[1]王静,赵江月,陆璐,等.液体浸润式飞秒激光平台辅助的白内障手术初步研究[J].眼科新进展,2018,38(1):044-48.[doi:10.13389/j.cnki.rao.2018.0009]
　WANG Jing,ZHAO Jiang-Yue,LU Lu,et al.Preliminary clinical research on liquid-immersion femtosecond laser assisted cataract surgery[J].Recent Advances in Ophthalmology,2018,38(1):044-48.[doi:10.13389/j.cnki.rao.2018.0009]
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液体浸润式飞秒激光平台辅助的白内障手术初步研究/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
38卷
期数:
2018年1期
页码:
044-48
栏目:
应用研究
出版日期:
2018-01-05

文章信息/Info

Title:
Preliminary clinical research on liquid-immersion femtosecond laser assisted cataract surgery
作者:
王静; 赵江月; 陆璐; 肖宏; 张劲松
110005　辽宁省沈阳市，中国医科大学附属第四医院眼科，中国医科大学眼科医院，辽宁省晶状体学重点实验室
Author(s):
WANG Jing; ZHAO Jiang-Yue; LU Lu; XIAO Hong; ZHANG Jin-Song
Department of Ophthalmology，the Fourth Affiliated Hospital of China Medical University，Eye Hospital of China Medical University，the Key Lenticular Laboratory of Liaoning Province，Shenyang 110005，Liaoning Province，China
关键词:
飞秒激光; 白内障; 安全性; 有效性
Keywords:
femtosecond laser; cataract; safety; effectiveness
分类号:
R776.1
DOI:
10.13389/j.cnki.rao.2018.0009
文献标志码:
A
摘要:
目的　观察液体浸润式飞秒激光辅助的白内障手术（femtosecond laser assisted cataract surgery，FLACS）的临床安全性及有效性。方法　前瞻性研究。选择2013年10月至2014年4月间我院年龄相关性白内障患者70例（70眼），FLACS组35例，行液体浸润式LensAR FLACS，超声组35例，行常规白内障超声乳化吸出术。于术后1 d、1周、1个月及3个月对所有患者进行随访，记录裸眼视力（UCVA）、最佳矫正视力（BCVA）、结膜充血及睫状充血、角膜厚度、房水蛋白浓度及角膜内皮细胞计数等，并进行统计学分析。结果　FLACS组35例患者均顺利完成手术。FLACS组术中超声时间及超声能量分别为（23.25±7.21）s、7.91%±2.75%,均低于超声组的（34.08±8.59）s、16.95%±4.60%（均为P=0.000）。术后1 d及1周，FLACS组LogMAR 视力UCVA及BCVA、角膜厚度均较超声组低。术后1周、3个月，FLACS组角膜内皮细胞丢失率分别为9.63%±3.67%、11.22%±3.77%，均较超声组的13.29%±4.62%、15.16%±5.02%低，差异均有统计学意义（均为P=0.000）。术后1 d、1周、1个月，FLACS组房水蛋白浓度分别为（16.88±4.76）nc·s-1、（14.12±4.96）nc·s-1、(9.71±3.83)nc·s-1，均较超声组低（均为P<0.05）。术后1 d两组间结膜充血及睫状充血分级差异均无统计学意义（均为P>0.05）。结论　液体浸润式FLACS具有临床安全性及有效性，在减少眼部组织损伤，提高术后早期视力恢复方面具有一定的优势。
Abstract:
Objective　To observe the safety and effectiveness of liquid-immersion femtosecond laser assisted cataract surgery (FLACS).Methods　A prospective study was conducted in together 70 age-related cataract patients (70 eyes) between October 2013 and April 2014，and these subjects were randomly divided into two groups：FLACS group，35 patients undergoing liquid-immersion LensAR FLACS，and ultrasound group，35 patients receiving conventional phacoemulsification.All patients were followed up 1 day，1 week，1 month and 3 months after operation.The variables，including uncorrected distance visual acuity (UCVA)，best corrected distance visual acuity (BCVA)，redness analysis，corneal thickness，aqueous humor protein concentration and corneal endothelial cell count were recorded and analyzed.Results　All procedures in the FLACS group were successful.The ultrasound time and energy in the FLACS group were statistically less than those in the ultrasound group［(23.25±7.21)s,(7.91%±2.75%) vs.(34.08±8.59)s,(16.95%±4.60%)］ (both P=0.000).The LogMAR UCVA and LogMAR BCVA were better and the corneal thickness in FLACS group were statistically less than those in the ultrasound group postoperative 1 day and 1 week (all P<0.05).And the corneal endothelial cell loss rate in the FLACS group was statistically lower than that in the ultrasound group postoperative 1 week and 3 months［(9.63%±3.67%),(11.22%±3.77%) vs.(13.29%±4.62%),(15.16%±5.02%)］(all P=0.000).One day，1 week and 1 month after operation，the aqueous humor protein concentration in the FLACS group［（16.88±4.76）nc·s-1，（14.12±4.96）nc·s-1,(9.71±3.83)nc·s-1］ was lower than those in the ultrasound group (all P<0.05).However，there was no significant difference in conjunctival hyperemia and ciliary congestion between the two groups at 1 day after operation (all P>0.05).Conclusion　The liquid-immersion FLACS is efficient and safe for assisting cataract surgery that may have some advantages in reducing tissue damage and improving postoperative early visual recovery.

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备注/Memo

备注/Memo:
国家自然科学基金项目（编号：81470617）
更新日期/Last Update: 2018-01-22