[1]孙园园,郭大东,毕宏生.MicroRNA在葡萄膜炎发病过程中的调控作用研究进展[J].眼科新进展,2016,36(11):1082-1085.[doi:10.13389/j.cnki.rao.2016.0289]
　SUN Yuan-Yuan,GUO Da-Dong,BI Hong-Sheng.Recent advances in regulatory effects of microRNA in pathogenesis of uveitis[J].Recent Advances in Ophthalmology,2016,36(11):1082-1085.[doi:10.13389/j.cnki.rao.2016.0289]
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MicroRNA在葡萄膜炎发病过程中的调控作用研究进展
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年11期
页码:
1082-1085
栏目:
文献综述
出版日期:
2016-11-05

文章信息/Info

Title:
Recent advances in regulatory effects of microRNA in pathogenesis of uveitis
作者:
孙园园; 郭大东; 毕宏生
250014　山东省济南市，山东中医药大学（孙园园）；250002　山东省济南市，山东中医药大学眼科研究所（郭大东，毕宏生）
Author(s):
SUN Yuan-Yuan ; GUO Da-Dong ;  BI Hong-Sheng
Shandong University of Traditional Chinese Medicine ( SUN Yuan-Yuan ) , Jinan 250014, Shandong Province . China ; Eye Innitute , Shandong University of Traditional Chinese Medicine ( GUO Da-Dong, BI Hong-Sheng ) , Jinan 250002 , Shandong Province . China
关键词:
MiRNA; 葡萄膜炎; 调控作用
Keywords:
microRNA ;  uveitis ;  regulatory effect
分类号:
Ｒ７７４.１
DOI:
10.13389/j.cnki.rao.2016.0289
文献标志码:
A
摘要:
微小ＲＮＡ（ｍｉｃｒｏＲＮＡ，ｍｉＲＮＡ）是生物体内源性的、约１９～２４个核苷酸构成的非编码单链ＲＮＡ分子。ｍｉＲＮＡ可以与靶标ｍＲＮＡ基因的３’端非编码区域（３’ＵＴＲ）互补结合，从而在转录后水平负调控靶基因的表达。ｍｉＲＮＡ通过降解靶基因或者抑制转录后的翻译水平，进而影响细胞的分化、增殖和凋亡，并在生物生长发育和疾病发生发展过程中发挥重要的调节作用。近年来研究表明，ｍｉＲＮＡ在葡萄膜炎的发生发展进程中同样发挥重要的调控作用。本文就ｍｉＲＮＡ在葡萄膜炎发生发展过程中的调控作用作一综述，为深入研究葡萄膜炎的发病机理提供新思路。
Abstract:
MicroRNA ( nuRNA) is uncoded by a single-stranded RNA molecule that is endogenous,consisting of about 22 nucleotides. miRNA can bind t0 3 ’ untranslated region ( 3 ’ UTR) of target mRNA gene complementary , resulting in a negative regulation of target genes after transcriptional level. miRNA can degrade target mRNA or inhibit the translational level of their target mRNAs . which in turn affects cell differentiation. proliferation and apoptosis, and thus playing an important role in the regulation in the occurrence of diseases and the development of the organism. Recent studies have shown that miRNA also plays an important regulatory role in the development of uveitis. This article reviews the regulatory effect of microRNA in the development of uveitis, providing a new insight in the pathogenesis of uveitis.

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备注/Memo

备注/Memo:
高等学校博士学科点专项科研基金（ 编号：２０１３３７３１１１０００４）；山东中医药科技发展计划（编号：２０１５-１４５）
更新日期/Last Update: 2016-11-29