[1]赵宇辉,毕宏生,田庆梅,等.单细胞转录组测序技术在眼科相关研究中的应用研究进展[J].眼科新进展,2023,43(3):244-248.[doi:10.13389/j.cnki.rao.2023.0050]
 ZHAO Yuhui,BI Hongsheng,TIAN Qingmei,et al.Application of single-cell ribonucleic acid-sequencing technology in ophthalmology-related research[J].Recent Advances in Ophthalmology,2023,43(3):244-248.[doi:10.13389/j.cnki.rao.2023.0050]
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单细胞转录组测序技术在眼科相关研究中的应用研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
43卷
期数:
2023年3期
页码:
244-248
栏目:
文献综述
出版日期:
2023-03-05

文章信息/Info

Title:
Application of single-cell ribonucleic acid-sequencing technology in ophthalmology-related research
作者:
赵宇辉毕宏生田庆梅卢秀珍
250014 山东省济南市,山东中医药大学(赵宇辉,毕宏生,田庆梅,卢秀珍);250002 山东省济南市,山东中医药大学附属眼科医院,山东省中西医结合眼病防治重点实验室,山东省眼病防治研究院(毕宏生,田庆梅,卢秀珍)
Author(s):
ZHAO Yuhui1BI Hongsheng12TIAN Qingmei12LU Xiuzhen12
1.Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong Province,China
2.Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine,Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases,Shandong Academy of Eye disease Prevention and Therapy,Jinan 250002,Shandong Province,China
关键词:
单细胞转录组测序眼科异质性
Keywords:
single-cell ribonucleic acid-sequencing ophthalmology heterogeneity
分类号:
R77
DOI:
10.13389/j.cnki.rao.2023.0050
文献标志码:
A
摘要:
单细胞转录组测序(scRNA-seq)技术可以从单细胞水平获得全转录组的表达谱,并发现罕见细胞类型及其亚型,鉴定细胞特异性标记物,充分注重了细胞间或细胞亚型间的差异,被广泛地应用于肿瘤治疗、生殖生育、免疫学、神经科学、微生物学等领域。近年来,眼科领域研究也逐渐引入了scRNA-seq技术,本文将对 scRNA-seq 技术在眼科基础以及疾病研究的应用进展进行综述。
Abstract:
Single-cell ribonucleic acid-sequencing (scRNA-seq) technology can obtain the expression profiling of the whole transcriptome from the single-cell level, discover rare cell types and subtypes, identify cell-specific markers, and find the differences between cells or cell subtypes. It is widely used in tumor treatment, genesiology, immunology, neurology, microbiology and other fields. In recent years, scRNA-seq has been gradually applied to ophthalmic research. This paper will review the application of scRNA-seq technology in fundamental and disease research of ophthalmology.

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备注/Memo

备注/Memo:
山东省自然科学基金项目资助(编号:ZR2020QH314),山东省医药科技发展计划项目(编号:2019WS570,2019WS572)
更新日期/Last Update: 2023-03-05