Pentacam
DOI:
10.13389/j.cnki.rao.2015.0124
文献标志码:
A
摘要:
 目的　探讨Ｂｅｌｉｎ角膜扩张分析鉴别早期圆锥角膜的敏感性和特异性。方法　选取２０１１年１月至２０１４年６月在我院眼科门诊就诊的圆锥角膜患者４６例（４６眼）为研究对象，其中临床期组２３例２３眼，亚临床期组２３例２３眼，同时选取正视或低度近视５０例（５０眼）为对照组。应用Ｐｅｎｔａｃａｍ三维眼前节分析系统，对每个患者进行双眼Ｂｅｌｉｎ角膜扩张分析检测，并将角膜前表面扩张分析差异值（ｄｉｆｆｅｒｅｎｃｅ-ｆｒｏｎｔ，Ｂｆ）、角膜后表面扩张分析差异值（ｄｉｆｆｅｒｅｎｃｅ-ｂａｃｋ，Ｂｂ）、角膜前表面差异偏差值（ｄｅｖｉａｔｉｏｎｏｆｆｒｏｎｔｅｌｅｖａｔｉｏｎｄｉｆｆｅｒｅｎｃｅｍａｐ，Ｄｆ）、角膜后表面差异偏差值（ｄｅｖｉａｔｉｏｎｏｆｂａｃｋｅｌｅｖａｔｉｏｎｄｉｆｆｅｒｅｎｃｅｍａｐ，Ｄｂ）、角膜平均进展差异偏差值（ｄｅｖｉａｔｉｏｎｏｆａｖｅｒａｇｅｐａｃｈｙｍｅｔｒｉｃｐｒｏｇｒｅｓ-ｓｉｏｎ，Ｄｐ）、角膜最薄点偏差值（ｄｅｖｉａｔｉｏｎｏｆｍｉｎｉｍｕｍｔｈｉｃｋｎｅｓｓ，Ｄｔ）、ＡＲＴｍａｘ偏差值（ｄｅｖｉａｔｉｏｎｏｆＡＲＴｍａｘ，Ｄａ）、总偏差值（ｔｏｔａｌｄｅ-ｖｉａｔｉｏｎｖａｌｕｅ，ＦｉｎａｌＤ）进行Ｍａｎｎ-ＷｈｉｔｎｅｙＵ检验及受试者工作特征（ｒｅｃｅｉｖｅｒｏｐｅｒａｔｉｎｇｃｈａｒａｃｔｅｒｉｓｔｉｃ，ＲＯＣ）曲线分析。结果　临床期组、亚临床期组和对照组Ｂｅｌｉｎ角膜扩张分析参数，除亚临床期组与对照组中Ｄｔ（Ｐ＝０．５４５）、Ｄａ（Ｐ＝０.２３５）差异无统计学意义外，其余参数在３组间两两比较差异均有统计学意义（均为Ｐ＜０．０５）。临床期组相对于对照组中ＦｉｎａｌＤ的曲线下面积最大，为０．９９７，Ｂｂ、Ｄｆ、Ｄｂ、Ｄｐ、Ｄａ均＞０．９００，Ｂｆ、Ｄｔ均＞０．８００。亚临床期组相对于对照组Ｄｂ的曲线下面积最大，为０．８３９，Ｂｂ为０.８１２，ＦｉｎａｌＤ为０．７８９，Ｂｆ、Ｄｆ、Ｄｐ均＞０．６００，Ｄｔ与Ｄａ均＞０．５００。亚临床期组相对于对照组Ｄｂ的敏感性最大，为０．８７０，Ｄｐ的特异性最大，为０．９２０。结论　Ｂｅｌｉｎ角膜扩张分析可以将早期圆锥角膜从正常角膜中区分开来，具有较高的敏感性和特异性，但需要复诊进一步鉴别。
Abstract:
 Objective To estimate the sensitivity and specificity of Belin/Ambrosio Enhanced Ectasia Display in discrinunating subclinical keratoconus from normal corneas. Methods Forty-six keratoconus patients (46 eyes) at subclinical stage and clinical stage ( Rabinowitz diagnosis standards) . and 50 normal eyes from 50 subjects with emmetropia or low myopia from the first Affiliated Hospital of China Medical University during January 2014 to June 2014 were enrolled in this research. Belin/Ambrosio Enhanced Ectasia Display of both eyes from each patient were examined by Pentacam Scheimpflug. The Mann-Whitney U test. ROC curve were used to compare the mean measurements and evaluate the sensitivity and specificity of difference-front ( Bf) . difference-back ( Bb) , deviation of average map ( Df) , deviation of back elevation difference map ( Db) . deviation of average pachymetric progression ( Dp) , deviation of minimum thickness ( Dt) , deviation of ARTmax ( Da) . total deviation value ( FinaID ) . Results Except for Dt( P = 0. 545 ) and Da( P = 0. 235 ) . other parameters had more significant changes among subclinical keratoconus . clinical keratoconus and normal group( all P <0. 05 ) . The ROC curve analyses showed FinaID had the best AUC ( 0. 997 ) , Bb.Df. Db ,Dp , Da > 0. 900 in clinical keratoconus and normal group. Db had the highest AUC (0. 839) , Bb > 0. 800 . FinaID > 0. 700 , Bf , Df , Dp > 0. 600 , Dt , Da > 0. 500 in subclinical keratoconus and normal group. The best sensitivity and specificity in subclinical keratoconus nd normal group was Db ( 0. 870) and Dp ( 0. 920) , respectively. Conclusion Belin/Ambrosio Enhanced Ectasia Display can discrinunate subclinicl keratoconus from normal corneas .however . the subsequent visit is needed to reconfirm.

相似文献/References:

[1]王向华 赵宏 丁相奇.两种深板层角膜移植术治疗圆锥角膜的比较研究[J].眼科新进展,2012,32(4):000.
[2]吴东芳 张小兰 邱乐梅 王顺清 孙成淑 邓应平.圆锥角膜的诊断与治疗[J].眼科新进展,2012,32(12):000.
[3]罗畅 邓应平.性别及年龄对圆锥角膜发病与进展的影响[J].眼科新进展,2013,33(2):000.
[4]韩莎莎 王婷 孟丽丽 史伟云.深板层及穿透性角膜移植术治疗圆锥角膜术后屈光状态的比较[J].眼科新进展,2013,33(9):000.
[5]韦伟 杨晓钊 张长宁 朱秀萍.Comfort-Kone硬性角膜接触镜矫治圆锥角膜的临床观察[J].眼科新进展,2012,32(1):000.
[6]王海燕 赵少贞 郝永娜 魏瑞华.圆锥角膜患者人口统计学及临床特点分析[J].眼科新进展,2012,32(3):000.
[7]陆燕 杨丽萍 葛轶睿 薛春燕 陈祥菲 王春红 黄振平.飞秒激光辅助的深板层角膜移植术治疗圆锥角膜及角膜扩张症[J].眼科新进展,2013,33(10):000.
[8]刘平 苏胜. 白内障蛋白质组学研究的现状及未来研究方向[J].眼科新进展,2014,34(1):001.
[9]杨宝娣 宋艳萍 陈中山 丁琴. 微脉冲半导体激光对兔视网膜色素上皮细胞阈值下光凝的光生物调制效应[J].眼科新进展,2014,34(1):005.
[10]赖伟霞 梁皓 谭少健 李霞 邹文进 蒋林志. 钙调素在正常人及不同年龄白内障患者晶状体上皮细胞中的表达[J].眼科新进展,2014,34(1):010.

更新日期/Last Update: 2015-04-27