参考文献/References:
［1］ SUN Y,XIONG L,WANG X,WANG L,CHEN B,HUANG J,et al.Autophagy inhibition attenuates TGF-β2-induced epithelial-mesenchymal transition in lens epithelial cells［J］.Life Sci,2021,265:118741.
［2］ IGARASHI N,HONJO M,YAMAGISHI R,KURANO M,YATOMI Y,IGARASHI K,et al.Crosstalk between transforming growth factor β-2 and autotaxin in trabecular meshwork and different subtypes of glaucoma［J］.J Biomed Sci,2021,28(1):47.
［3］ DONG H,WANG M,LI Q.Exosomal mir-4488 and mir-1273g-5p inhibit the epithelial-mesenchymal transition of transforming growth factor β2-mediated retinal pigment epithelial cells by targeting atp-binding cassette a4［J］.Bioengineered,2021,12(2):9693-9706.
［4］ DE MARTIN R,HAENDLER B,HOFER-WARBINEK R,GAUGITSCH H,WRANN M,SCHLUSENER H,et al.Complementary dna for human glioblastoma-derived t cell suppressor factor,a novel member of the transforming growth factor-beta gene family［J］.EMBO J,1987,6(12):3673-3677. XU X,ZHENG L,YUAN Q,ZHEN G,CRANE J L,ZHOU X,et al.Transforming growth factor-β in stem cells and tissue homeostasis［J］.Bone Res,2018,6:2.
［5］ CHEIFETZ S,WEATHERBEE J A,TSANG M L,ANDERSON J K,MOLE J E,LUCAS R,et al.The transforming growth factor-beta system,a complex pattern of cross-reactive ligands and receptors［J］.Cell,1987,48(3):409-415.
［6］ 陈亚楠,张学彦.转化生长因子βⅢ型受体在人类肿瘤发生发展中作用的研究进展［J］.现代肿瘤医学,2022,30(10):1907-1910.
CHEN Y N,ZHANG X Y.Research progress on the role of transforming growth factor βⅢ receptor in the development of human tumors［J］.J Mod.Oncol,2022,30(10):1907-1910.
［7］ TZAVLAKI K,MOUSTAKAS A.Tgf-β signaling［J］.Biomolecules,2020,10(3):487.
［8］ MIETZNER R,BREUNIG M.Causative glaucoma treatment:promising targets and delivery systems［J］.Drug Discov Today,2019,24(8):1606-1613.
［9］ GUO T,GUO L,FAN Y,FANG L,WEI J,TAN Y,et al.Aqueous humor levels of tgfβ2 and sfrp1 in different types of glaucoma［J］.BMC Ophthalmol,2019,19(1):170.
［10］ ZUKERMAN R,HARRIS A,VERCELLIN A V,SIESKY B,PASQUALE L R,CIULLA T A.Molecular genetics of glaucoma:subtype and ethnicity considerations［J］.Genes(Basel),2020,12(1):55.
［11］ DERAKHSHAN A,SADEGHI ALLAH ABADI J,TAVAKKOL-AFSHARI J,NIKPOOR A R,DANESHVAR R,SHOKOOHI RAD S,et al.Significant association and increased risk of primary open angle glaucoma with tgfβ2 rs991967 gene polymorphism in north eastern iranianpatients［J］.Rep Biochem Mol Biol,2019,7(2):210-216.
［12］ SCHNEIDER M,DILLINGER A E,OHLMANN A,IOZZO R V,FUCHSHOFER R.Decorin-an antagonist of tgf-β in astrocytes of the optic nerve［J］.Int J Mol Sci,2021,22(14):7660.
［13］ KENNEDY S M,SHERIDAN C,KEARNS V R,BILIR E K,FAN X,GRIERSON I.Thrombospondin-2 is up-regulated by tgfβ2 and increases fibronectin expression in human trabecular meshwork cells［J］.Exp Eye Res,2019,189:107820.
［14］ TSUKAMOTO T,KAJIWARA K,NADA S,OKADA M.Src mediates tgf-β-induced intraocular pressure elevation in glaucoma［J］.J Cell Physiol,2019,234(2):1730-1744.
［15］ RAO V R,STUBBS E B Jr.Tgf-β2 promotes oxidative stress in human trabecular meshwork cells by selectively enhancing nadphoxidase 4 expression［J］.Invest Ophthalmol Vis Sci,2021,62(4):4.
［16］ ZHANG J,WANG Y.Altered expression of extracellular vesicles mirnas from primary human trabecular meshwork cells induced by transforming growth factor-β2［J］.DNA Cell Biol,2021,40(7):988-997.
［17］ LOPEZ N N,RANGAN R,CLARK A F,TOVAR-VIDALES T.Mirna expression in glaucomatous and tgfβ2 treated lamina cribrosa cells［J］.Int J Mol Sci,2021,22(12):6178.
［18］ KELLY R A,PERKUMAS K M,CAMPBELL M,FARRAR G J,STAMER W D,HUMPHRIES P,et al.Fibrotic changes to schlemm’scanal endothelial cells in glaucoma［J］.Int J Mol Sci,2021,22(17):9446.
［19］ IGARASHI N,HONJO M,AIHARA M.Mtor inhibitors potentially reduce tgf-β2-induced fibrogenic changes in trabecular meshwork cells［J］.Sci Rep,2021,11(1):14111.
［20］ ZHU J D,XIE L L,LI Z Y,LU X H.The prognosis of trabeculectomy in primary angle-closure glaucoma patients［J］.Int J Ophthalmol,2019,12(1):66-72.
［21］ LIU H R,XIA Z Y,WANG N L.Sulforaphane modulates tgfβ2-induced conjunctival fibroblasts activation and fibrosis by inhibiting pi3k/akt signaling［J］.Int J Ophthalmol,2020,13(10):1505-1511.
［22］ PFEIFFER N,VOYKOV B,RENIERI G,BELL K,RICHTER P,WEIGEL M,et al.First-in-human phase I study of isth0036,an antisense oligonucleotide selectively targeting transforming growth factor beta 2(tgf-β2),in subjects with open-angle glaucoma undergoing glaucoma filtration surgery［J］.PLoS One,2017,12(11):e0188899
［23］ 朱晓燕，李磊，鲜光军,李海军,谭燕,谢琳.转化生长因子-β2诱导人Tenon囊成纤维细胞转化及其在瘢痕形成中的作用［J］.中华实验眼科杂志,2013,31(3):215-219.
ZHU X Y,LI L,XIAN G J,LI H J,TAN Y,XIE L.Effects of transforming growth factor-132 on human tenon fibroblasts transformation and scarring after glaucoma filtration surgery［J］.Chin J Exp Ophthalmol,2013,31(3):215-219.
［24］ 李晓萌,于颖欣,胡贵丽,刘小菁,毕宏生,郭大东.PI3K/Akt信号通路在眼科疾病发生发展过程中的调控作用研究进展［J］.眼科新进展,2021,41(6):588-592.
LI X M,YU Y X,HU G L,LIU X J,BI H S,GUO D D.Research advance in the regulatory role of pi3k/akt signaling pathway in the occurrence and development of eye diseases［J］.Rec Adv Ophthalmol,2021,41(6):588-592.
［25］ WANG X,WANG L,SUN Y,CHEN B,XIONG L,CHEN J,et al.Mir-22-3p inhibits fibrotic cataract through inactivation of hdac6 and increase of α-tubulin acetylation［J］.Cell Prolif,2020,53(11):e12911.
［26］ DONG N.Long noncoding rna neat1 regulates tgf-β2-induced epithelial-mesenchymal transition of lens epithelial cells through the mir-34a/snail1 and mir-204/zeb1 pathways［J］.Biomed Res Int,2020,2020:8352579.
［27］ CHEN X,XIAO W,CHEN W,LIU X,WU M,BO Q,et al.Microrna-26a and-26b inhibit lens fibrosis and cataract by negatively regulating jagged-1/notch signaling pathway［J］.Cell Death Differ,2017,24(8):1431-1442.
［28］ HUANG X,WANG Y,ZHANG P,ZOU H.A hgf derived peptide suppresses emtin human lens epithelial cells via the tgf β/smad and akt/mtor signaling pathways［J］.Mol Med Rep,2020,22(1):551-558.
［29］ LI H,SONG H,YUAN X,LI J,TANG H.Mir-30a reverses tgf-β2-induced migration and emt in posterior capsular opacification by targeting smad2［J］.Mol Biol Rep,2019,46(4):3899-3907.
［30］ SUGIYAMA Y,NAKAZAWA Y,SAKAGAMI T,KAWATA S,NAGAI N,YAMAMOTO N,et al.Capsaicin attenuates tgfβ2-induced epithelial-mesenchymal-transition in lens epithelial cells in vivo and in vitro［J］.Exp Eye Res,2021,213:108840.
［31］ LI Q,LIU S,YANG G,LI M,QIAO P,XUE Q.Naringenin inhibits autophagy and epithelial-mesenchymal transition of human lens epithelial cells by regulating the smad2/3 pathway［J］.Drug Dev Res,2022,83(2):389-396.
［32］ WILSON S E,TORRICELLI A A M,MARINO G K.Corneal epithelial basement membrane:structure,function and regeneration［J］.Exp Eye Res,2020,194:108002.
［33］ FUJIMOTO S,HAYASHI R,HARA S,SASAMOTO Y,HARRINGTON J,TSUJIKAWA M,et al.Klf4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous tgf-β2 suppression［J］.Regen Ther,2019,11:249-257.
［34］ ZHANG W,YU F,YAN C,SHAO C,GU P,FU Y,et al.Pten Inhibition accelerates corneal endothelial wound healing through increased endothelial cell division and migration［J］.InvestOphthalmol Vis Sci,2020,61(8):19.
［35］ JOKO T,SHIRAISHI A,KOBAYASHI T,OHASHI Y,HIGASHIYAMA S.Mechanism of proliferation of cultured human corneal endothelial cells［J］.Cornea,2017,36:S41-S45.
［36］ QIN D,JIN X,JIANG Y.Gremlin mediates the tgf-β-induced induction of profibrogenic genes in human retinal pigment epithelial cells［J］.Exp Ther Med,2020,19(3):2353-2359.
［37］ YANG I H,LEE J J,WU P C,KUO H K,KUO Y H,HUANG H M.Oxidative stress enhanced the transforming growth factor-β2-induced epithelial-mesenchymal transition through chemokine ligand 1 on arpe-19 cell［J］.Sci Rep,2020,10(1):4000.
［38］ ZHANG W,LI J.Yes-associated protein is essential for proliferative vitreoretinopathy development via the epithelial-mesenchymal transition in retinal pigment epithelial fibrosis［J］.Cell Mol Med,2021,25(21):10213-10223.
［39］ MIAO Q,XU Y,YIN H,ZHANG H,YE J.Krt8 phosphorylation regulates the epithelial-mesenchymal transition in retinal pigment epithelial cells through autophagy modulation［J］.Cell Mol Med,2020,24(5):3217-3228.
［40］ WANG Z Y,ZHANG Y,CHEN J,WU L D,CHEN M L,CHEN C M,et al.Artesunate inhibits the development of pvr by suppressing the tgf-β/smad signaling pathway［J］.Exp Eye Res,2021,213:108859.
［41］ WANG Z Y,ZHANG Y,WU L D,CHEN J,CHEN M L,CHEN C M,et al.Artesunate inhibits proliferation and migration of rpe cells and tgf-β2 mediated epithelial mesenchymal transition by suppressing pi3k/akt pathway［J］.Int J Ophthalmol,2022,15(2):197-204.
［42］ WANG W Y,CHEN C,CHANG J,CHIEN L,SHIH Y F,LIN L L K,et al.Pharmacotherapeutic candidates for myopia:a review［J］.Biomed Pharmacother,2021,133:111092.
［43］ 徐福如,蒋文君,吴建峰,毕宏生.近视性巩膜重塑相关因子研究进展［J］.眼科新进展,2019,39(9):877-881.
XU F R,JIANG W J,WU J F,BI H S.Recent advance on cytokines associated with scleral remodeling in myopia［J］.Rec Adv Ophthalmol,2019,39(9):877-881.
［44］ JIA Y,YUE Y,HU D N,CHEN J L,ZHOU J B.Human aqueous humor levels of transforming growth factor-β2:association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases［J］.Biomed Rep,2017,7(6):573-578.
［45］ CHEN B Y,WANG C Y,CHEN W Y,MA J X.Altered tgf-β2 and bfgf expression in scleral desmocytes from an experimentally-induced myopia guinea pig model［J］.Graefes Arch Clin Exp Ophthalmol,2013,251(4):1133-1144.
［46］ ZHAO F,ZHOU H,CHEN W,ZHAO C,ZHENG Y,TAO Y,et al.Declines in pde4b activity promote myopia progression through downregulation of scleral collagen expression［J］.Exp Eye Res,2021,212:108758.
［47］ 吕晓彤,宋彦铮,张丰菊.近视眼相关Lumican基因突变对人巩膜成纤维细胞中bFGF和TGF-β2的影响［J］.中华眼科杂志,2021,57(4):277-283.
L X T,SONG Y Z,ZHANG F J.Regulation of BFGF and TGF-β2 in human scleral fibroblasts by the lumican gene mutation associated with myopia［J］.Chin J Ophthalmol,2021,57(4):277-283.