参考文献/References:
[1] GUCCIARDO E,LOUKOVAARA S,SALVEN P,LEHTI K.Lymphatic vascular structures:a new aspect in proliferative diabetic retinopathy[J].Int J Mol Sci,2018,19(12):4034.
[2] BOYNTON G E,STEM M S,KWARK L,JACKSON G R,FARSIU S,GARDNER T W.Multimodal characterization of proliferative diabetic retinopathy reveals alterations in outer retinal function and structure[J].Ophthalmology,2015,122(5):957-967.
[3] AHSAN H.Diabetic retinopathy - Biomolecules and multiple pathophysiology[J].Diabetes Metab Syndr,2015,9(1):51-54.
[4] XIE M,HU A,LUO Y,SUN W,HU X,TANG S.Interleukin-4 and melatonin ameliorate high glucose and interleukin-1β stimulated inflammatory reaction in human retinal endothelial cells and retinal pigment epithelial cells[J].Mol Vis,2014,20(6):921-928.
[5] TSAI T,KUEHN S,TSIAMPALIS N,VU M-K,KAKKASSERY V,STUTE G,et al.Anti-inflammatory cytokine and angiogenic factors levels in vitreous samples of diabetic retinopathy patients[J].PLoS One,2018,13(3):e0194603.
[6] SIM R,HERNNDEZ C.Novel approaches for treating diabetic retinopathy based on recent pathogenic evidence[J].Prog Retin Eye Res,2015,48:160-180.
[7] STITT A W,CURTIS T M,CHEN M,MEDINA R J,MCKAY G J,JENKINS A,et al.The progress in understanding and treatment of diabetic retinopathy[J].Prog Retin Eye Res,2016,51:156-186.
[8] TOLENTINO M S,TOLENTINO A J,TOLENTINO M J.Current and investigational drugs for the treatment of diabetic retinopathy[J].Expert Opin Investig Drugs,2016,25(9):1011-1022.
[9] YU Y,CHEN H,SU S B.Neuroinflammatory responses in diabetic retinopathy[J].J Neuroinflammation,2015,12(1):141.
[10] GENG Y,YU Y,LIU T,LU L,LI D,YU H,et al.Levels of inflammatory cytokines IL-1β,IL-6,IL-8,IL-17A,and TNF-α in aqueous humour of patients with diabetic retinopathy[J].J Diabetes Res,2018,2018(1):1-6.
[11] KAUL K,HODGKINSON A M,TARR J M,KOHNER E,CHIBBER R.Is inflammation a common retinal-renal-nerve pathogenic link in diabetes?[J].Curr Diabetes Rev,2010,6(5):294-303.
[12] AL-KHARASHI A S.Role of oxidative stress,inflammation,hypoxia and angiogenesis in the development of diabetic retinopathy[J].Saudi J Ophthalmol,2018,32(4):318-323.
[13] GARCIA F A,REBOUAS J F,BALBINO T Q,SILVA T G,CARVALHO-JNIOR C H,CERQUEIRA G S,et al.Pentoxifylline reduces the inflammatory process in diabetic rats:relationship with decreases of pro-inflammatory cytokines and inducible nitric oxide synthase[J].J Inflamm,2015,12(1):33.
[14] CAO Y L,ZHANG F Q,HAO F Q.Th1/Th2 cytokine expression in diabetic retinopathy[J].Genet Mol Res,2016,15(3):gmr.15037311.
[15] VARGAS-ROJAS M I,SOLLEIRO-VILLAVICENCIO H,SOTO-VEGA E.Th1,Th2,Th17 and Treg levels in umbilical cord blood in preeclampsia[J].J Matern Fetal Neonatal Med,2016,29(10):1-14.
[16] KORN T,BETTELLI E,OUKKA M,KUCHROO V K.IL-17 and TH17 cells[J].Annu Rev Immunol,2009,27(1):485-517.
[17] KONG F,ZHANG W,FENG B,ZHANG H,RAO H,WANG J,et al.Abnormal CD4+T helper (Th) 1 cells and activated memory B cells are associated with type III asymptomatic mixed cryoglobulinemia in HCV infection[J].Virol J,2015,12(1):100.
[18] NAHOMI R B,SAMPATHKUMAR S,MYERS A M,ELGHAZI L,SMITH D G,TANG J,et al.The absence of indoleamine 2,3-Dioxygenase inhibits retinal capillary degeneration in diabetic mice[J].Invest Ophthalmol Vis Sci,2018,59(5):2042-2053.
[19] JOHNSEN-SORIANO S,SANCHO-TELLO M,ARNAL E,NAVEA A,CERVERA E,BOSCH-MORELL F,et al.IL-2 and IFN-gamma in the retina of diabetic rats[J].Graefes Arch Clin Exp Ophthalmol,2010,248(7):985-990.
[20] HUANG H,GANDHI J K,ZHONG X,WEI Y,GONG J,DUH E J,et al.TNF is required for late BRB breakdown in diabetic retinopathy,and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis[J].Invest Ophthalmol Vis Sci,2011,52(3):1336-1344.
[21] JOUSSEN A M,DOEHMEN S,LE M L,KOIZUMI K,RADETZKY S,KROHNE T U,et al.TNF-alpha mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations[J].Mol Vis,2009,15(151):1418-1428.
[22] LI H,ZHANG J,LIN L,XU L.Vascular protection of DPP-4 inhibitors in retinal endothelial cells in in vitro culture[J].Int Immunopharmacol,2019,66:162-168.
[23] KOLEVAGEORGIEVA D N,SIVKOVA N P,TERZIEVA D.Serum inflammatory cytokines IL-1beta,IL-6,TNF-alpha and VEGF have influence on the development of diabetic retinopathy[J].Folia Med,2011,53(2):44-50.
[24] DEMIRCAN N,SAFRAN B G,SOYLU M,OZCAN A A,SIZMAZ S.Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy[J].Eye,2006,20(12):1366-1369.
[25] SFIKAKIS P P,MARKOMICHELAKIS N,THEODOSSIADIS G P,GRIGOROPOULOS V,KATSILAMBROS N,THEODOSSIADIS P G.Regression of sight-threatening macular edema in type 2 diabetes following treatment with the anti-tumor necrosis factor monoclonal antibody infliximab[J].Diabetes Care,2005,28(2):445-447.
[26] HKANSSON K,BACHERT C,KONGE L,THOMSEN S F,PEDERSEN A E,POULSEN S S,et al.Airway inflammation in chronic rhinosinusitis with nasal polyps and asthma:the united airways concept further supported[J].PLoS One,2015,10(7):e0127228.
[27] HANG H,YUAN S,YANG Q,YUAN D,LIU Q.Multiplex bead array assay of plasma cytokines in type 2 diabetes mellitus with diabetic retinopathy[J].Mol Vis,2014,20(4):1137-1145.
[28] WU H,HWANG D K,SONG X,TAO Y.Association between aqueous cytokines and diabetic retinopathy stage[J].J Ophthalmol,2017,2017:1-8.
[29] CHEN H,ZHANG X,LIAO N,WEN F.Assessment of biomarkers using multiplex assays in aqueous humor of patients with diabetic retinopathy[J].BMC Ophthalmol,2017,17(1):176.
[30] PETROVI C ˇ M G,KOROEC P,KONIK M,HAWLINA M.Association of preoperative vitreous IL-8 and VEGF levels with visual acuity after vitrectomy in proliferative diabetic retinopathy[J].Acta Ophthalmol,2010,88(8):e311-e316.
[31] RACZYSKA D,LISOWSKA K A,PIETRUCZUK K,BORUCKA J, S ′ LIZIE M,RACZYSKA K,et al.The level of cytokines in the vitreous body of severe proliferative diabetic retinopathy patients undergoing posterior vitrectomy[J].Curr Pharm Des,2018,24(27):3276-3281.
[32] HAOSHEN S,BERGER E A.Characterization of site-specific phosphorylation of NF-κB p65 in retinal cells in response to high glucose and cytokine polarization[J].Mediators Inflamm,2018,2018:3020675.
[33] TAKEUCHI M,SATO T,TANAKA A,MURAOKA T,TAGUCHI M,SAKURAI Y,et al.Elevated levels of cytokines associated with Th2 and Th17 cells in vitreous fluid of proliferative diabetic retinopathy patients[J].PLoS One,2015,10(9):e0137358.
[34] SUN J,LIU C.Correlation of vascular endothelial function and coagulation factors with renal function and inflammatory factors in patients with diabetic nephropathy[J].Exp Ther Med,2018,16(5):4167-4171.
[35] MA Y,TAO Y,LU Q,JIANG Y R.Intraocular expression of serum amyloid a and interleukin-6 in proliferative diabetic retinopathy[J].Am J Ophthalmol,2011,152(4):678-685.
[36] GUSTAVSSON C,AGARDH C D,AGARDH E.Profile of intraocular tumour necrosis factor-α and interleukin-6 in diabetic subjects with different degrees of diabetic retinopathy[J].Acta Ophthalmol,2013,91(5):445-452.
[37] ADAMIEC-MROCZEK J,OFICJALSKA-MYCZAK J,MISIUK-HOJO M.Roles of endothelin-1 and selected proinflammatory cytokines in the pathogenesis of proliferative diabetic retinopathy:Analysis of vitreous samples[J].Cytokine,2010,49(3):269-274.
[38] FUNATSU H,YAMASHITA H,NOMA H,MIMURA T,NAKAMURA S,SAKATA K,et al.Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients[J].Graefes Arch Clin Exp Ophthalmol,2005,243(1):3-8.
[39] YAO Y,LI R,DU J,LONG L,LI X,LUO N.Interleukin-6 and Diabetic Retinopathy:A systematic review and meta-analysis[J].Curr Eye Res,2019:44(5):564-574.
[40] YU Y,ZHANG J,ZHU R,ZHAO R,CHEN J,JIN J,et al.The profile of angiogenic factors in vitreous humor of the patients with proliferative diabetic retinopathy[J].Curr Mol Med,2017,17(4):280-286.
[41] SEN A,PAINE S K,CHOWDHURY I H,MUKHERJEE A,CHOUDHURI S,SAHA A,et al.Impact of interleukin-6 promoter polymorphism and serum interleukin-6 level on the acute inflammation and neovascularization stages of patients with Eales’ disease[J].Mol Vis,2011,17:2552-2563.
[42] MY S ′ LIWIEC M,ZORENA K,BALCERSKA A,MY S ′ LIWSKA J,LIPOWSKI P,RACZYSKA K.The activity of -acetyl-beta--glucosaminidase and tumor necrosis factor-alpha at early stage of diabetic retinopathy development in type 1 diabetes mellitus children[J].Clin Biochem,2006,39(8):851-856.
[43] HERNNDEZ C,SEGURA R M,FONOLLOSA A,CARRASCO E,FRANCISCO G,SIM R.Interleukin-8,monocyte chemoattractant protein-1 and IL-10 in the vitreous fluid of patients with proliferative diabetic retinopathy[J].Diabet Med,2010,22(6):719-722.
[44] BROMBERG-WHITE J L,GLAZER L,DOWNER R,FURGE K,BOGUSLAWSKI E,DUESBERY N S.Identification of VEGF-Independent cytokines in proliferative diabetic retinopathy vitreous[J].Invest Ophthalmol Vis Sci,2013,54(10):6472-6480.
[45] DONG N,XU B,CHU L,TANG X.Study of 27 aqueous humor cytokines in type 2 diabetic patients with or without macular edema[J].PLoS One,2015,10(4):e0125329.
[46] TAKEUCHI M,SATO T,SAKURAI Y,TAGUCHI M,HARIMOTO K,KARASAWA Y,et al.Association between aqueous humor and vitreous fluid levels of Th17 cell-related cytokines in patients with proliferative diabetic retinopathy[J].PLoS One,2017,12(5):e0178230.
[47] HIROTA K,AHLFORS H,DUARTE J H,STOCKINGER B.Regulation and function of innate and adaptive interleukin-17-producing cells[J].EMBO Rep,2012,13(2):113-120.
[48] LIU S,LIN Y,LIU X.Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression[J].Exp Ther Med,2015,11(1):257-263.
[49] CHEN H,REN X,LIAO N,WEN F.Th17 cell frequency and IL-17A concentrations in peripheral blood mononuclear cells and vitreous fluid from patients with diabetic retinopathy[J].Int Med Res,2016,44(6):1403-1413.
[50] CHERNYKH V V,VARVARINSKY E V,SMIRNOV E V,CHERN-YKH D V,TRUNOV A N.Proliferative and inflammatory factors in the vitreous of patients with proliferative diabetic retinopathy[J].Indian J Ophthalmol,2015,63(1):33-36.
[51] QIU A W,LIU Q H,WANG J L.Blocking IL-17A alleviates diabetic retinopathy in rodents[J].Cell Physiol Biochem,2017,41(3):960-972.
[52] JIANG H,KUANG H Y.Inflammatory cytokines and diabetic retinopathy[J].Int J Endocrinal Metab,2007,27:31-33.
[53] HAN J,LI Y,LIU X,ZHOU T,SUN H,EDWARDS P,et al.Metformin suppresses retinal angiogenesis and inflammation in vitro and in vivo[J].PLoS One,2018,13(3):e0193031.
[54] CHEN X,HAN R,HAO P,WANG L,LIU M,JIN M,et al.Nepetin inhibits IL-1β induced inflammation via NF-κB and MAPKs signaling pathways in ARPE-19 cells[J].Biomed Pharmacother,2018,101:87-93.
[55] BOGDANOV P,SOL-ADELL C,HERNNDEZ C,GARCA-RAMREZ M,SAMPEDRO J,SIM-SERVAT O,et al.Calcium dobesilate prevents the oxidative stress and inflammation induced by diabetes in the retina of db/db mice[J].J Diabetes Complicat,2017,31(10):1481-1490.
[56] JU H B,ZHANG F X,WANG S,SONG J,CUI T,LI L F,et al.Effects of fenofibrate on inflammatory cytokines in diabetic retinopathy patients[J].Medicine,2017,96(31):e7671.
[57] YI X,SUN J,LI L,WEI Q,QIAN Y,CHEN X,et al.1,25-Dihydroxyvitamin D3 deficiency is involved in the pathogenesis of diabetic retinopathy in the uygur population of China[J].IUBMB Life,2016,68(6):445-451.
[58] LEI X,HE J,REN C,ZHOU Y,CHEN X,DOU J.Protective effects of the Chinese herbal medicine prescription Zhujing pill on retina of streptozotocin-induced diabetic rats[J].Biomed Pharmacother,2018,98:643-650.
[59] LEI X,ZHOU Y,REN C,CHEN X,SHANG R,HE J,et al.Typhae pollen polysaccharides ameliorate diabetic retinal injury in a streptozotocin-induced diabetic rat model[J].J Ethnopharmacol,2018,224:169-176.
[60] DONGARE S,GUPTA S K,MATHUR R,SAXENA R,MATHUR S,AGARWAL R,et al.Zingiber officinale attenuates retinal microvascular changes in diabetic rats via anti-inflammatory and antiangiogenic mechanisms[J].Mol Vis,2016,22:599-609.
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