[1]叶蕾,刘康成,骆仲舟,等.功能裂隙灯生物显微镜对正常成人结膜微血管血流动力学指标的检测和临床应用价值[J].眼科新进展,2017,37(10):935-938.[doi:10.13389/j.cnki.rao.2017.0237]
 YE Lei,LIU Kang-Cheng,LUO Zhong-Zhou,et al.Functional slit lamp biomicroscopy detects hemodynamics parameters of conjunctival microvessel in normal adults and its clinical values[J].Recent Advances in Ophthalmology,2017,37(10):935-938.[doi:10.13389/j.cnki.rao.2017.0237]
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功能裂隙灯生物显微镜对正常成人结膜微血管血流动力学指标的检测和临床应用价值/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
37卷
期数:
2017年10期
页码:
935-938
栏目:
应用研究
出版日期:
2017-10-05

文章信息/Info

Title:
Functional slit lamp biomicroscopy detects hemodynamics parameters of conjunctival microvessel in normal adults and its clinical values
作者:
叶蕾刘康成骆仲舟容蓉钟菁唐丽媛鲍静袁进邵毅
330006 江西省南昌市,南昌大学第一附属医院眼科(叶蕾,刘康成,容蓉,唐丽媛,鲍静,邵毅);510060 广东省广州市,中山大学中山眼科中心(骆仲舟,钟菁,袁进)
Author(s):
YE LeiLIU Kang-ChengLUO Zhong-ZhouRONG RongZHONG JingTANG Li-YuanBAO JingYUAN JinSHAO Yi
Department of Ophthalmology,the First Affiliated Hospital of Nanchang University (YE Lei,LIU Kang-Cheng,RONG Rong,TANG Li-Yuan,BAO Jing,SHAO Yi),Nanchang 330006,Jiangxi Province,China;Department of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University(LUO Zhong-Zhou,ZHONG Jing,YUAN Jin),Guangzhou 510060,Guangdong Province,China
关键词:
结膜微血管功能裂隙灯生物显微镜
Keywords:
conjunctivamicrovesselfunctional slit lamp biomicroscopy
分类号:
R777.3
DOI:
10.13389/j.cnki.rao.2017.0237
文献标志码:
A
摘要:
目的 探讨功能裂隙灯生物显微镜(functional slit lamp biomicroscopy,FSLB)对正常成人结膜微血管血流动力学指标的检测和临床应用价值。方法 随机抽取南昌大学医学院和中山眼科中心硕士研究生16人,其中男8人,女8人;年龄21~25岁。应用FSLB并使用软件程序(BenoitTM,TruSoft Inc,St.Petersburg,FL,USA)对受试者结膜微血管密度、微血管长度、微血管直径、微动脉血流速度、微静脉血流速度等指标进行检测,并分析受试者各指标特征。结果 受试者右眼微血管密度、长度、直径、微动脉血流速度、微静脉血流速度上方和下方、鼻侧和颞侧差异均无统计学意义(均为P>0.05);受试者右眼微血管密度、长度、直径上方、下方均较鼻侧、颞侧减小,差异均有统计学意义(均为P<0.05);受试者微动脉血流速度、微静脉血流速度右眼上方、下方均较鼻侧、颞侧明显增加,差异均有统计学意义(均为P<0.05)。左眼以及总眼数的情况和右眼相一致。结论 利用FSLB可以较为清晰地获得正常成人结膜微血管血流动力学指标,有很好的临床价值。
Abstract:
Objective To investigate the detection of hemodynamics parameters of conjunctival microvessels by functional slit lamp biomicroscopy (FSLB) in normal adult and its clinical application values.Methods Randomly selected 16 postgraduate students aged 21 to 25 years from the Nanchang University and Zhongshan Ophthalmic Center,including 8 males and 8 females.The density,length and diameter of conjunctival microvessel and the flow velocity of arteriolar and venular blood were measured by FSLB and software program (BenoitTM,TruSoft Inc,St.Petersburg,FL,USA),as well as the indicators’ characteristics of the subjects’ were analyzed.Results As for subjects’ right eyes,the microvascular density,length,diameter,and the arteriolar and venular blood flow velocity were no significant difference between the upper,and lower sides,as well as between nasal and temporal sides (all P>0.05);meanwhile the microvascular density,length and diameter of the upper and lower sides were both lower than those of the nasal and temporal sides,and the differences were statistically significant (all P<0.05),while the arteriolar and venular blood flow velocity of the upper and lower sides were both significantly higher than those of the nasal and temporal sides,and the differences were statistically significant (all P<0.05).In addition,the changes in hemodynamics parameters of conjunctival microvessels of the left eyes and total eyes in subjects were consistent with the right eyes.Conclusion FSLB can clearly obtain hemodynamics parameters of conjunctival microvessels in healthy grown-ups,and has a promising clinical value.

参考文献/References:

[1] JUNG F,KORBER N,KIESEWETTER H,PRUNTE C,WOLF S,REIM M.Measuring the microcirculation in the human conjunctiva bulbi under normal and hyperperfusion conditions[J].Graefe Arch Clin Exp,1983,220 (6):294-297.
[2] OHTANI N.Laser Doppler flowmetry of the bulbar conjunctiva as a monitor of the cerebral blood flow[J].Nihon Kyobu Geka Gakkai Zasshi,1996,44 (9):1721-1728.
[3] SCHASER KD,SETTMACHER U,PUHL G,ZHANG L,MITTLMEIER T,STOVER JF,et al.Noninvasive analysis of conjunctival microcirculation during carotid artery surgery reveals microvascular evidence of collateral compensation and stenosis-dependent adaptation[J].J Vasc Surg,2003,37 (4):789-797.
[4] DUENCH S,SIMPSON T,JONES LW,FLANAGAN JG,FONN D.Assessment of variation in bulbar conjunctival redness,temperature,and blood flow[J].Optom Vis Sci,2007,84 (6):511-516.
[5] KOUTSIARIS AG,TACHMITZI SV,PAPAVASILEIOU P,BATIS N,KOTOULA MG,GIANNOUKAS AD,et al.Blood velocity pulse quantification in the human conjunctival pre-capillary arterioles[J].Microvasc Res,2010,80 (2):202-208.
[6] SHAHIDI M,WANEK J,GAYNES B,WU T.Quantitative assessment of conjunctival microvascular circulation of the human eye[J].Microvasc Res,2010,79 (2):109-113.
[7] WANEK J,GAYNES B,LIM JI,MOLOKIE R,SHAHIDI M.Human bulbar conjunctival hemodynamics in hemoglobin SS and SC disease[J].Am J Hematol,2013,88 (8):661-664.
[8] CHEUNG AT,HARMATZ P,WUN T,CHEN PC,LARKIN EC,ADAMS RJ,et al.Correlation of abnormal intracranial vessel velocity,measured by transcranial Doppler ultrasonography,with abnormal conjunctival vessel velocity,measured by computer-assisted intravital microscopy,in sickle cell disease[J].Blood,2001,97(11):3401-3404.
[9] CHEUNG AT,TOMIC MM,CHEN PC,MIGUELINO E,LI CS,DEVARAJ S.Correlation of microvascular abnormalities and endothelial dysfunction in Type-1 Diabetes Mellitus (T1 DM):a real-time intravital microscopy study[J].Clin Hemorheol Microcirc,2009,42 (4):285-295.
[10] TO WJ,TELANDER DG,LLOYD ME,CHEN PC,CHEUNG AT.Correlation of conjunctival microangiopathy with retinopathy in type-2 diabetes mellitus (T2 DM) patients[J].Clin Hemorheol Microcirc,2011,47 (2):131-141.
[11] CHEUNG AT,HU BS,WONG SA,CHOW J,CHAN MS,TO WJ,et al.Microvascular abnormalities in the bulbar conjunctiva of contact lens users[J].Clin Hemorheol Microcirc,2012,51 (1):77-86.
[12] JIANG H,ZHONG J,DEBUC DC,TAO A,XU Z,LAM BL,et al.Functional slit lamp biomicroscopy for imaging bulbar conjunctival microvasculature in contact lens wearers[J].Microvasc Res,2014,92 (3):62-71.
[13] DENEUX T,TAKERKART S,GRINVALD A,MASSON GS,VANZETTA I.A processing work-flow for measuring erythrocytes velocity in extended vascular networks from wide field high-resolution optical imaging data[J].Neuroimage,2012,59 (3):2569-2588.
[14] MCNALLY JJ,CHALMERS RL,MCKENNEY CD,ROBIRDS S.Risk factors for corneal infiltrative events with 30-night continuous wear of silicone hydrogel lenses[J].Eye Contact Lens,2003,29(1 Suppl):S153-156.
[15] SZCZOTKAFLYNN L,JIANG Y,RAGHUPATHY S,BIELEFELD RA,GARVEY MT,JACOBS MR,et al.Corneal inflammatory events with daily silicone hydrogel lens wear[J].Optom Vis Sci,2014,91(1):3-12.
[16] TAGLIAFERRI A,LOVE TE,SZCZOTKA-FLYNN LB.Risk factors for contact lens-induced papillary conjunctivitis associated with silicone hydrogel contact lens wear[J].Eye Contact Lens,2014,40(3):117-22.
[17] TSUCHIYA M,ASANO M,ODA M.Basic aspects of microcirculation[C]//Organizing Committee.eds.Proceedings of the Tokyo international symposium on microcirculation.Amsterdam,Oxford,Princeton:Elsevier Science Publisher,1981:85.
[18] 李娟,丁小艳,王亚虹,叶鳞泓,叶蕾,姜楠,等.PM2.5对小鼠泪膜功能和角膜上皮组织结构的影响[J].眼科新进展,2017,37(3):201-204
LI J,DING XY,WANG YH,YE LH,YE L,JIANG N,et al.Effects of PM2.5 on tear film function and corneal epithelial structure in mice[J].Rec Adv Ophthalmol,2017,37(3):201-204
[19] 容蓉,石颖颖,邵毅.视网膜功能影像检查技术在视网膜疾病中的临床应用[J].眼科新进展,2017,37(4):388-391.
RONG R,SHI YY,SHAO Y,Application of retinal functional imager in retinal diseases[J].Rec Adv Ophthalmol,2017,37(4):388-391.

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备注/Memo

备注/Memo:
国家自然科学基金资助(编号:81660158、81160118、81460092、81400372);江西省远航工程(编号:2014022);江西省自然科学基金重大项目(编号:2016ACB21017);江西省青年科学基金(编号:20151BAB215016);江西省科技支撑计划项目(编号:20151BBG70223);江西省卫计委面上项目(编号:20175116)
更新日期/Last Update: 2017-10-24