[1]殷学伟,刘滨,毕宏生,等.单核苷酸多态性与葡萄膜炎发生的研究进展[J].眼科新进展,2018,38(8):790-793.[doi:10.13389/j.cnki.rao.2018.0187]
　YIN Xue-Wei,LIU Bin,BI Hong-Sheng,et al.Research advances in relationship between single nucleotide polymorphisms and the occurrence of uveitis[J].Recent Advances in Ophthalmology,2018,38(8):790-793.[doi:10.13389/j.cnki.rao.2018.0187]
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单核苷酸多态性与葡萄膜炎发生的研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
38卷
期数:
2018年8期
页码:
790-793
栏目:
文献综述
出版日期:
2018-08-05

文章信息/Info

Title:
Research advances in relationship between single nucleotide polymorphisms and the occurrence of uveitis
作者:
殷学伟; 刘滨; 毕宏生; 郭大东
250014　山东省济南市，山东中医药大学［殷学伟（2017级硕士研究生），刘滨（2016级硕士研究生）］；250002　山东省济南市，山东省中西医结合眼病防治重点实验室，山东中医药大学眼科研究所（郭大东，毕宏生）
Author(s):
YIN Xue-Wei; LIU Bin; BI Hong-Sheng; GUO Da-Dong
Shandong University of Traditional Chinese Medicine（YIN Xue-Wei，LIU Bin），Jinan 250014，Shandong Province，China；Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases，Eye Institute of Shandong University of Traditional Chinese Medicine（GUO Da-Dong，BI Hong-Sheng）,Jinan 250002,Shandong Province,China
关键词:
单核苷酸多态性; 葡萄膜炎; 易感基因
Keywords:
single nucleotide polymorphism; uveitis; susceptible gene
分类号:
R773
DOI:
10.13389/j.cnki.rao.2018.0187
文献标志码:
A
摘要:
葡萄膜炎是一类临床常见的致盲性眼病，病因复杂，可造成眼组织不可逆性损害。单核苷酸多态性（single nucleotide polymorphisms，SNPs）是个体间表型差异的主要原因，可以影响人类疾病的发展。SNPs是由DNA序列上单个碱基变异造成的，具有髙频、稳定和易分析等特点，是研究疾病易感基因的重要手段。近年来文献报道，基因SNPs与葡萄膜炎发病密切相关，本文就基因SNPs与葡萄膜炎发生的相关性研究进展进行综述，为葡萄膜炎相关性研究提供思路。
Abstract:
Uveitis is a series of common，complicated blinding eye diseases in clinical practice，which can lead to irreversible damage to the eye tissues.Single nucleotide polymorphisms (SNPs) are primary causes for phenotype differences among individuals，affecting the development of various diseases of human beings.The SNPs are caused by mutation of single base from DNA strand，possessing the characteristics of high frequency，stability and easy analysis.Recently，a lot of literatures reported that SNPs are closely related to the occurrence and development of uveitis.The present paper reviewed the recent advances in the relationship between SNPs and the development of uveitis，providing a new insight into the investigation of uveitis.

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备注/Memo

备注/Memo:
国家自然科学基金（编号：81674032）；山东省自然科学基金（编号：ZR2016HP27，ZR2017-LH042）；山东中医药科技发展计划（编号：2015-145）
更新日期/Last Update: 2018-08-09