[1]王霞,刘瀛,刘旭,等.诱导多功能干细胞在青光眼治疗中的应用研究进展[J].眼科新进展,2017,37(12):1185-1188.[doi:10.13389/j.cnki.rao.2017.0299]
　WANG Xia,LIU Ying,LIU Xu,et al.Recent advances of induced pluripotent stem cells in glaucoma treatment[J].Recent Advances in Ophthalmology,2017,37(12):1185-1188.[doi:10.13389/j.cnki.rao.2017.0299]
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
37卷
期数:
2017年12期
页码:
1185-1188
栏目:
文献综述
出版日期:
2017-12-05

文章信息/Info

Title:
Recent advances of induced pluripotent stem cells in glaucoma treatment
作者:
王霞; 刘瀛; 刘旭; 何媛
710068　陕西省西安市，西安医学院（王霞）；710038　陕西省西安市，西安医学院第二附属医院眼科（王霞，刘瀛，刘旭，何媛）
Author(s):
WANG Xia; LIU Ying; LIU Xu; HE Yuan
Xi’an Medical College（WANG Xia），Xi’an 710068，Shaanxi Province，China；Department of Ophthalmology，the Second Affiliated Hospital of Xi’an Medical College（WANG Xia，LIU Ying，LIU Xu，HE Yuan），Xi’an 710038，Shaanxi Province，China
关键词:
青光眼; 视网膜神经节细胞; 干细胞; 诱导多功能干细胞
Keywords:
glaucoma; retinal ganglion cells; stem cells; induced pluripotent stem cells
分类号:
R775
DOI:
10.13389/j.cnki.rao.2017.0299
文献标志码:
A
摘要:
青光眼是一组以视神经萎缩和视野缺损为共同特征的疾病，青光眼和其他视神经疾病导致的视网膜神经节细胞（retinal ganglion cells，RGCs）损伤和死亡是引起不可逆的视觉丢失或致盲的一个主要原因。诱导多功能干细胞衍生来的RGCs能够为青光眼提供一种新的细胞治疗法。并且，这些细胞能够在人类RGCs的研究进展、基因调控、神经生物学研究中开拓一个新的视野。本文就诱导多功能干细胞衍生的不同类型细胞在青光眼细胞替代治疗等方面的最新研究和应用进展作一综述，以探讨其临床应用前景。
Abstract:
Glaucoma is a disease characterized by optic atrophy and visual field defects.Injury and death of retinal ganglion cells （RGCs） caused by glaucoma and other optic neuropathy are one of the main causes of irreversible visual loss or blindness.RGCs，which are derived from induced pluripotent stem cells，can provide a new cell alternative therapy for glaucoma and a promising prospect for a new field in the research progress，gene regulation and neurobiology of human RGCs.Therefore，this article will give an insight into the latest researches and application progress of different types of cells derived from induced pluripotent stem cells in glaucoma and discuss the clinical application prospects.

参考文献/References:

［1］　BROMAN HA.The number of people with glaucoma worldwide in 2010 and 2020［J］.Digest World Core Med J，2006，90（3）：262-267.
［2］　KUEHN MH，FINGERT JH，KWON YH.Retinal ganglion cell death in glaucoma：mechanisms and neuroprotective strategies［J］.Ophthalmol Clin North Am，2005，18（3）：383-395.
［3］　GUPTA N，YüCEL YH.Glaucoma as a neurodegenerative disease［J］.Curr Opin Ophthalmol，2007，18（2）：110.
［4］　SHIELDS M.Normal-tension glaucoma：is it different from primary open-angle glaucoma［J］?Curr Opin Ophthalmol，2008，19（2）：85-88.
［5］　MUCH JW，LIU C，PILTZ JR.Long-term survival of central visual field in end-stage glaucoma［J］.Ophthalmology，2008，115（7）：1162-1166.
［6］　孙颖健，郑雅娟.干细胞移植治疗视网膜神经节细胞损伤性疾病的研究进展［J］.国际眼科杂志，2015，15（4）：630-632.
SUN YJ，ZHENG YJ.Progress in stem cell transplantation for treatment of retinal ganglion cell damage diseases［J］.Int Eye Sci，2015，15（4）：630-632.
［7］　JOHNSON TV，MARTIN KR.Cell transplantation approaches to retinal ganglion cell neuroprotection in glaucoma［J］.Curr Opin Pharmacol，2013，13（1）：78-82.
［8］　MEYER-RUSENBERG B，PAVLIDIS M，STUPP T，THANOS S.Pathological changes in human retinal ganglion cells associated with diabetic and hypertensive retinopathy［J］.Graefes Arch Clin Exp Ophthalmol，2006，245（7）：1009-1018.
［9］　CHADER GJ，YOUNG M.Preface：Sight restoration through stem cell therapy［J］.Invest Ophthalmol Vis Sci，2016，57（5）：ORSFa1-5.
［10］　REUBINOFF BE，PERA MF，FONG CY，TROUNSON A，BONGSO A.Embryonic stem cell lines from human blastocysts：somatic differentiation in vitro［J］.Nat Biotechnol，2000，18（4）：399-404.
［11］　KLIMANSKAYA I，CHUNG Y，BECKER S，LU SJ，LANZA R.Human embryonic stem cell lines derived from single blastomeres［J］.Nature，2006，444（7118）：481-485.
［12］　MATSUI Y，TOKSOZ D，NISHIKAWA S，NISHIKAWA S，WILLIAMS D，ZSEBO K，et al.Effect of steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture［J］.Nature，1991，353（6346）：750-752.
［13］　LAMBA DA，KARL MO，WARE CB，REH TA.Efficient generation of retinal progenitor cells from human embryonic stem cells［J］.Proc Natl Acad Sci，2006，103（34）：12769-71274.
［14］　TAKAHASHI KS，AMANAKA Y.Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors［J］.Cell，2006，126（4）：663-676.
［15］　TAKAHASHI K，TANABE K，OHNUKI M，NARITA M，ICHISAKA T，TOMODA K，et al.Induction of pluripotent stem cells from adult human fibroblasts by defined factors［J］.Cell，2007，131（5）：861-872.
［16］　LIANG P，LAN F，LEE AS，GONG T，SANCHEZ-FREIRE V，WANG Y，et al.Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity［J］.Circulation，2013，127（16）：1677-1691.
［17］　SINHA D，PHILLIPS J，JOSEPH PM，GAMM DM.Mimicking retinal development and disease with human pluripotent stem cells［J］.Invest Ophthalmol Vis Sci，2016，57（5）：ORSFf1-9.
［18］　GARG A，YANG J，LEE W，TSANG SH.Stem cell therapies in retinal disorders［J］.Cells，2017，6（1）.
［19］　KAEWKHAW R，SWAROOP M，HOMMA K，NAKAMURA J，Brooks M，Kaya KD，et al.Treatment paradigms for retinal and macular diseases using 3-d retina cultures derived from human reporter pluripotent stem cell lines［J］.Invest Ophthalmol Vis Sci，2016，57（5）：ORSFl1-11.
［20］　DI FV，MAKWANA P，ALI RR，SOWDEN JC.Induced pluripotent stem cell therapies for degenerative disease of the outer retina：Disease modeling and cell replacement［J］.J Ocul Pharmacol Ther，2016，32（5）：240-252.
［21］　CHAMLING X，SLUCH VM，ZACK DJ.The potential of human stem cells for the study and treatment of glaucoma［J］.Invest Ophthalmol Vis Sci，2016，57（5）：ORSFi1-6.
［22］　ZWI-DANTSIS L，GEPSTEIN L.Induced pluripotent stem cells for cardiac repair［J］.Cell Mol Life Sci，2012，69（19）：3285-3299.
［23］　KHAN S，HUNG SS，WONG RC.The use of induced pluripotent stem cells for studying and treating optic neuropathies［J］.Curr Opin Organ Transplant，2016，21（5）：484-489.
［24］　REICHMAN S，GOUREAU O.Production of retinal cells from confluent human iPS cells［J］.Methods Mol Biol，2016，1357：339-351.
［25］　PARAMESWARAN S，BALASUBRAMANIAN S，BABAI N，QIU F，EUDY JD，THORESON WB，et al.Induced pluripotent stem cells generate both retinal ganglion cells and photoreceptors：therapeutic implications in degenerative changes in glaucoma and age-related macular degeneration［J］.Stem Cells，2010，28（4）：695-703.
［26］　CHEN M，CHEN Q，SUN X，SHEN W，LIU B，ZHONG X，et al.Generation of retinal ganglion-like cells from reprogrammed mouse fibroblasts［J］.Invest Ophthalmol Vis Sci，2010，51（51）：5970-5978.
［27］　RIAZIFAR H，JIA Y，CHEN J，LYNCH G，HUANG T.Chemically-induced specification of retinal ganglion cells from human embryonic and induced pluripotent stem cells［J］.Stem Cells Transl Med，2014，3（4）：424-432.
［28］　许卓珺，余克明，庄菁.诱导多能干细胞向神经视网膜细胞定向分化的研究进展［J］.眼科新进展，2016，36（9）：885-888.
XU ZJ，YU KM，ZHUANG J.Research progress on differentiation from induced pluripotent stem cells into neural retinal cells［J］.Rec Adv Ophthalmol，2016，36（9）：885-888.
［29］　TANAKA T，YOKOI T，TAMALU F，WATANABE S，NISHINA S，AZUMA N.Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells［J］.Sci Rep，2015，5（7）：8344.
［30］　PARAMESWARAN S，DRAVID SM，TEOTIA P，KRISHNAMOORTHY RR，QIU F，TORIS C，et al.Continuous non-cell autonomous reprogramming to generate retinal ganglion cells for glaucomatous neuropathy［J］.Stem Cells，2015，33（6）：1743-1758.
［31］　DENG F，CHEN M，LIU Y，HU H，XIONG Y，XU C，et al.Stage-specific differentiation of iPSCs toward retinal ganglion cell lineage［J］.Mol Vis，2016，22：536-547.
［32］　KAMAO H，MANDAI M，OHASHI W，HIRAMI Y，KURIMOTO Y，KIRYU J，et al.Evaluation of the surgical device and procedure for extracellular matrix-scaffold-supported human ipsc-derived retinal pigment epithelium cell sheet transplantation［J］.Invest Ophthalmol Vis Sci，2017，58（1）：211.
［33］　KADOR KE，ALSEHLI HS，ZINDELL AN，LAU LW，ANDREOPOULOS FM，WATSON BD，et al.Retinal ganglion cell polarization using immobilized guidance cues on a tissue-engineered scaffold［J］.Acta Biomaterialia，2014，10（12）：4939-4946.
［34］　ZHONG X，GUTIERREZ C，XUE T，HAMPTON C，VERGARA MN，CAO LH，et al.Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs［J］.Nat Commun，2014，5：4047.
［35］　MEYER JS，HOWDEN SE，WALLACE KA，VERHOEVEN AD，WRIGHT LS，CAPOWSKI EE，et al.Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment［J］.Stem Cells，2011，29（8）：1206-1218.
［36］　NAKANO T，ANDO S，TAKATA N，KAWADA M，MUGURUMA K，SEKIGUCHI K，et al.Self-Formation of optic cups and storable stratified neural retina from human ESCs［J］.Cell Stem Cell，2012，10（6）：771.
［37］　EIRAKU M，TAKATA N，ISHIBASHI H，KAWADA M，SAKAKURA E，OKUDA S，et al.Self-organizing optic-cup morphogenesis in three-dimensional culture［J］.Nature，2011，472（7341）：51-56.
［38］　XIE BB，ZHANG XM，HASHIMOTO T，TIEN AH，CHEN A，GE J，et al.Differentiation of retinal ganglion cells and photoreceptor precursors from mouse induced pluripotent stem cells carrying an Atoh7/Math5 lineage reporter［J］.PLoS One，2014，9（11）：e112175.
［39］　GILL KP，HEWITT AW，DAVIDSON KC，PEBAY A，WONG RC.Methods of retinal ganglion cell differentiation from pluripotent stem cells［J］.Transl Vis Sci Technol，2014，3（4）：7.
［40］　SLUCH VM，DAVIS CHO，RANGANATHAN V，KERR JM，KRICK K，MARTIN R，et al.Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line［J］.Sci Rep，2015，5：16595.
［41］　OHLEMACHER SK，SRIDHAR A，XIAO Y，HOCHSTETLER AE，SARFARAZI M，CUMMINS TR，et al.Stepwise differentiation of retinal ganglion cells from human pluripotent stem cells enables analysis of glaucomatous neurodegeneration［J］.Stem Cells，2016，34（6）：1553-1562.
［42］　AUNG T，REZAIE T，OKADA K，VISWANATHAN AC，CHILD AH，BRICE G，et al.Clinical features and course of patients with glaucoma with the E50K mutation in the optineurin gene［J］.Invest Ophthalmol Vis Sci，2005，46（8）：2816.
［43］　ALMEIDA RD，MANADAS BJ，MELO CV，GOMES JR，MENDES CS，GRAOS MM，et al.Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways［J］.Cell Death Differ，2005，12（10）：1329-1343.
［44］　TOMBRAN-TINK J，BARNSTABLE CJ.Therapeutic prospects for PEDF：more than a promising angiogenesis inhibitor［J］.Trends Mol Med，2003，9（9）：244-250.
［45］　HAMBRIGHT D，PARK KY，BROOKS M，MCKAY R，SWAR-OOP A，NASONKIN IO.Long-term survival and differentiation of retinal neurons derived from human embryonic stem cell lines in un-immunosuppressed mouse retina［J］.Mol Vis，2012，18（96-97）：920.
［46］　SATARIAN L，JAVAN M，KIANI S，HAJIKARAM M，MIRNAJAFI-ZADEH J，BAHARVAND H.Engrafted human induced pluripotent stem cell-derived anterior specified neural progenitors protect the rat crushed optic nerve［J］.PLoS One，2013，8（8）：e71855.
［47］　LUTJEN-DRECOLL E，GABELT BT，TIAN B，KAUFMAN PL.Outflow of aqueous humor［J］.J Glaucoma，2001，10（1）：42-44.
［48］　ABU-HASSAN DW，LI X，RYAN EI，ACOTT TS，KELLEY MJ.Induced pluripotent stem cells restore function in a human cell loss model of open-angle glaucoma［J］.Stem Cells，2015，33（3）：751-761.
［49］　DING QJ，ZHU W，COOK AC，ANFINSON KR，TUCKER BA，KUEHN MH.Induction of trabecular meshwork cells from induced pluripotent stem cells［J］.Invest Ophthalmol Vis Sci，2014，55（11）：7065-7072.
［50］　ZHU W，GRAMLICHA OW，LABOISSONNIEREC L，JAIND A，SHEFFIELDA VC，TRIMARCHIC JM，et al.Transplantation of iPSC-derived TM cells rescues glaucoma phenotypes in vivo［J］.Proc Natl Acad Sci USA，2016，113（25）：3492-3500.

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备注/Memo

备注/Memo:
国家自然科学基金资助（编号：81100665）
更新日期/Last Update: 2017-12-08