[1]王月,王雪,底煜.长链非编码RNA在早产儿视网膜病变中的作用研究进展[J].眼科新进展,2020,40(11):1097-1100.[doi:10.13389/j.cnki.rao.2020.0244]
　WANG Yue,WANG Xue,DI Yu.Research progress of long non-coding RNA in retinopathy of prematurity[J].Recent Advances in Ophthalmology,2020,40(11):1097-1100.[doi:10.13389/j.cnki.rao.2020.0244]
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长链非编码RNA在早产儿视网膜病变中的作用研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
40卷
期数:
2020年11期
页码:
1097-1100
栏目:
文献综述
出版日期:
2020-11-05

文章信息/Info

Title:
Research progress of long non-coding RNA in retinopathy of prematurity
作者:
王月; 王雪; 底煜
110134　辽宁省沈阳市，中国医科大学附属盛京医院眼科
Author(s):
WANG Yue; WANG Xue; DI Yu
Department of Ophthalmology,Shengjing Hospital of China Medical University,Shenyang 110134,Liaoning Province,China
关键词:
长链非编码RNA; 早产儿视网膜病变; 血管内皮生长因子; 视网膜新生血管
Keywords:
long non-coding RNA;  retinopathy of prematurity;  vascular endothelial growth factor;  retinal neovascularization
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2020.0244
文献标志码:
A
摘要:
在围产医学水平不断提升的条件下，早产儿存活率明显提升，加之二胎政策的开放以及辅助生殖技术的进步，高龄产妇和多胎妊娠相对增多，早产儿视网膜病变（retinopathy of prematurity,ROP）作为常见的早产儿缺氧性疾病也呈现出高发病率趋势。目前普遍认为早产儿的发病原因为缺血缺氧，但其发生发展机制仍有待深入研究。近年来，关于长链非编码RNA(long non-coding RNA,lncRNA)在ROP及其他视网膜新生血管性疾病中的作用已有大量的相关研究。本文旨在综述lncRNA的表达与调控对ROP发生发展的影响，为临床控制与治疗ROP提供理论基础。
Abstract:
With the continuous improvement of perinatal medicine, there is a significant rise in premature infant survival rate. In addition to the implement of two-child policy and the advancement of assisted reproductive technology, the proportion of elderly parturient and multiple pregnancy has relatively increased. Retinopathy of prematurity, as a common hypoxic disease of premature infants, also presents a high incidence trend. Currently, it has been generally believed that ischemia and hypoxia are the basic pathogenesis of premature infants ,but the mechanism of its generative and developmental mechanism still needs to be studied further. Related research on long non-coding RNA provides a new direction for that. In recent years, a number of experimental researches on long non-coding RNA in premature retinopathy and other retinal neovascular diseases have been carried out. The purpose of this paper is to review the expression and regulation of lncRNA, and its influence in the occurrence and development of ROP, which will provide theoretical basis for clinical control and treatment of ROP.

参考文献/References:

［1］　LIANG J H,CHENG Y.Be cautious to treat retinopathy of prematurity with anti-vascular endothelial growth factor pharmacotherapy［J］.Chin J Ophthalmol,2019,55(4):246-249.
［2］　BAI Y C,NIE H J,WEI S J,LU X H,KE X Y,OUYANG X J,et al，Efficacy of intravitreal conbercept injection in the treatment of retinopathy of prematurity［J］.Br J Ophthalmol,2019,103(4):494-498.
［3］　AICH M, CHAKRABORTY D.Role of lncRNAs in stem cell maintenance and differentiation［J］.Curr Top Dev Biol,2019,138:73-112.
［4］　GUI Z Q,WEI T,FU H T,LI C P,LIU B.Long non-coding RNA-MEG3 is involved in diabetes mellitus-related microvascular dysfunction［J］.Biochem Biophys Res Commun,2016,471(1):135-141.
［5］　CHEN W W,YANG S,ZHOU Z L,ZHAO X T,ZHONG J Y,REINACH P S,et al.The long noncoding RNA landscape of the mouse eye［J］.Invest Ophthalmol Vis Sci,2017,58(14):6308-6317.
［6］　FANG L,BARBER A J,SHENBERGER J S.Regulation of fibroblast growth factor 2 expression in oxygen-induced retinopathy［J］.Invest Ophthalmol Vis Sci,2015,56(1):207-215.
［7］　HUGHES C P,OFLYNN M J,GATHERER M,MICHELLE E,SCOTT J A,MACLAREN R E,et al.AAV2/8 anti-angiogenic gene therapy using single-chain antibodies inhibits murine choroidal neovascularization［J］.Mol Ther Methods Clin Dev,2019,13(1):86-98.
［8］　SMITH L H,WESOLOIUSKI E,ANGELA M K,MCLELLAN A,KOSTYK K,DAMATO R,et al.Oxygen-induced retinopathy in the mouse［J］.Invest Ophthalmol Vis Sci,1994,35(1):101-111.
［9］　SHAN K,XIAO Q W,YANG N,HONG Y,MU D Y,CHANG L.Role of long non-coding IA-RNCR3 in athemsclemsis-related Vascular dysfuction［J］.Cell Death Dis,2016,27(6)：e2248．
［10］　PENG F,WANG Y,WANG Y P,WANG B B,ZHOU X Y,WU S Y,et al.Expression profile of long non-coding RNA in newborn mice with oxygen-induced retinopathy［J］.Chin J Perinatal Med，2018，21（1）：48-54.
［11］　LI X,ZHAO F,LI G,LUNA C,ZHOU Q,HE Y Y,et al.Regulation of intraocular pressure by microRNA cluster miR143/145［J］.Sci Rep,2017,7(1):915.
［12］　漆晨，韩倩，薄其玉，刘勋，王飞，张琰,等．氧诱导视网膜病变小鼠模型的蛋白表达谱分析［J］.中华实验眼科杂志，2015，12（4）：1069-1075．
QI C,HAN Q,BO Q Y,LIU X,WANG F,ZHANG Y,et al.Analysis of protein expression profiling in a mouse model of oxygen-induced retinopathy［J］.Chin J Exp Ophthalmol，2015，12（4）：1069-1075.
［13］　HEIDUSCHKA P,PLAGEMANN T,LI L,ALEX A F,ETER N.Different effects of various anti-angiogenic treatments in an experimental mouse model of retinopathy of prematurity［J］.Clin Exp Ophthalmol,2019,47(1):79-87.
［14］　ILOTT N E,HEWARD J A,ROUX B,TSITSIOU E,FENXICK P S,LENZI L,et al.Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes［J］.Nat Commun,2014,5(3979):1-13.
［15］　WANG P,XUE Y Q,LIN L,WU C,XU S,JIANG Z P,et al.The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation［J］.Science,2014,344(6181):310-313.
［16］　NIEMINEN T,SCOTT T A,LIN F M,CHEN Z,YLA H,MORRIS K V.Long non-coding RNA modulation of VEGF-A during hypoxia［J］.Non-Coding RNA,2018,4(34):1-16.
［17］　YAN B A,YAO J,LIU J Y,LI X M,WANG X Q,LI Y J,et al.lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA［J］.Circ Res,2015,116(7):1143-1156.
［18］　CHI H L,WAN Y S,JOHN P,CHEN J.Retinal expression of small non-coding RNAs in a murine model of proliferative retinopathy［J］.SCI Rep-UK,2016,6:33947.
［19］　DI Y,ZHANG Y O,NIE Q Z,CHEN X L.CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy［J］.Int J Mol Med,2015,36(6):1507-1518.
［20］　DI Y,CHEN X L.Inhibition of LY294002 in retinal neovascularization via down-regulation the PI3K/AKT-VEGF pathway in vivo and in vitro［J］.Int J Ophthalmol,2018,11(8):1284-1289.
［21］　YOUNG T L,MATSUDA T,CEPKO C L.The noncoding RNA taurine upregulated gene 1 is required for differentiation of the murine retina［J］.Curr Bio,2005,15(29):501-502.
［22］　WU X, ZHENG X, CHENG J, ZHANG K, MA C CHEN D C,et al.LncRNA TUG1 regulates proliferation and apoptosis by regulating miR-148b/IGF2 axis in ox-LDL-stimulated VSMC and HUVEC［J］.Life Sci,2020,243:117287.
［24］　JIANG Q, SHAN K,WANG X Q, ZHOU R M, YANG H, LIU C,et al.Long non-coding RNA-MIAT promotes neurovascular remodeling in the eye and brain［J］.Oncotarget,2016,7(31):49688-49698.
［25］　LIU P,JIA S,SHI J M,LI W J,TANG L S,ZHU X H,et al.LncRNA-MALAT1 promotes neovascularization in diabetic retinopathy through regulating miR-125b/VE-cadherin axis［J］.Bioscience Rep,2019,39(5):BSR20181469.
［26］　NAWAZ M I,VANRAEMDONCK K,MOHAMMAD G,KANGAVE D,ABUEL A M.Autocrine CCL2,CXCL4,CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy［J］.Exp Eye Res,2013,109(1):67-76.
［27］　PISTOL G C ,MARIN D E ,ROTAR M C,ROPOTA M.Bioactive compounds from dietary whole grape seed meal improved colonic inflammation via inhibition of mapks and NF-κB signaling in pigs with DSS induced colitis［J］.J Funct Foods,2020,66:103708.
［28］　ASANO D,MORITA A,MORI A,SAKAMOTO K,ISHII K,NAKAHARA T.Involvement of matrix metalloproteinases in capillary degeneration following NMDA-induced neurotoxicity in the neonatal rat retina［J］.Exp Eye Res,2019,182:101-108.
［29］　CEHN W W,ZHANG J,ZHANG P J,HU F Y,JIANG T T,GU J X,et al.Role of TLR4-MAP4K4 signaling pathway in models of oxygen-induced retinopathy［J］.FASEB J,2019,33(3):3451-3464.
［30］　RUAN W C,ZHAO F,ZHAO S Y,ZHANG L Y,SHI L,PANG T.Knockdown of long noncoding RNA MEG3 impairs VEGF-stimulated endothelial sprouting angiogenesis via modulating VEGFR2 expression in human umbilical vein endothelial cells［J］.Gene,2018,649(1):32-39.

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备注/Memo

备注/Memo:
国家自然科学基金资助（编号：81600747）
更新日期/Last Update: 2020-11-05