[1]罗丹,温跃春,季青山.小梁切除术分别联合Ologen植入与丝裂霉素C治疗青光眼的有效性和安全性对比分析[J].眼科新进展,2016,36(2):175-177.[doi:10.13389/j.cnki.rao.2016.0048]
　LUO Dan,WEN Yue-Chun,JI Qing-Shan.Comparison of efficacy and safety between trabeculectomy with Ologen implant and mitomycin C:A Meta-analysis[J].Recent Advances in Ophthalmology,2016,36(2):175-177.[doi:10.13389/j.cnki.rao.2016.0048]
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小梁切除术分别联合Ologen植入与丝裂霉素C治疗青光眼的有效性和安全性对比分析
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年2期
页码:
175-177
栏目:
应用研究
出版日期:
2016-02-05

文章信息/Info

Title:
Comparison of efficacy and safety between trabeculectomy with Ologen implant and mitomycin C:A Meta-analysis
作者:
罗丹; 温跃春; 季青山
230001　安徽省合肥市，安徽医科大学附属安徽省立医院眼科
Author(s):
LUO Dan; WEN Yue-Chun; JI Qing-Shan
Department of Ophthalmology , the Affiliated Anhui Provincial Hospital of Anhui Medical University , Hefei 230001 .Anhui Province , China
关键词:
小梁切除术; 青光眼; Ologen植入; 丝裂霉素C; Meta分析
Keywords:
trabeculectomy ;  glaucoma ;  Ologen implant ;  mitomycin C ;  Meta-analysis
DOI:
10.13389/j.cnki.rao.2016.0048
文献标志码:
A
摘要:
目的　对比分析小梁切除术分别联合Ｏｌｏｇｅｎ植入与丝裂霉素Ｃ（ｍｉｔｏｍｙｃｉｎＣ，ＭＭＣ）治疗青光眼的有效性和安全性。方法　利用计算机检索Ｍｅｄｌｉｎｅ、ＥＭＢＡＳＥ、ＷｅｂｏｆＳｃｉｅｎｃｅ、ＣｏｃｈｒａｎｅＣｅｎｔｒａｌｏｆＣｏｎｔｒｏｌｌｅｄＴｒｉａｌｓ、ＧｏｏｇｌｅＳｃｈｏｌａｒ等数据库，检索时间均从建库至２０１４年１月，并追溯纳入文献的参考文献。将获得的临床对照研究，通过纳入和排除标准限定，经质量评价后，采用ＲｅｖＭａｎ５．０软件进行Ｍｅｔａ分析。结果　纳入６篇临床对照研究（小梁切除术联合Ｏｌｏｇｅｎ植入组１１４例，小梁切除术联合ＭＭＣ组１２３例），质量评分均大于１６分，为高质量文献。Ｍｅｔａ分析结果显示，Ｏｌｏｇｅｎ植入组术后患者眼压减低，但眼压降低百分率与ＭＭＣ治疗组相比无明显差异。两组在青光眼药物种数治疗减少、手术成功率及术后并发症发生率等方面亦无明显差异。结论　小梁切除术联合Ｏｌｏｇｅｎ植入治疗青光眼在长期眼压控制成功率方面与小梁切除术联合ＭＭＣ治疗效果相当，在避免ＭＭＣ治疗引发的术后并发症方面无明显优势。
Abstract:
Objective To systematically compare the efficacy and safety of trabeculectomy with Ologen implant and mitomycin C ( MMC) for glaucoma. Methods Such databases as Medline , EMBASE . Web of Science , Cochrane Central of Controlled Trials , Google Scholar were searched until January 2014 , also the references of included studies were traced. The controlled trials on trabeculectomy + Ologen vs. trabeculectomy + MMC for glaucoma after study selections were scored highly by Downs and Blacks score. Then meta-analysis was performed using RevMan 5. 0 software. Results Six studies involved 114 eyes on trabeculectomy + Ologen and 123 eyes on trabeculectomy + MMC were included in our study. Each study had a score > 16 points. The results of meta-analysis showed that Ologen implant was associated with a numerically low IOP , but no significant percentage reduction in IOP compared with MMC. There was no significant difference in the reduction of glaucoma medications . success rate . and incidence of complications. Conclusion Trabeculectomy with Ologen implant is comparable to the use of MMC with a similar long-term success rate. However.it does not seem to offer significant advantages of avoiding the potential complications related to MMC.

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更新日期/Last Update: 2016-01-29