[1]周?莉,张红.飞秒激光辅助的白内障手术对2型糖尿病患者术中房水细胞因子表达的影响[J].眼科新进展,2018,38(8):786-789.[doi:10.13389/j.cnki.rao.2018.0186]
　ZHOU Yan-Li,ZHANG Hong.Effects of femtosecond laser assisted cataract surgery on the expression of aqueous cytokine in patients with type 2 diabetes mellitus[J].Recent Advances in Ophthalmology,2018,38(8):786-789.[doi:10.13389/j.cnki.rao.2018.0186]
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飞秒激光辅助的白内障手术对2型糖尿病患者术中房水细胞因子表达的影响/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
38卷
期数:
2018年8期
页码:
786-789
栏目:
应用研究
出版日期:
2018-08-05

文章信息/Info

Title:
Effects of femtosecond laser assisted cataract surgery on the expression of aqueous cytokine in patients with type 2 diabetes mellitus
作者:
周?莉; 张红
300384　天津市，天津医科大学眼科医院，天津医科大学眼视光学院，天津医科大学眼科研究所（周?莉现工作于武汉爱尔眼科医院）
Author(s):
ZHOU Yan-Li; ZHANG Hong
Tianjin Medical University Eye Hospital，School of Optometry and Ophthalmology，Tianjin Medical University Eye Institute （ZHOU Yan-Li now works in Wuhan Aier Eye Hospital），Tianjin 300384，China
关键词:
飞秒激光; 白内障; 糖尿病; 房水细胞因子
Keywords:
femtosecond laser; cataract; diabetes mellitus; aqueous cytokine
分类号:
R776.1
DOI:
10.13389/j.cnki.rao.2018.0186
文献标志码:
A
摘要:
目的　检测合并2型糖尿病的白内障患者行飞秒辅助的白内障手术时术中房水中前列腺素E2（prostaglandin E2，PGE2）、白细胞介素6（interleukin 6，IL-6）、白细胞介素1β（interleukin 1β，IL-1β）、肿瘤坏死因子α（tumor necrosis factor α，TNF-α）及血管内皮生长因子（vascular endothelial growth factor，VEGF）的浓度，并探讨其和术后糖尿病黄斑水肿（diabetes macular edema，DME）的关系。方法　前瞻性队列研究。将在武汉爱尔眼科医院接受飞秒激光辅助的白内障手术112例（112眼）患者纳入本研究，并按是否合并2型糖尿病分成两组：糖尿病组61例（61眼），对照组51例（51眼）。在飞秒激光步骤完成之后立即收集2组房水样本。采用酶联免疫吸附方法检测房水样本中PGE2、IL-6、IL-1β、TNF-α及VEGF的浓度。术前及术后均使用OCT检测并比较2组患者的黄斑中央区厚度。结果　糖尿病组房水样本中PGE2浓度为（87.4±12.1）ng·L-1、IL-6浓度为（39.7±6.6）ng·L-1、IL-1β浓度为（59.2±7.2）ng·L-1、TNF-α浓度（6.3±1.0）ng·L-1、VEGF浓度为（274.1±40.4）ng·L-1；对照组房水样本中PGE2浓度为（67.6±9.4）ng·L-1、IL-6浓度为（24.8±5.7）ng·L-1、IL-1β浓度为（27.1±5.3）ng·L-1、TNF-α浓度（3.1±0.5）ng·L-1、VEGF浓度为（189.7±17.6）ng·L-1。糖尿病组房水样本中的PGE2、IL-6、IL-1β、TNF-α及VEGF的浓度均明显高于对照组（均为P<0.01）。房水样本中PGE2、IL-6、IL-1β、TNF-α及VEGF的浓度释放与年龄、性别、激光固定时间及激光作用时间均无相关性（均为P>0.05）。糖尿病组术前黄斑中央区厚度为（142.5±7.6）μm，术后为（166.5±13.6）μm，术前术后无明显差异（P>0.05）。对照组术前黄斑中央区厚度为（139.4±10.2）μm，术后为（156.2±7.0）μm，术前术后差异无统计学意义（P>0.05）。结论　飞秒激光辅助的白内障手术中糖尿病患者术前术后黄斑中央区厚度均未发现明显差异，且所有患者均未出现术后黄斑水肿。
Abstract:
Objective　To investigate aqueous humour concentrations of PGE2，IL-6，IL-1β，TNF-α，VEGF in patients with diabetes mellitus undergoing femtosecond laser-assisted cataract surgery and the potential relationship to postoperative diabetes macular edema (DME).Methods　Prospective consecutive nonrandomized comparative cohort study was conducted in 112 eyes of 112 patients undergoing femtosecond laser-assisted cataract surgery who were divided into 2 groups，and 61 eyes from 61 patients with diabetes mellitus were DM group，while 51 eyes from 51 non-diabetic patients were control group.And 100 μL aqueous humour was collected after laser treatment.Human PGE2，IL-6，IL-1β，TNF-α and VEGF ELISA kits were used to determine the concentrations of PGE2，IL-6，IL-1β，TNF-α and VEGF in the aqueous humour.Central foveal thickness was measured using OCT before and after surgery，and DME was defined as an 30% increase in foveal thickness after operation.All patients were treated with non-steroidal anti-inflammatory drugs prior to surgery.Results　For PGE2，IL-6，IL-1β，TNF-α and VEGF，the mean concentration values in aqueous humour were (87.4±12.1)ng·L-1，(39.7±6.6)ng·L-1，(59.2±7.2)ng·L-1，(6.3±1.0)ng·L-1，(274.1±40.4)ng·L-1 in the DM group，and (67.6±9.4)ng·L-1，(24.8±5.7)ng·L-1，(27.1±5.3)ng·L-1，(3.1±0.5)ng·L-1，(189.7±17.6)ng·L-1in the control group，respectively.Concentrations of PGE2，IL-6，IL-1β，TNF-α and VEGF were significantly higher in the DM group than those in the control group (all P<0.01).There no significant correlations between concentrations of PGE2，IL-6，IL-1β，TNF-α or VEGF and age，sex，cataract densities，suction time or laser time (all P>0.05).In DM group，the mean fovea thickness was (142.5±7.6)μm preoperatively and (166.5±13.6)μm postoperatively，and difference was not significant (P>0.05).In control group，the mean fovea thickness was (139.4±10.2)μm preoperatively and (156.2±7.0)μm postoperatively，and difference was not significant (P>0.05).Conclusion　Aqueous humour concentrations of PGE2，IL-6，IL-1β，TNF-α，VEGF were significantly higher in the DM group than those in the control group after femtosecond laser treatment，but there was no significant difference in the retinal thickness of the macular fovea before and after the operation and no cystoid macular edema was found in the two groups.

参考文献/References:

［1］　OLAFSDOTTIR E，ANDERSSON D K G，STEFANSSON E.The prevalence of cataract in a population with and without type 2 diabetes mellitus［J］.Acta Ophthalmol，2012，90（4）：334-342.
［2］　ROBERTS T V，LAWLESS M，BALI S J，HODGE C，SUTTON G.Surgical outcomes and safety of femtosecond laser cataract surgery：a prospective study of 1500 consecutive cases［J］.Ophthalmology，2013，120（2）：227-233.
［3］　OSTRI C，LUND-ANDERSEN H，SANDER B，LACOUR M.Phacoemulsification cataract surgery in a large cohort of diabetes patients：visual acuity outcomes and prognostic factors［J］.J Cataract Refract Surg，2011，37（11）：2006-2012.
［4］　SCHULTZ T，JOACHIM S C，KUEHN M，DICK H B.Changes in prostaglandin levels in patients undergoing femtosecond laser-assisted cataract surgery［J］.J Refract Surg，2013，29（11）：742-747.
［5］　NICOLE R，BENITA H，JORGE G，ARROYO.Pseudophakic cystoid macular edema［J］.Int Ophthalmol Clin，2010，50（1）：139-153.
［6］　ASANO S，MIYAKE K，OTA I，SUGITA G，KIMURA W，SAKKA Y，et al.Reducing angiographic cystoid macular edema and blood-aqueous barrier disruption after small-incision phacoemulsification and foldable intraocular lens implantation：multicenter prospective randomized comparison of topical diclofenac 0.1% and betamethasone 0.1%［J］.J Cataract Refract Surg，2008，34（1）：57-63.
［7］　ERIKSSON U，ALM A，BJRNHALL G，GRANSTAM E，MATSSON A W.Macular edema and visual outcome following cataract surgery in patients with diabetic retinopathy and controls［J］.Graefes Arch Clin Exp Ophthalmol，2011，249（3）：349-359.
［8］　MUNK M R，KISS C G，HUF W，MONTUORO A，SULZBACHER F，KROH M，et al.Visual acuity and microperimetric mapping of lesion area in eyes with inflammatory cystoid macular edema［J］.Acta Ophthalmol，2014，92（4）：332-338.
［9］　HENDERSON B A，KIM J Y，AMENT C S，FERRUFINO-PONCE Z K，GRABOWSKA A，CREMERS S L.Clinical pseudophakic cystoid macular edema；risk factors for development and duration after treatment［J］.J Cataract Refract Surg，2007，33（9）：1550-1558.
［10］　NAGY Z，TAKACS A，FILKORN T，SARAYBA M.Initial clinical evaluation of an intraocular femtosecond laser in cataract surgery［J］.J Refract Surg，2009，25（12）：1053-1060.
［11］　JUN J H，HWANG K Y，CHANG S D，JOO C K.Pupil-size alterations induced by photodisruption during femtosecond laser-asisted cataract surgery［J］.J Cataract Refract Surg，2015，41（2）：278-285.
［12］　SCHULTZ T，JOACHIM S C，SZULER M，STELLBOGEN M，DICK H B.NSAID Pretreatment Inhibits Prostaglandin Release in Femtosecond Laser-Assisted Cataract Surgery［J］.J Refract Surg，2015，31（12）：791-794.
［13］　NAGY Z Z，TAKACS A I，FILKORN T，KRáNITZ K，GYENES A，JUHáSZ é，et al.Complications of femtosecond laser-assisted cataract surgery［J］.J Cataract Refract Surg，2014，40（1）：20-28.
［14］　LOBO C.Pseudophakic cystoid macular edema［J］.Ophthalmologica，2012，227（1）：61-67.
［15］　CHAUDHARY C，BAHADHUR H，GUPTA N.Study of cystoid macular edema by optical coherent tomography following uneventful cataract surgery［J］.Int Ophthalmol，2015，35（5）：685-691.

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更新日期/Last Update: 2018-08-09