[1]毕雪,李轩.Sirt1治疗后发性白内障的研究进展[J].眼科新进展,2020,40(7):686-690.[doi:10.13389/j.cnki.rao.2020.0157]
　BI Xue,LI Xuan.The research advances of Sirt1 in the treatment of posterior capsular opacification[J].Recent Advances in Ophthalmology,2020,40(7):686-690.[doi:10.13389/j.cnki.rao.2020.0157]
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Sirt1治疗后发性白内障的研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
40卷
期数:
2020年7期
页码:
686-690
栏目:
文献综述
出版日期:
2020-07-05

文章信息/Info

Title:
The research advances of Sirt1 in the treatment of posterior capsular opacification
作者:
毕雪; 李轩
300020　天津市，天津医科大学眼科临床学院　天津市眼科医院　天津市眼科学与视觉科学重点实验室　天津市眼科研究所
Author(s):
BI Xue;  LI Xuan
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Institute of Ophthalmology, Tianjin 300020, China
关键词:
Sirt1; microRNA; 后发性白内障
Keywords:
Sirt1; microRNA; posterior capsular opacification
分类号:
R776.1
DOI:
10.13389/j.cnki.rao.2020.0157
文献标志码:
A
摘要:
Sirt1是sirtuin家族中研究较为广泛和深入的成员。Sirt1如交通枢纽一般，连接上游microRNA及下游各种转录因子，在抗衰老、细胞凋亡、氧化应激和DNA损伤方面发挥显著作用。后发性白内障（posterior capsular opacification,PCO）是导致白内障患者术后视力下降最常见的并发症。目前国内外研究尚未有Sirt1对PCO的发生发展的体内、外相关研究。本文综述了Sirt1生物学作用的主要路径以及Sirt1在后发性白内障治疗中的前景展望。
Abstract:
Sirt1 is an extensive and in-depth member of the sirtuin family. Like a transportation hub, it connects upstream microRNA and various downstream transcription factors, and plays an important role in anti-aging, cell apoptosis, oxidative stress and DNA damage. Posterior capsular opacification (PCO) is the most common complication of postoperative visual acuity loss in cataract patients. At present, there are no in vivo and in vitro studies on the occurrence and development of PCO by Sirt1. This article provides a review on the main pathways of biological action of Sirt1 and the prospect of Sirt1 in the treatment of PCO.

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备注/Memo

备注/Memo:
国家自然科学基金资助（编号：81670837）；天津市应用基础与前沿技术研究计划项目（编号：15JCZDJC35300）；天津市卫生行业重点攻关项目（编号：14KGI33）
更新日期/Last Update: 2020-07-05