[1]于莎莎,赵云.干细胞对视神经损伤的修复作用[J].眼科新进展,2018,38(3):298-300.[doi:10.13389/j.cnki.rao.2018.0070]
 YU Sha-Sha,ZHAO Yun.Latest progress in stem cell transplantation for the treatment of optic nerve injury[J].Recent Advances in Ophthalmology,2018,38(3):298-300.[doi:10.13389/j.cnki.rao.2018.0070]
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干细胞对视神经损伤的修复作用/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
38卷
期数:
2018年3期
页码:
298-300
栏目:
文献综述
出版日期:
2018-03-05

文章信息/Info

Title:
Latest progress in stem cell transplantation for the treatment of optic nerve injury
作者:
于莎莎赵云
300020 天津市,天津市眼科医院,天津市眼科学与视觉科学重点实验室,天津市眼科研究所,天津医科大学眼科临床学院
Author(s):
YU Sha-ShaZHAO Yun
Tianjin Eye Hospital,Tianjin Eye Institute,Clinical College of Ophthalmology of Tianjin Medical University,Tianjin Key Laboratory of Ophthalmology and Vision Science,300020 Tianjin,China
关键词:
干细胞神经营养因子视网膜神经节细胞
Keywords:
stem cellsneurotrophic factorsretinal ganglion cells
分类号:
R774
DOI:
10.13389/j.cnki.rao.2018.0070
文献标志码:
A
摘要:
视网膜神经节细胞损伤或死亡往往会导致视功能不可逆性损害。目前尚无有效的治疗方法修复损伤的视神经,恢复受损的视功能。干细胞具有多向分化潜能,其在视神经保护及损伤修复中的作用日渐成为研究热点。本文旨在对干细胞在视神经损伤修复基础和临床研究方面的进展进行综述。
Abstract:
Injury or death of retinal ganglion cells may lead to irreversibly damage to visual function.However,no treatment have showed efficiency to replace the damaged cells and restore the visual function.Due to the multi-directionally differentiated potential of stem cells,their role in optic nerve protection and restoration following injury is becoming a hot research spot.The purpose of this article is to summarize the progress of stem cells for the repair of optic nerve in basic and clinical researches.

参考文献/References:

[1] YU SS,TANG X,HO YS,CHANG RC,CHIU K.Links between the brain and retina:the effects of cigarette smoking-induced age-related changes in alzheimer’s disease and macular degeneration[J].Front Neurol,2016,27(7):119.
[2] ZHOU YS,XU J,PENG J,LI P,WEN XJ,LIU Y,et al.Research progress of stem cells on glaucomatous optic nerve injury[J].Int J Ophthalmol,2016,9(8):1226-1229.
[3] YUWAIMAN P,WOTRUBA M,BURTE F,LA MORGIA C,BARBONI P,CARELLI V.A neurodegenerative perspective on mitochondrial optic neuropathies[J].Acta Neuropathol,2016,132(6):789-806.
[4] FISCHER D,LEIBINGER M.Promoting optic nerve regeneration[J].Prog Retin Eye Res,2012,31 (6):688-701.
[5] KUMARAN AM,SUNDAR G,CHYE LT.Traumatic optic neuropathy:a review[J].Caraniomaxillofac Trauma Reconstr,2015,8(1):31-41.
[6] GARG A,YANG J,LEE W,TSANG SH.Stem cell therapies in retinal disorders[J].Cells,2017,6(1):E4.
[7] LABRADOR-VELANDIA S,ALONSO-ALONSO ML,ALVAREZS-ANCHEZ S,GONZALEZ-ZAMORA J,CARRETERO-BARRIO I,PASTOR JC,et al.Mesenchymal stem cell therapy in retinal and optic nerve diseases:an update of clinical trials[J].World J Stem Cells,2016,8(11):376-383.
[8] MASHKOURI S,CROWLEY MG,LISKA MG,COREY S,BORLONGAN CV.Utilizing pharmacotherapy and mesenchymal stem cell therapy to reduce inflammation following traumatic brain injury[J].Neural Regen Res,2016,11(9):1379-1384.
[9] WAKAO S,MATSUSE D,DEZAWA M.Mesenchymal stem cells as a source of Schwann cells:their anticipated use in peripheral nerve regeneration[J].Cells Tissues Organs,2014,200(1):31-41.
[10] CHUNG S,RHO S,KIM G,KIM SR,BAEK KH,KANG M,et al.Human umbilical cord blood mononuclear cells and chorionic plate-derived mesenchymal stem cells promote axon survival in rat model of optic nerve crush injury[J].Int J Mol Med,2016,37(5):1170-1180.
[11] CHEN M,XIANG Z,CAI J.The anti-apoptotic and neuro-protective effects of human umbilical cord blood mesenchymal stem cell (hUCB-MSCs) on acute optic nerve injury is transient[J].Brain Res,2013,1532:63-75.
[12] TAN H,KANG X,LU S,LIU L.The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat[J].Clin Interv Aging,2015,16(10):487-490.
[13] JUNYI L,NA L,YAN J.Mesenchymal stem cells secrete brain-derived neurotrophic factor and promote retinal ganglion cell survival after traumatic optic neuropathy[J].J Craniofac Surg,2015,26(2):548-552.
[14] YUAN J,YU JX.Gender difference in the neuroprotective effect of rat bone marrow mesenchymal cells against hypoxia-induced apoptosis of retinal ganglion cells[J].Neural Regen Res,2016,11(5):846-853.
[15] ZHAO YJ,PANG L,YOU ZP.Advance in methods of induced-embryonic stem cell differentiation to retinal cells[J].Chin J Exp Ophthalmol,2016,34(9):851-854.
赵永吉,庞丽,游志鹏.胚胎干细胞诱导分化视网膜细胞的方法新进展[J].中华实验眼科杂志,2016,34(9):851-854.
[16] SHROFF G,THAKUR D,DHINGRA V,BAROLI DS,KHATRI D,GAUTAM RD.Role of physiotherapy in the mobilization of patients with spinal cord injury undergoing human embryonic stem cells transplantation[J].Clin Transl Med,2016,5(1):41.
[17] SLUCH VW,DAVIS CH,RANGANATHAN V,KERR JM,KRICK K,MARTIN R,et al.Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reported cell line[J].Sci Rep,2015,13(5):16595.
[18] SPARPE PT.Dental mesenchymal stem cells[J].Development,2016,143(13):2273-2280.
[19] MEAD B,LOGAN A,BERRY M,LEADBEATER W,SCHEVEN BA.Concise review:dental pulp stem cells:a novel cell therapy for retinal and central nervous system repair[J].Stem Cells,2017,35(1):61-67.
[20] MEAD B,LOGAN A,BERRY M,LEADEATER W,SCHEVEN BA.Intravitreally transplanted dental pulp stem cells promote neuroprotection and axon regeneration of retinal ganglion cells after optic nerve injury[J].Invest Ophthalmol Vis Sci,2013,54(12):7544-7556.
[21] HUNG SS,KHAN S,LO CY,HEWITT AW,WONG RC.Drug discovery using induced pluripotent stem cell models of neurodegenerative and ocular diseases[J].Pharmacol Ther,2017,177:32-43.
[22] TAKAHASHI K,YAMANAKA S.Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors[J].Cell,2006,126(4):663-676.
[23] SATARIAN L,JAVAN M,KIANI S,HAJIKARAM M,MIRNAJAFI-ZADEH J,BAHARVAND H.Engrafted human induced pluripotent stem cell-derived anterior specified neural progenitors pretect the rat crushed optic nerve[J].PLoS One,2013,8(8):e71855.
[24] ROURA S,PUJAL JM,GALVEZ-MONTON C,BAYES-GENIS A.The role and potential of umbilical cord blood in an era of new therapies:a review[J].Stem Cell Res Ther,2015,6:123.
[25] JIANG B,ZHANG P,ZHOU D,ZHANG J,XU X,TANG L.Intravitreal transplantation of human umbilical cord blood stem cells protects rats from traumatic optic neuropathy[J].PLoS One,2013,8(8):e69938.
[26] ZHAO T,LI Y,TANG L,LI Y,FAN F,JIANG B.Protective effects of human umbilical cord blood stem cell intravitreal transplantation against optic nerve injury in rats[J].Graefes Arch Clin Exp Ophthalmol,2011,249(7):1021-1028.

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更新日期/Last Update: 2018-03-05