[1]马晓敏,刘丹.视网膜静脉阻塞患者血小板参数及同型半胱氨酸水平的临床分析[J].眼科新进展,2017,37(10):973-975.[doi:10.13389/j.cnki.rao.2017.0247]
　MA Xiao-Min,LIU Dan.Clinical analysis of platelet parameters and homocysteine in patients with retinal vein occlusion[J].Recent Advances in Ophthalmology,2017,37(10):973-975.[doi:10.13389/j.cnki.rao.2017.0247]
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视网膜静脉阻塞患者血小板参数及同型半胱氨酸水平的临床分析/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
37卷
期数:
2017年10期
页码:
973-975
栏目:
应用研究
出版日期:
2017-10-05

文章信息/Info

Title:
Clinical analysis of platelet parameters and homocysteine in patients with retinal vein occlusion
作者:
马晓敏; 刘丹
121001　辽宁省锦州市，锦州医科大学（马晓敏）；121001　辽宁省锦州市，锦州医科大学附属第一医院眼科（刘丹）
Author(s):
MA Xiao-Min; LIU Dan
Jinzhou Medical University（MA Xiao-Min），Jinzhou 121001，Liaoning Province，China；Department of Ophthalmology，the First Affiliated Hospital of Jinzhou Medical University（LIU Dan），Jinzhou 121001，Liaoning Province，China
关键词:
视网膜静脉阻塞; 血小板计数; 血小板平均体积; 同型半胱氨酸
Keywords:
retinal vein occlusion; platelet count; mean platelet volume; homocysteine
分类号:
R774
DOI:
10.13389/j.cnki.rao.2017.0247
文献标志码:
A
摘要:
目的　检测视网膜静脉阻塞（retinal vein occlusion，RVO）患者的同型半胱氨酸（homocysteine，Hcy）水平和血小板参数，包括血小板计数（platelet，PLT）、血小板平均体积（mean platelet volume，MPV），探讨两者是否作为致病因素参与RVO发病。方法　对临床诊断为RVO的48例患者（RVO组）进行血PLT、MPV、Hcy测定，包括视网膜分支静脉阻塞（branch retinal vein occlusion，BRVO）患者22例（BRVO组）和视网膜中央静脉阻塞（central retinal vein occlusion，CRVO）患者26例（CRVO组），并与临床诊断为白内障的40例对照组进行比较并作统计学分析。结果　RVO组PLT水平（212.99±50.10）×109 L-1，与对照组PLT水平（198.11±44.69）×109 L-1比较，差异无统计学意义（P＞0.05），RVO组MPV与Hcy水平（9.44±0.97）fL、（8.99±0.81）μmol·L-1较对照组（8.66±0.96）fL和（8.38±0.62）μmol·L-1均增高（均为P＜0.05）。PLT水平在CRVO组（212.27±49.07）×109 L-1、BRVO组（213.84±52.43）×109 L-1及对照组间比较差异均无统计学意义（均为P＞0.05），MPV、Hcy水平在CRVO组（9.48±0.91）fL、（8.97±0.76）μmol·L-1与BRVO组（9.40±1.06）fL、（9.01±0.89）μmol·L-1，较对照组均增高（均为P＜0.05），但在CRVO组与BRVO组间比较差异均无统计学意义（均为P＞0.05）。结论　高MPV、高Hcy可能是引起RVO发病的危险因素，降血小板及降Hcy的治疗从理论上讲是一种积极有效的预防措施。
Abstract:
Objective　To detect the homocysteine (Hcy) level and platelet parameters in patients with retinal vein occlusion (RVO) and to investigate the correlation of above variables with RVO.Methods　Measurement of platelet (PLT)，mean platelet volume (MPV) and Hcy were performed in 48 patients with clinical diagnosis of RVO，including 22 patients with branch retinal vein occlusion (BRVO) and 26 patients with central retinal vein occlusion (CRVO)，while another 40 patients with cataract were collected as controls，and all clinical data were compared and analyzed statistically in all subjects.Results　The difference in the level of PLT in RVO group (212.99±50.10)×109·L-1 and the control group (198.11±44.69)×109·L-1 has no statistical significance(P>0.05)，and RVO group had higher levels of MPV and Hcy (9.44±0.97)fL and (8.99±0.801)μmol·L-1 than the control group (8.66±0.96) fL and (8.38±0.623)μmol·L-1(P<0.05).Furthermore，there was no significant difference in the level of PLT in CRVO group (212.27±49.07)×109 L-1，BRVO group (213.84±52.43)×109 L-1 and the control group (all P>0.05).The levels of MPV and Hcy in CRVO group (9.48±0.91)fL and (8.97±0.76)μmol·L-1 and BRVO group (9.40±1.06)fL and (9.01±0.89)μmol·L-1 were higher than those in the control group (all P<0.05)，but there was no significant difference between CRVO group and BRVO group (P>0.05).Conclusion High MPV and high Hcy may be the risk factors，which can lead to RVO，and it is a positive and effective method of attenuating platelet and Hcy levels to treat RVO.

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更新日期/Last Update: 2017-10-24