参考文献/References:
[1] TANG Z,ZHANG Y,WANG Y,ZHANG D,SHEN B,LUO M,et al.Progress of stem/progenitor cell-based therapy for retinal degeneration[J].J Transl Med,2017,15(1):99.
[2] REH T A.Photoreceptor transplantation in late stage retinal degeneration[J].Invest Ophthalmol Vis Sci,2016,57(5):ORSFg1-7.
[3] LETAVIC M A,LORD B,BISCHOFF F,HAWRYLUK N A,PIETERS S,RECH J C,et al.Synthesis and pharmacological characterization of two novel,brain penetrating P2X7 antagonists[J].ACS Med Chem Lett,2013,4(4):419-422.
[4] SUGIYAMA T,LEE S Y,HORIE T,OKU H,TAKAI S,TANIOKA H,et al.P2X7 receptor activation may be involved in neuronal loss in the retinal ganglion cell layer after acute elevation of intraocular pressure in rats[J].Mol Vis,2013,19:2080-2091.
[5] CRABB M,PERREN A V D,BOLLAERTS I,KOUNELIS S,BAEKELANDT V,BORMANS G,et al.Increased P2X7 receptor binding is associated with neuroinflammation in acute but not chronic rodent models for parkinson’s disease[J].Front Neurosci,2019,13:799.
[6] TEWARI M,SETH P.Emerging role of P2X7 receptors in CNS health and disease[J].Ageing Res Rev,2015,24(Pt B):328-342.
[7] MITCHELL C H,LU W,HU H,ZHANG X,REIGADA D,ZHANG M.The P2X(7) receptor in retinal ganglion cells:a neuronal model of pressure-induced damage and protection by a shifting purinergic balance[J].Purinergic Signalling,2009,5(2):241-249.
[8] VESSEY K A,FLETCHER E L.Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse[J].PLoS One,2012,7(1):e29990.
[9] VESSEY K A,GU B J,JOBLING A I,PHIPPS J A,GREFERATH U,TRAN M X,et al.Loss of function of P2X7 receptor scavenger activity in aging mice:a novel model for investigating the early pathogenesis of age-related macular degeneration[J].Am J Pathol,2017,187(8):1670-1685.
[10] ILLES P,MLLER C E,JACOBSON K A,GRUTTER T,NICKE A,FOUNTAIN S J,et al.Update of P2X receptor properties and their pharmacology:IUPHAR review 30[J].Br J Pharmacol,2020,178(3):489-514.
[11] JACOBSON K A,DELICADO E G,GACHET C,KENNEDY C,KGELGEN I,LI B,et al.Update of P2Y receptor pharmacology:IUPHAR review 27[J].Br J Pharmacol,2020,177(11):2413-2433.
[12] 徐宏,梁尚栋.P2X7受体在炎症性疾病中的作用及其机制[J].生理学报,2013,65(2):244-252.
XU H,LIANG S D.Effect of P2X7 receptor on inflammatory diseases and its mechanism[J].Acta Phy Sin,2013,65(2):244-252.
[13] MONO-RIBEIRO L C,FAFFE D S,SANTANA P T,VIEIRA F S,DAGRAA C L,MARQUES-DA-SILVA C,et al.P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica[J].PLoS One,2017,9(10):e110185.
[14] CODDOU C,YAN Z,OBSIL T,HUIDOBRO-TORO J P,STOJILKOVIC S S.Activation and regulation of purinergic P2X receptor channels[J].Pharmacol Rev,2011,63(3):641-683.
[15] LIANG X,SAMWAYS D S K,WOLF K,BOWLES E A,RICHARDS J P,BRUNO J,et al.Quantifying Ca2+ current and permeability in ATP-gated P2X7 receptors[J].J Biol Chem,2015,290(12):7930-7942.
[16] SUGIYAMA T.Role of P2X7 receptors in neuronal death in the retina[J].Neural Regen Res,2014,9(6):579-581.
[17] SMITH S M C,MITCHELL G S,FRIEDLE S A,SIBIGTROTH C M,VINIT S,WATTERS J J.Hypoxia attenuates purinergic P2X receptor-induced inflammatory gene expression in brainstem microglia[J].Hypoxia,2013,2013(1):1-11.
[18] VENTURA A L M,SANTOS-RODRIGUES A D,MITCHELL C H,FAILLACE M P.Purinergic signaling in the retina:from development to disease[J].Brain Res Bull,2019,151:92-108.
[19] NOTOMI S,HISATOMI T,KANEMARU T,TAKEDA A,IKEDA Y,ENAIDA H,et al.Critical involvement of extracellular ATP acting on P2RX7 purinergic receptors in photoreceptor cell death[J].Am J Pathol,2011,179(6):2798-2809.
[20] REICHENBACH A,BRINGMANN A.Role of purines in müller glia[J].J Ocul Pharmacol Ther,2016,32(8):518.
[21] LI L,LIU J,XU A,HEIDUSCHKA P,ETER N,CHEN C.Expression of purinergic receptors on microglia in the animal model of choroidal neovascularisation[J].Sci Rep,2021,11(1):12389.
[22] FLETCHER E L,WANG A Y,JOBLING A I,RUTAR M V,GREFERATH U,GU B,et al.Targeting P2X7 receptors as a means for treating retinal disease[J].Drug Discov Today,2019,24(8):1598-1605.
[23] VIRGILIO F D,GIULIANI A L,VULTAGGIO-POMA V,FALZONI S,SARTI A C.Non-nucleotide agonists triggering P2X7 receptor activation and pore formation[J].Front Pharmacol,2018,9:39.
[24] JIANG L.Inhibition of P2X7 receptors by divalent cations:old action and new insight[J].Eur Biophys J,2009,38(3):339-346.
[25] GU B J,BAIRD P N,VESSEY K A,SKARRATT K K,FLETCHER E L,FULLER S J,et al.A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration[J].FASEB J,2013,27(4):1479-1487.
[26] PUTHUSSERY T,FLETCHER E.Extracellular ATP induces retinal photoreceptor apoptosis through activation of purinoceptors in rodents[J].J Comp Neurol,2009,513(4):430-440.
[27] APLIN F P,LUU C D,VESSEY K A,GUYMER R H,SHEPHERD R K,FLETCHER E L.ATP-induced photoreceptor death in a feline model of retinal degeneration[J].Invest Ophthalmol Vis Sci,2014,55(12):8319-8329.
[28] FRANKE H,KLIMKE K,BRINCKMANN U,GROSCHE J,FRANCKE M,SPERLAGH B,et al.P2X(7) receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds mice[J].Neurochem Int,2005,47(4):235-242.
[29] NOTOMI S,HISATOMI T,MURAKAMI Y,TERASAKI H,SONODA S,ASATO R,et al.Dynamic increase in extracellular ATP accelerates photoreceptor cell apoptosis via ligation of P2RX7 in subretinal hemorrhage[J].PLoS One,2013,8(1):e53338.
[30] TAYLOR A W,HSU S,NG T F.The role of retinal pigment epithelial cells in regulation of macrophages/microglial cells in retinal immunobiology[J].Front Immunol,2021,12:724601.
[31] YANG D,ELNER S G,CLARK A J,HUGHES B A,PETTY H R,ELNER V M.Activation of P2X receptors induces apoptosis in human retinal pigment epithelium[J].Invest Ophthalmol Vis Sci,2011,52(3):1522-1530.
[32] FOWLER B J,GELFAND B D,KIM Y,KERUR N,TARALLO V,HIRANO Y,et al.Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity[J].Science,2014,346(6212):1000-1003.
[33] SHAO X,GUHA S,LU W,CAMPAGNO K E,BECKEL J M,MILLS J A,et al.Polarized cytokine release triggered by P2X7 receptor from retinal pigmented epithelial cells dependent on calcium influx[J].Cells,2020,9(12):2537.
[34] HU H,LU W,ZHANG M,ZHANG X,ARGALL A J,PATEL S,et al.Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo[J].Exp Eye Res,2010,91(3):425-432.
[35] HAO X H,PEI Y,SUN X N.Effect of P2X7 purinoceptor on hypoxia-induced apoptosis of retinal ganglion cells[J].Int Eye Sci,2016,16(4):622-624.
[36] SUGIYAMA T,OKU H,SHIBATA M,FUKUHARA M,YOSHIDA H,IKEDA T.Involvement of P2X7 receptors in the hypoxia-induced death of rat retinal neurons[J].Invest Ophthalmol Vis Sci,2010,51(6):3236-3243.
[37] NIYADURUPOLA N,SIDAWAY P,MA N,RHODES J D,BROADWAY D C,SANDERSON J.P2X7 receptor activation mediates retinal ganglion cell death in a human retina model of ischemic neurodegeneration[J].Invest Ophthalmol Vis Sci,2013,54(3):2163-2170.
[38] ABCOUWER S F.Müller cell-microglia cross talk drives neuroinflammation in diabetic retinopathy[J].Diabetes,2017,66(2):261-263.
[39] LARA M J P D,GUZMN-ARNGUEZ A,VILLA P D L,DAZ-HERNNDEZ J I,MIRAS-PORTUGAL M T,PINTOR J.Increased levels of extracellular ATP in glaucomatous retinas:possible role of the vesicular nucleotide transporter during the development of the pathology[J].Mol Vis,2015,21:1060-1070.
[40] LARA M J P D,AVILS-TRIGUEROS M,GUZMN-ARNGUEZ A,VALIENTE-SORIANO F J,VILLA P D L,VIDAL-SANZ M,et al.Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma[J].Brain Res Bull,2019,150:61-74.
[41] ROMANO G L,AMATO R,LAZZARA F,PORCIATTI V,CHOU T-H,DRAGO F,et al.P2X7 receptor antagonism preserves retinal ganglion cells in glaucomatous mice[J].Biochem Pharmacol,2020,180:114199.
[42] ZHANG Y,XU Y,SUN Q,XUE S,GUAN H,JI M.Activation of P2X7R- NLRP3 pathway in retinal microglia contribute to retinal ganglion cells death in chronic ocular hypertension(COH)[J].Exp Eye Res,2019,188:107771.
[43] ALBALAWI F,LU W,BECKEL J M,LIM J C,MCCAUGHEY S A,MITCHELL C H.The P2X7 receptor primes IL-1β and the NLRP3 inflammasome in astrocytes exposed to mechanical strain[J].Front Cell Neurosci,2017,11:227.
[44] LU W,ALBALAWI F,BECKEL J M,LIM J C,LATIES A M,MITCHELL C H.The P2X7 receptor links mechanical strain to cytokine IL-6 up-regulation and release in neurons and astrocytes[J].J Neurochem,2017,141(3):436-448.
[45] BECKEL J M,ARGALL A J,LIM J C,XIA J,LU W,COFFEY E E,et al.Mechanosensitive release of adenosine 5’-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes:a mechanism for purinergic involvement in chronic strain[J].Glia,2014,62(9):1486-1501.
[46] LOIOLA E C,VENTURA A L M.Release of ATP from avian müller glia cells in culture[J].Neurochem Int,2011,58(3):414-422.
[47] XUE B,XIE Y,XUE Y,HU N,ZHANG G,GUAN H,et al.Involvement of P2X7 receptors in retinal ganglion cell apoptosis induced by activated müller cells[J].Exp Eye Res,2016,153:42-50.
[48] 薛博,季敏,管怀进.ATP与P2X_7受体在Müller细胞激活导致视网膜神经节细胞株RGC-5凋亡中的作用研究[J].南京医科大学学报(自然科学版),2016,36(2):182-188.
XUE B,JI M,GUAN H J.Involvement of P2X7 receptor and ATP in Müller cell gliosis induced RGC-5 cells apoptosis[J].Acta Univ Med Nanjing(Nat Sci),2016,36(2):182-188.
[49] XUE Y,XIE Y,XUE B,HU N,ZHANG G,GUAN H,et al.Activated müller cells involved in ATP-induced upregulation of P2X7 receptor expression and retinal ganglion cell death[J].Biomed Res Int,2016,2016:9020715.
[50] ARULKUMARAN N,UNWIN R J,TAM F W.A potential therapeutic role for P2X7 receptor(P2X7R) antagonists in the treatment of inflammatory diseases[J].Expert Opin Invest Drugs,2011,20(7):897-915.
[51] CHEN J Y,TENG Y,YANG M M.Role of inflammatory regulators in neovascularization of diabetic retinopathy[J].Int Eye Sci,2021,21(8):1390-1393.
[52] GAO J,LIU R T,CAO S,CUI J Z,WANG A,TO E,et al.NLRP3 inflammasome:activation and regulation in age-related macular degeneration[J].Mediators Inflamm,2015,2015:690243.
[53] RBSAM A,PARIKH S,FORT P E.Role of inflammation in diabetic retinopathy[J].Int J Mol Sci,2018,19(4):942.
[54] PLATANIA C B M,LAZZARA F,FIDILIO A,FRESTA C G,CONTI F,GIURDANELLA G,et al.Blood-retinal barrier protection against high glucose damage:the role of P2X7 receptor[J].Biochem Pharmacol,2019,168:249-258.
[55] PLATANIA C B M,GIURDANELLA G,PAOLA L D,LEGGIO G M,DRAGO F,SALOMONE S,et al.P2X7 receptor antagonism:implications in diabetic retinopathy[J].Biochem Pharmacol,2017,138:130-139.
[56] ZUO W,ZHU Y Y,YU H T,LI H L,ZHOU J W,WANG H.Effect of purine receptor P2X7 in pericyte of retinal microvascular apoptosis[J].Int Eye Sci,2014,14(4):603-605.
[57] HILL L M,GAVALA M L,LENERTZ L Y,BERTICS P J.Extracellular ATP may contribute to tissue repair by rapidly stimulating purinergic receptor X7-dependent vascular endothelial growth factor release from primary human monocytes[J].J Immunol,2010,185(5):3028-3034.
[58] FRESTA C G,CARUSO G,FIDILIO A,PLATANIA C B M,MUSSO N,CARACI F,et al.Dihydrotanshinone,a natural diterpenoid,preserves blood-retinal barrier integrity via P2X7 receptor[J].Int J Mol Sci,2020,21(23):9305.
[59] CHAURASIA S S,LIM R R,PARIKH B H,WEY Y S,TUN B B,WONG T Y,et al.The NLRP3 inflammasome may contribute to pathologic neovascularization in the advanced stages of diabetic retinopathy[J].Sci Rep,2018,8(1):2847.
[60] CLAPP C,DIAZ-LEZAMA N,ADAN-CASTRO E,RAMIREZ-HERNANDEZ G,MORENO-CARRANZA B,SARTI A C,et al.Pharmacological blockade of the P2X7 receptor reverses retinal damage in a rat model of type 1 diabetes[J].Acta Diabetol,2019,56(9):1031-1036.
[61] BARTLETT R,STOKES L,SLUYTER R.The P2X7 receptor channel:recent developments and the use of P2X7 antagonists in models of disease[J].Pharmacol Rev,2014,66(3):638-675.
[62] FENG L,CHEN Y,DING R,FU Z,YANG S,DENG X,et al.P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage:involvement of peroxynitrite[J].J Neuroinflammat,2015,12(1):190.
[63] 许阿敏,李璐,陈长征,易佐慧子,王晓玲,刘珏君.小胶质细胞P2X7-NLRP3/caspase-1通路在脉络膜新生血管中的作用机制[J].武汉大学学报(医学版),2020,41(4):568-573.
XU A M,LI L,CHEN C Z,YI-ZUO H Z,WANG X L,LIU J J.Mechanism of microglia via P2X7-NLRP3/caspase-1 pathway in choroidal neovascularization[J].Med J Wuhan Univ,2020,41(4):568-573.
[64] FRANCESCHINI A,CAPECE M,CHIOZZI P,FALZONI S,SANZ J M,SARTI A C,et al.The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein[J].FASEB J,2015,29(6):2450-2461.
[65] CARTA S,PENCO F,LAVIERI R,MARTINI A,DINARELLO C A,GATTORNO M,et al.Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases,resulting in cytokine imbalance[J].Proc Natl Acad Sci U S A,2015,112(9):2835-2840.
[66] BARON L,GOMBAULT A,FANNY M,VILLERET B,SAVIGNY F,GUILLOU N,et al.The NLRP3 inflammasome is activated by nanoparticles through ATP,ADP and adenosine[J].Cell Death Dis,2015,6(2):e1629.
[67] 石蕊,王博,杨乐.非诺贝特对糖尿病视网膜病变小鼠视网膜神经细胞的保护作用及机制[J].眼科新进展,2019,39(6):528-531.
SHI R,WANG B,YANG L.Protective effect and mechanism of Fenofibrate on retinal neuro cells in mice with diabetic retinopathy[J].Rec Adv Ophthalmol,2019,39(6):528-531.
[68] YANG M,QIU R,WANG W,LIU J,JIN X,LI Y,et al.P2X7 receptor antagonist attenuates retinal inflammation and neovascularization induced by oxidized low-density lipoprotein[J].Oxid Med Cell Longev,2021,2021:5520644.
[69] 张艳莉,赵岐,黄强.P2X7受体阻断对碘酸钠诱导的年龄相关性黄斑变性小鼠NLRP3/Caspase-1通路的影响[J].热带医学杂志,2020,20(7):865-869.
ZHANG Y L,ZHAO Q,HUANG Q.Effect of P2X7 receptor blockade on NLRP3/Caspase-1 pathway in age-related macular degeneration mice induced by sodium iodate[J].J Trop Med,2020,20(7):865-869.
[70] CLARK A K,MALCANGIO M.Fractalkine/CX3CR1 signaling during neuropathic pain[J].Front Cell Neurosci,2014,8:121.
[71] CLARK A K,YIP P K,GRIST J,GENTRY C,STANILAND A A,MARCHAND F,et al.Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain[J].Proc Natl Acad Sci U S A,2007,104(25):10655-10660.
[72] GAO Y H,LI C W,WANG J Y,TAN L H,DUANMU C L,JING X H,et al.Effect of electroacupuncture on the cervicospinal P2X7 receptor/fractalkine/CX3CR1 signaling pathway in a rat neck-incision pain model[J].Purinergic Signal,2017,13(2):215-225.
[73] SAKAMOTO K,ENDO K,SUZUKI T,FUJIMURA K,KURAUCHI Y,MORI A,et al.P2X7 receptor antagonists protect against N-methyl-D-aspartic acid-induced neuronal injury in the rat retina[J].Eur J Pharmacol,2015,756:52-58.
[74] NAIR C E M,SCHLAMP C L,MONTGOMERY A D,SHESTOPALOV V I,NICKELLS R W.Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways[J].J Neuroinflammation,2016,13(1):93.
[75] DONG L,HU Y,ZHOU L,CHENG X.P2X7 receptor antagonist protects retinal ganglion cells by inhibiting microglial activation in a rat chronic ocular hypertension model[J].Mol Med Report,2018,17(2):2289-2296.
[76] VIRGILIO F D,BEN D D,SARTI A C,GIULIANI A L,FALZONI S.The P2X7 receptor in infection and inflammation[J].Immunity,2017,47(1):15-31.