[1]王坤,万光明,徐亚娟,等.糖尿病合并高度近视患者玻璃体中VEGF和EPO的表达及意义[J].眼科新进展,2014,34(5):445-447.[doi:10.13389/j.cnki.rao.2014.0121]
　WANG Kun,WAN Guang-Ming,XU Ya-Juan,et al.Expression and significance of VEGF and EPO in vitreous body of diabetes mellitus with high myopia[J].Recent Advances in Ophthalmology,2014,34(5):445-447.[doi:10.13389/j.cnki.rao.2014.0121]
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糖尿病合并高度近视患者玻璃体中VEGF和EPO的表达及意义
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
34卷
期数:
2014年5期
页码:
445-447
栏目:
应用研究
出版日期:
2014-05-05

文章信息/Info

Title:
Expression and significance of VEGF and EPO in vitreous body of diabetes mellitus with high myopia
作者:
王坤; 万光明; 徐亚娟; 梁申芝
４５００５２　河南省郑州市， 郑州大学第一附属医院眼科
Author(s):
WANG Kun ;  WAN Guang-Ming ; XU Ya-Juan ;  LIANG Shen-Zh
关键词:
糖尿病视网膜病变; 高度近视; 玻璃体; 血管内皮生长因子; 促红细胞生成素
Keywords:
diabetic retinopathy ;  high myopia ;  vitreous body ;  vascular endothelial growth factor ;  erythropoietin
DOI:
10.13389/j.cnki.rao.2014.0121
文献标志码:
A
摘要:
目的　通过检测高度近视合并糖尿病患者玻璃体中血管内皮生长因子（ｖａｓｃｕｌａｒｅｎｄｏｔｈｅｉａｌｇｒｏｗｔｈｆａｃｔｏｒ，ＶＥＧＦ）和促红细胞生成素（ｅｒｙｔｈｒｏｐｏｉｅｔｉｎ，ＥＰＯ）的浓度，探讨高度近视对糖尿病视网膜病变的影响。方法　选取待行玻璃体手术的视网膜脱离患者６２例（６２眼），其中对照组１８眼，高度近视组１６眼，增生型糖尿病视网膜病变（ｐｒｏｌｉｆｅｒａｔｉｖｅｄｉａｂｅｔｉｃｒｅｔｉｎｏｐａｔｈｙ，ＰＤＲ） 组１５眼，高度近视合并糖尿病组１３眼，对玻璃体切割术中取出的玻璃体原液采用双抗体夹心酶联免疫吸附法（ＥＬＩＳＡ）进行ＶＥＧＦ、ＥＰＯ含量的测定。结果　对照组玻璃体中ＶＥＧＦ及ＥＰＯ浓度分别为（１５２．８±３５．２）ｐｇ?ｍＬ－１、（７４．３±１６．５）Ｕ?Ｌ－１； 高度近视组为（８１．３±１７．５）ｐｇ?ｍＬ－１、（６５．１±１３．７）Ｕ?Ｌ－１；ＰＤＲ组为（８２６．３±３６３．２）ｐｇ?ｍＬ－１、（６４９．８±２６７．９）Ｕ?Ｌ－１； 高度近视合并糖尿病组为（３０９．４±１３８．７）ｐｇ?ｍＬ－１、（１５６．２±５６．７）Ｕ?Ｌ－１，高度近视合并糖尿病组玻璃体中ＶＥＧＦ、ＥＰＯ浓度均低于ＰＤＲ组，差异均有统计学意义（均有Ｐ＜０．０５）。结论　高度近视对糖尿病患者玻璃体中ＶＥＧＦ和ＥＰＯ的表达具有抑制作用，ＶＥＧＦ和ＥＰＯ低表达可能在高度近视阻滞糖尿病视网膜病变的发生发展中发挥作用。
Abstract:
Objective By measuring the levels of vascular endothelial growth factor ( VEGF) and erythropoietin ( EPO) in the vitreous body of diabetes mellitus with high myopia , to investigate the influence mecharusm of high myopia on diabetic retinopathy ( DR) . Methods Enzyme-linked immunosorbent assay ( ELISA) was used to detect the levels of VEGF and EPO in the vitreous body of 62 retinal detachment patients from vitrectomy in our hospital. There were 18 eyes in control group, 16 eyes in high myopia group , 15 eyes in proliferative diabetic retinopathy ( PDR) group and 13 eyes in high myopia with diabetes mellitus group. The differences of the values of VEGF and EPO between each group were compared and analyzed. Results The levels of VEGF and EPO in control group were ( 152. 8 + 35. 2) pg . mL -l and ( 74. 3 + 16. 5) U . L -l , respectively, in high myopia group were (81. 3 + 17. 5) pg . mL-l and (65. I + 13. 7) U . L-l ,respectively, in PDR group were ( 826. 3 + 363. 2) pg . mL -l and ( 649. 8 +267. 9 ) U . L -l , respectively ,in high myopia with diabetes mellitus group were ( 309. 4 +138. 7 ) pg . mL -l and ( 156. 2 +56. 7) U . L ’1 , respectively. The levels of VEGF and EPO in high myopia with diabetes mellitus group were significantly lower than PDR group ( all P < 0. 05 ) . Conclusion High myopia suppresses the expression of VEGF and EPO in the vitreous body of diabetic patients , the low expression of these factors may take Dart in the mechanisms of high myopia on preventing DR.

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备注/Memo

备注/Memo:
河南省医学科技创新人才工程项目［豫卫科（２０１０）５２ 号］
更新日期/Last Update: 2014-05-04