[1]沙芳,丁美华,叶翔,等. 电针对透镜诱导性近视豚鼠闪光视网膜电图的影响[J].眼科新进展,2015,35(2):104-108.[doi:10.13389/j.cnki.rao.2015.0028]
　SHA Fang,DING Mei-Hua,YE Xiang,et al. Effects of electroacupuncture on flash electroretinogram of guinea pigs with lens-induced myopia[J].Recent Advances in Ophthalmology,2015,35(2):104-108.[doi:10.13389/j.cnki.rao.2015.0028]
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 电针对透镜诱导性近视豚鼠闪光视网膜电图的影响
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年2期
页码:
104-108
栏目:
实验研究
出版日期:
2015-02-05

文章信息/Info

Title:
 Effects of electroacupuncture on flash electroretinogram of guinea pigs with lens-induced myopia
作者:
 沙芳; 丁美华; 叶翔; 吴建峰; 毕爱玲; 张瑾; 毕宏生
 250014　山东省济南市，山东中医药大学
Author(s):
 SHA Fang;  DING Mei-Hua;  YE Xiang;  WU Jian-Feng;  BI Ai-Ling;  ZHANG Jin ;  BI Hong-Sheng
 Shandong University of Traditional Chinese Medicine , Jinan 250014 , Shandong Province , China
关键词:
 ; 电针; 透镜诱导性近视; 视网膜电图; 豚鼠
Keywords:
 ; electroacupuncture ;  lens-induced myopia;  electroretinogram ;  guinea pig
DOI:
10.13389/j.cnki.rao.2015.0028
文献标志码:
A
摘要:
 目的　探讨电针对透镜诱导性近视豚鼠闪光视网膜电图（ｅｌｅｃｔｒｏｒｅｔｉｎｏｇｒａｍ，ＥＲＧ）的影响。方法　２４只３周龄健康三色短毛豚鼠随机分为透镜诱导组（１２只）与透镜诱导＋电针组（１２只）。两组豚鼠右眼戴－１０Ｄ透镜，左眼不戴镜作为自身对照。透镜诱导＋电针组在戴镜的同时，电针刺激豚鼠两侧合谷穴与太阳穴。４周后测量２组屈光度、眼轴长度及ＥＲＧ波形的变化。结果　４周后，与自身对照眼比较，透镜诱导眼近视屈光度增加（Ｐ＜０．０１），眼轴延长（Ｐ＜０．０１）；同时其暗适应振荡电位的ＯＳ２波振幅及总振幅下降（均为Ｐ＜０．０１），暗适应最大混合反应、明适应视锥细胞反应的ｂ波振幅下降（均为Ｐ＜０.０１）。电针干预后，透镜诱导眼的屈光度和眼轴长度没有变化（Ｐ＞０．０５）；但与透镜诱导组右眼相比，透镜诱导＋电针组透镜诱导眼暗适应振荡电位的ＯＳ２波振幅及总振幅，暗适应最大混合反应、明适应视锥细胞反应的ｂ波振幅均增高（均为Ｐ＜０．０５），达到与其自身对照眼相似的水平（均为Ｐ＞０．０５）。结论　电针刺激合谷穴与太阳穴影响透镜诱导性近视豚鼠ＥＲＧ，可使其恢复至正常水平。
Abstract:
 Objective To explore the effects of electroacupuncture on flash electroretinogram ( ERG) of guinea pigs with lens-induced myopia. Methods Twenty-four healthy three-week-old guinea pigs were randomly divided into lens-induced group ( 12 cases ) and lens-induced + electroacupuncture group ( 12 cases ) . The right eyes of all animals were covered with - 10 D lenses and the left eyes were served as the self-control eyes. At the same time, all animals of lens-induced + electroacupuncture group were treated by the electroacupuncture stimulation at Hegu and Taiyang acupoints. The refraction , axial length and ERG were observed after 4 weeks. Results After 4 weeks. compared with self-control eyes, the myopic diopters of lens-induced eyes were increased ( P < 0. 01 ) and the axial length of those were longer (P < 0. 01 ) ; Meanwhile . decrease of the amplitude of OS2 wave and total wave of oscillatory potentials .b-wave of Max-ERG and Cone-ERG were observed in the lens-induced eyes ( all P < 0. 01) . There was no obvious difference between electroacupuncture treatment and non-electroacupuncture treatment in myopic diopter and axial length of the lens-induced eyes ( all P > 0. 05 ) . However , compared with the right eyes of lens-induced group , the amplitude of OS7 wave and total wave of OPs ,b-wave of Max-ERG and Cone-ERG were significantly increased in lens-induced eyes with electroacupuncture treatment ( all P < 0. 05 ) .which reached to the levels similar to those of self-control eyes ( all P > 0. 05 ) . Conclusion ERG of the guinea pigs with lens-induced myopia is affected by electroacupuncture stimulation at Hegu and Taiyang acupoints , and is recovered to a normal level.

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备注/Memo

备注/Memo:
 国家自然科学基金资助（编号：８１１７３４４０、８１３０３０３１）；山东省科技发展计划（编号：２０１３ＧＳＦ１１８５７、２０１１ＧＳＦ１１８４１、２０１１ＧＧＢ１４０９７）；山东省医药卫生科技发展计划（编号：２０１１ＨＤ０１４）
更新日期/Last Update: 2015-02-03