[1]周召,林启,邵毅.角膜神经性疼痛诊治进展[J].眼科新进展,2020,40(11):1090-1096.[doi:10.13389/j.cnki.rao.2020.0243]
 ZHOU Zhao,LIN Qi,SHAO Yi.Detection and the current feasible treatment of neuropathic corneal pain[J].Recent Advances in Ophthalmology,2020,40(11):1090-1096.[doi:10.13389/j.cnki.rao.2020.0243]
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
40卷
期数:
2020年11期
页码:
1090-1096
栏目:
文献综述
出版日期:
2020-11-05

文章信息/Info

Title:
Detection and the current feasible treatment of neuropathic corneal pain
作者:
周召林启邵毅
330006 江西省南昌市,南昌大学第一临床附属医院
Author(s):
ZHOU ZhaoLIN QiSHAO Yi
Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China
关键词:
角膜神经性疼痛抗炎症疗法神经再生系统用药保护性隐形眼镜辅助疗法
Keywords:
neuropathic corneal painanti-inflammation neuro-regenerationpharmcotherapeutic strategiesprotective contact lensesadjuvant therapies
分类号:
R722.2
DOI:
10.13389/j.cnki.rao.2020.0243
文献标志码:
A
摘要:
角膜神经性疼痛是一种定义不明的疾病。针对角膜神经性疼痛患者的临床建议、检测方法和治疗方法十分缺乏。目前基于对神经性疼痛病理生理学上的研究,临床上已有一些可行的检测方法和治疗方法,其中检测方法包括使用活性染料的裂隙灯检查法、触觉测量计、丙美卡因挑战测试法、体内共焦距显微镜检测。治疗方法包括抗炎症疗法、神经再生性疗法、系统用药、使用保护性隐形眼镜和一些辅助疗法。本文旨在总结针对其可行的检测方法和治疗方法。
Abstract:
Neuropathic corneal pain is an ill-defined illness. Clinical recommendations and treatments for patients are scarce. Nowadays, based on researches of the pathophysiology of neuropathic pain, there are some feasible methods for detection and treatments including slit lamp inspection using reactive dyes, tactile meters, proparacaine challenge test, and in vivo confocal microscopy, as well as anti-inflammation therapy, neuro-regenerative therapy, systemic pharmacotherapy, using protective contact lenses, pharmcotherapeutic strategies and some adjuvant therapies. This review summarizes some current feasible detection methods and treatments.

参考文献/References:

[1] TREEDE R D,JENSEN T S,CAMPBELL J N,CRUCCU G,DOSTROVSKY J O,GRIFFIN J W,et al.Carpathian pain:redefinition and a grading system for clinical and research purposes[J].Neurology,2008,70(18):1630-1635.
[2] VAN HECKE O,AUSTIN S K,KHAN R A et al.Neuropathic pain in the general population:a systematic review of epidemiological studies[J].Pain,2014,155:654-662.
[3] ROSENTHAL P,BORSOOK D,MOULTON E A.Oculofacial pain:Corneal nerve damage leading to pain beyond the eye[J].Invest Ophthalmol Vis Sci,2016,57(13):5285-5287
[4] GOYAL S,HAMRAH P.Understanding neuropathic corneal pain-gaps and current therapeutic approaches[J].Semin Ophthalmol,2016,31(1-2):59-70.
[5] MCMONNIES C W.The potential role of neuropathic mechanisms in dry eye syndromes[J].J Optom,2017,10(1):5-13.
[6] HEGARTY D M,HERMES S M,YANG K,AICHER S A.Select noxious stimuli induce changes on corneal nerve morphology[J].J Comp Neurol,2017,525(8):2019-2031.
[7] YANG A Y,CHOW J,LIU J.Corneal innervation and sensation:The eye and beyond[J].Yale J Biol Med,2018,91(1):13-21.
[8] BELMONTE C,ACOSTA M C,GALLAR J.Neural basis of sensation in intact and injured corneas[J].Exp Eye Res,2004,78(3):513-525.
[9] PROKOPETC K,BARTOLI A.SLIM(slit lamp image mosaicing):handling reflection artifacts[J].Int J Comput Assist Radiol Surg,2017,12(6):911-920.
[10] BUNYA V Y,CHEN M,ZHENG Y,MASSARO-GIORDANO M,GEE J,DANIEL E,et al.Development and evaluation of semiautomated quantification of lissamine green staining of the bulbar conjunctiva from digital images[J].JAMA Ophthalmol,2017,135(10):1078-1085.
[11] DIECKMANN G,GOYAL S,HAMRAH P.Neuropathic corneal pain:approaches for management[J].Ophthalmology,2017,124(11 Suppl):S34-S47.
[12] THULASI P,DJALILIAN A R.Update in current diagnostics and therapeutics of dry eye disease[J].Ophthalmology,2017,124(11S):S27-S33.
[13] SACCHETTI M,LAMBIASE A.Neurotrophic factors and corneal nerve regeneration[J].Neural Regen Res,2017,12(8):1220-1224.
[14] WEN Q,FAN T,BAI S,SUI Y.Cytotoxicity of proparacaine to human corneal endothelial cells in vitro[J].J Toxicol Sci,2015,40(4):427-436
[15] MCLACHLAN E M,HU P.Inflammation in dorsal root ganglia after peripheral nerve injury: effects of the sympathetic innervation[J].Auton Neurosci,2014,182:108-117.
[16] SHEPPARD J D,COMSTOCK T L,CAVET M E.Impact of the topical ophthalmic corticosteroid loteprednol etabonate on intraocular pressure[J].Adv Ther,2016,33(4):532-552.
[17] AMON M,BUSIN M.Loteprednol etabonate ophthalmic suspension 0.5%:efficacy and safety for postoperative anti-inflammatory use[J].Int Ophthalmol,2012,32(5):507-517.
[18] OTHMAN T M,MOUSA A,GIKANDIP W,ABDELMABOD M,ABDELRAHMAN A M.Efficacy and safety of using topical cyclosporine A for treatment of moderate to severe dry eye disease[J].Saud J Ophthalmol,2018,32( 3):217-221.
[19] LALLEMAND F,SCHMITT M,BOURGES J L,GURNY R,BENITA S,GARRIGUE J S.Cyclosporine A delivery to the eye:A comprehensive review of academic and industrial efforts[J].Eur J Pharm Biopharm,2017,117:14-28.
[20] FABIANI C,SOTA J,TOSI G M,FRANCESCHINI R,FREDIANI B,GALEAZZI M,et al.The emerging role of interleukin(IL)-1 in the pathogenesis and treatment of inflammatory and degenerative eye diseases[J].Clin Rheumatol,2017,36(10):2307-2318.
[21] ZHANG L,SU Z,ZHANG Z,LIN J,LI D Q,PFLUGFELDER S C.Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatorymediators in the eyelid margin and conjunctiva of patients with meibomian gland disease[J].JAMA Ophthalmol,2015,133(10):1117-1123.
[22] HIGUCHI A.Autologous serum and serum components[J].Invest Ophthalmol Vis Sci,2018,59(14):DES121-DES129.
[23] READ SP,RODRUGUEZ M,DUBOVY S,KARP C L,GALOR A.Treatment of refractory filmentary keratitis with autoglogous serum tears[J].Eye Contact Lens,2017,43(5):e16-e18.
[24] TAHMAZ V,GEHLSEN U,SAUERBIER L,HOLTICK U,ENGEL L,RADOJSKA S,et al.Treatment of severe chronic ocular graft-versus-host disease using 100% autologous serum eye drops from a sealed manufacturing system:a retrospective cohort study[J].Br J Ophthalmol,2017,101(3):322-326.
[25] ABEDI F,HAMRAH P.Corneal subbasal nerve recovery in an acute case of ultraviolet keratitis treated with autologous serum eye drops[J].J Opthalmol,2018,2018:49054873
[26] MIAN S Z,AGRANAT J S,JACOBS D S.Prosthetic replacement of the Ocular Surface Ecosystem(PROSE) treatment for complications after LASIK[J].Eye Contact Lens,2016,42(6):371-373.
[27] SINDRUP S H,OTTO M,FINNERUP N B,JENSEN T S.Antidepressants in the treatment of neuropathic pain[J].Basic Clin Pharmacol Toxicol,2005,96(6):399-409.
[28] GILLMAN P K.Tricyclic antidepressant pharmacology and therapeutic drug interactions updated[J].Br J Pharmacol,2007,151(6):737-748.
[29] ROLLMAN B L,BLOCK M R,SCHULLBERG H C.Symptoms of major depression and tricyclic side effects in primary care patients[J].J Gen Intern Med,1997,12(5):284-291.
[30] AL-QULITI K W.Update on neuropathic pain treatment for trigeminal neuralgia.The pharmacological and surgical options[J].Neurosciences(Riyadh),2015,20(2):107-114.
[31] HUTCHINSON M R,ZHANG Y,BROWN K,COATS B D,SHRIDHAR M,SHOLAR PW,et al.Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone:involvement of toll-like receptor 4(TLR4)[J].Eur J Neurosci,2008,28(1):20-29.
[32] PINEDA-FARIAS J B,CARAM-SALAS N L,SALINAS-ABARCA A B,OCAMPO J,GRANADOS-SOTO V.Ultra-low doses of naltrexone enhance the antiallodynic effect of pregabalin or gabapentin in neuropathic rats[J].Drug Dev Res,2017,78(8):371-380.
[33] DUEHMKE R M,DERRY S,WIFFEN P J,BELL R F,ALDINGTON D,MOORE R A.Tramadol for neuropathic pain in adults[J].Cochrane Database Syst Rev,2017,6:CD003726.
[34] WIFFEN P J,DERRY S,BELL R F,RICE A S,TOLLE TR,PHILLIPS T,et al.Gabapentin for chronic neuropathic pain in adults[J].Cochrane Database Syst Rev,2017,2017(6) :CD007938.
[35] FINNERUP NB,ATTAL N,HAROUTOUNIAN S,MCNICOL E,BARON R,DWORKIN RH,et al.Pharmacotherapy for neuropathic pain in adults:a systematic review and meta-analysis[J].Lancet Neurol,2015,14(2):162-173.
[36] LI J,YE L.Effect of pregabalin for the treatment of chronic refractory cough:A case report[J].Medicine(Baltimore),2019,98(23):e15916.
[37] LI J,CHEN X,LU X,ZHANG C,SHI Q,FENG L.Pregabalin treatment of peripheral nerve damage in amurine diabetic peripheral neuropathy model[J].Acta Endocrinol(Buchar),2018,14(3):294-299.
[38] MENG J,ZHANG Q,YANG C,XIAO L,XUE Z,ZHU J.Duloxetine,a balanced serotonin-norepinephrine reuptake inhibitor,improves painful chemotherapy-induced peripheral neuropathy by inhibiting activation of p38 MAPK and NF-κB[J].Front Pharmacol,2019,10:365.
[39] POLYCHRONIOU P E,MAYBERG H S,CRAIGHEAD W E,RAKOFSKY J J,APONTE RIVERA V,HAROON E,et al.Temporal profiles and dose-responsiveness of side effects with escitalopram and duloxetine in Treatment-Na ve Depressed Adults[J].Behav Sci(Basel),2018,8(7):64.
[40] WANG J,LI Q,XU B,ZHANG T,CHEN S,LUO Y.Efficacy and safety of duloxetine in Chinese breast cancer patients with paclitaxel-induced peripheral neuropathy[J].Chin J Cancer Res,2017,29(5):411-418.
[41] GALLAGHER H C,GALLAGHER R M,BUTLER M,BUGGY DJ,HENMAN MC.Venlafaxine for neuropathic pain in adults[J].Cochrane Database Syst Rev,2015,8:CD011091.
[42] KOPSKY D J,KEPPEL HESSELINK J M.Topical phenytoin for the treatment of neuropathic pain[J].J Pain Res,2017,10:469-473.
[43] JU Z Y,WANG K,CUI H S,YAO Y,LIU S M,ZHOU J,et al.Acupuncture for neuropathic pain in adults[J].Cochrane Database Syst Rev,2017,12:CD012057.
[44] JIN Y,XING G,LI G,WANG A,FENG S,TANG Q,et al.High frequency repetitive transcranial magnetic stimulation therapy for chronic neuropathic pain:A meta-analysis[J].Pain Physician,2015,18(6):E1029-1046.
[45] PARK H S,KIM W J,KIM H G,YOO S H.Scrambler therapy for the treatment of neuropathic pain related to leukemia in a pediatric patient:A case report[J].Medicine(Baltimore),2017,96(45):e8629.
[46] ALMEIDAl C,DEMAMAN A,KUSUDA R,CADETTI F,RAVANELLI M I,QUEIROZ A L,et al.Exercise therapy normalizes BDNF upregulation and glial hyperactivity in a mouse model of neuropathic pain[J].Pain,2015,156(3):504-513.
[47] WENDELL S G,BAFFI C,HOLGUIN F.Fatty acids,inflammation,and asthma[J].J Allergy Clin Immunol,2014,133(5):1255-1264.
[48] ZIS P,SARRIGIANNIS P G,RAO D G,HADJIVASSILIOU M.Gluten neuropathy:prevalence of neuropathic pain and the role of gluten-free diet[J].J Neurol,2018,265(10):2231-2236.

备注/Memo

备注/Memo:
国家自然科学基金资助(编号:81660158);江西省自然科学基金重大项目(编号:2016ACB21017); 江西省青年科学基金(编号:20151BAB215016,20161BAB215198);江西省重点研发项目(编号:20151BBG70223,20181BBG70004); 江西省杰出青年人才计划(S2019RCQNB0259);江西省学位与研究生教育教学改革研究项目(编号:JXYJG-2018-013);江西省基层卫生适宜技术“星火推广计划”项目(编号:20188003);江西省卫计委科技计
更新日期/Last Update: 2020-11-05